{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T05:16:05Z","timestamp":1783055765221,"version":"3.54.6"},"reference-count":128,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:p>Modern nutrition research has evolved from early discoveries of essential vitamins to exploring the complex interactions between a much larger range of food-derived compounds (the foodome). The microbiome is a key link between diet and health outcomes through multiple gut-host axes. However, the field lacks a unifying framework to demystify its inherent complexities. This review outlines mechanistic evidence that the 5\u2019-AMP-activated protein kinase (AMPK) is a potential mediator of host-microbe relationships and helps move towards the concept of a gut-AMPK axis. Further, it suggests that a plausible function of a \u201chealthy\u201d gut microbiome is to increase the bioavailability of metabolites capable of modulating AMPK. These insights can facilitate larger efforts to define what constitutes a functional gut microbiome, understand the health effects of the broader foodome, and support organismal resilience and healthy aging.<\/jats:p>","DOI":"10.3389\/fphys.2026.1861013","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T04:22:42Z","timestamp":1783052562000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Toward a gut-AMPK axis: the microbiome and AMPK signaling in nutrition and healthy aging"],"prefix":"10.3389","volume":"17","author":[{"given":"Erik","family":"Dassoff","sequence":"first","affiliation":[{"name":"Independent Researcher","place":["Tacoma, WA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hashim","family":"Islam","sequence":"additional","affiliation":[{"name":"School of Health and Exercise Science, The University of British Columbia Okanagan","place":["Kelowna, BC, Canada"]},{"name":"Center for Chronic Disease Prevention and Management, The University of British Columbia Okanagan","place":["Kelowna, BC, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Allen","sequence":"additional","affiliation":[{"name":"Department of Health and Kinesiology, University of Illinois at Urbana-Champaign","place":["Urbana, IL, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1016\/J.CHOM.2022.04.016","article-title":"Rethinking healthy eating in light of the gut microbiome","volume":"30","author":"Armet","year":"2022","journal-title":"Cell Host Microbe"},{"key":"B2","doi-asserted-by":"publisher","first-page":"4358","DOI":"10.1096\/FJ.11-190587","article-title":"AMP-activated protein kinase enhances the phagocytic ability of macrophages and neutrophils","volume":"25","author":"Bae","year":"2011","journal-title":"FASEB J."},{"key":"B3","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.chom.2017.07.006","article-title":"The gut microbiota, food science, and human nutrition: a timely marriage","volume":"22","author":"Barratt","year":"2017","journal-title":"Cell Host Microbe"},{"key":"B4","doi-asserted-by":"publisher","first-page":"839","DOI":"10.3945\/AN.117.016568","article-title":"Cardiovascular and antiobesity effects of resveratrol mediated through the gut microbiota","volume":"8","author":"Bird","year":"2017","journal-title":"Adv. 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