{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:54:32Z","timestamp":1791262472351,"version":"4.1.0"},"reference-count":45,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012906","name":"Department of Education of Shandong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012906","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Gouty arthritis is caused by the deposition of monosodium urate monohydrate (MSUM) crystals in joints. Current drug therapies are often limited by side effects, and invasive procedures carry associated risks. This study aims to provide a theoretical basis for local physical treatment of gout by identifying specific mid-infrared frequencies for irradiating MSUM crystals via photon-phonon resonant absorption.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The vibrational spectra of crystalline MSUM were simulated using first-principles density functional theory. The infrared and Raman peaks were mapped to their corresponding vibrational modes, and relative infrared activities were analyzed. The infrared spectrum of an anhydrous monosodium urate model (anhydrous MSU) was also calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Analysis of the vibrational spectra revealed infrared characteristic peaks at 1637 and 1696 cm\n                      <jats:sup>-<\/jats:sup>\n                      \u00b9 for MSUM and at 1627 and 1705 cm\n                      <jats:sup>-<\/jats:sup>\n                      \u00b9 for anhydrous MSU. This finding provides the theoretical foundation for scanning 1627\u20131705 cm\n                      <jats:sup>-<\/jats:sup>\n                      \u00b9 (48.78\u201351.11 THz) to resonantly excite the crystals.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>The irradiation of MSUM crystals with a mid-infrared laser near 50 THz is proposed for initial frequency-scanning experiments. A optical fiber placed near deeper deposits could shorten the distance traveled through tissue. However, experimental validation is required to determine suitable irradiation conditions and assess safety and efficacy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fphys.2026.1868909","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:26:38Z","timestamp":1791260798000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Targeted physical therapy for gouty arthritis: a first-principles frequency-screening study"],"prefix":"10.3389","volume":"17","author":[{"given":"Yuqi","family":"Xia","sequence":"first","affiliation":[{"name":"Shandong Provincial Key Laboratory of Nuclear Science, Nuclear Energy Technology and Comprehensive Utilization, Weihai Frontier Innovation Institute of Nuclear Technology, Shandong University","place":["Weihai, China"]},{"name":"School of Space Science and Technology, Shandong University","place":["Weihai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Guan","sequence":"additional","affiliation":[{"name":"School of Space Science and Technology, Shandong University","place":["Weihai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peilin","family":"Li","sequence":"additional","affiliation":[{"name":"SDU-ANU Joint Science College, Shandong University","place":["Weihai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yitong","family":"Wang","sequence":"additional","affiliation":[{"name":"SDU-ANU Joint Science College, Shandong University","place":["Weihai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yawen","family":"Li","sequence":"additional","affiliation":[{"name":"School of Space Science and Technology, Shandong University","place":["Weihai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyan","family":"Xie","sequence":"additional","affiliation":[{"name":"SDU-ANU Joint Science College, Shandong University","place":["Weihai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Space Science and Technology, Shandong University","place":["Weihai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Li","sequence":"additional","affiliation":[{"name":"School of Space Science and Technology, Shandong University","place":["Weihai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shandong Provincial Key Laboratory of Nuclear Science, Nuclear Energy Technology and Comprehensive Utilization, Weihai Frontier Innovation Institute of Nuclear Technology, Shandong University","place":["Weihai, China"]},{"name":"School of Space Science and Technology, Shandong University","place":["Weihai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,10,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/0895-4356(88)90127-8","article-title":"Gout and coronary heart disease: The Framingham study","volume":"41","author":"Abbott","year":"1988","journal-title":"J. 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