{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T05:03:10Z","timestamp":1784782990514,"version":"3.55.0"},"reference-count":58,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["4R00DK138271"],"award-info":[{"award-number":["4R00DK138271"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:p>\n                    Accumulating evidence establishes intracellular Ca\n                    <jats:sup>2+<\/jats:sup>\n                    signaling as a central regulator of lymphatic endothelial function, with transient receptor potential (TRP) channels emerging as key molecular regulators that may translate mechanical, chemical, and inflammatory cues into lymphatic vascular responses. TRP channel\u2013mediated signaling influences multiple aspects of lymphatic biology, including vessel development, endothelial barrier regulation, contractility, and lymph transport. Dysregulation of these pathways contributes to lymphatic dysfunction in inflammatory, metabolic, and cardiovascular diseases. A deeper mechanistic understanding of TRP channel signaling in the lymphatic vasculature may reveal novel therapeutic targets for lymphatic disorders and related pathologies. This review summarizes current evidence on the roles of TRP channels in the lymphatic vascular system.\n                  <\/jats:p>","DOI":"10.3389\/fphys.2026.1883288","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T04:28:09Z","timestamp":1784780889000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Role of TRP channels in lymphatic function"],"prefix":"10.3389","volume":"17","author":[{"given":"Xinyu","family":"Cao","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Toxicology & Neuroscience, Louisiana State University Health Sciences-Shreveport","place":["Shreveport, LA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen-Lin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Toxicology & Neuroscience, Louisiana State University Health Sciences-Shreveport","place":["Shreveport, LA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1161\/CIRCRESAHA.108.192765","article-title":"Ciliary polycystin-2 is a mechanosensitive calcium channel involved in nitric oxide signaling cascades","volume":"104","author":"AbouAlaiwi","year":"2009","journal-title":"Circ. 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