{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:52:18Z","timestamp":1791363138789,"version":"4.3.1"},"reference-count":43,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Adolescents with overweight or obesity commonly exhibit reduced cardiorespiratory fitness (CRF), which is closely associated with cardiometabolic risk and premature mortality in adulthood. High-intensity interval training (HIIT) has been proposed as a time-efficient exercise strategy; however, quantitative evidence regarding the dose of HIIT in adolescents with overweight or obesity remains limited. Objective: This study aimed to evaluate the effects of HIIT on CRF in adolescents with overweight or obesity and to explore the nonlinear association between weekly HIIT dose and improvements in CRF using dose\u2013response meta-analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      PubMed, Embase, Web of Science, Scopus, and CNKI were searched from database inception to March 2026. Eligible studies were randomized controlled trials involving adolescents aged 10\u201318 years with overweight or obesity. Interventions consisted of structured HIIT or sprint interval training, and comparators included usual care, health education, or no additional structured exercise. The outcomes were VO\n                      <jats:sub>2<\/jats:sub>\n                      max\/VO\n                      <jats:sub>2<\/jats:sub>\n                      peak measured in the laboratory, or equivalent CRF indices estimated using standardized field tests. Two reviewers independently performed study screening, data extraction, and risk-of-bias assessment using the RoB 2 tool. Random-effects meta-analysis was used to Hedges\u2019 g, and restricted cubic splines were further applied to examine the nonlinear relationship between weekly HIIT dose (MET-min\/week) and CRF improvement.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sixteen randomized controlled trials, including 19 effect sizes were included. Compared with control conditions, HIIT significantly improved CRF (Hedges\u2019 g, 1.13, 95% CrI: 0.80\u20131.50). Exploratory subgroup analyses suggested more stable positive effects in studies using three sessions per week, a work-to-recovery ratio of approximately 1:1, and VO\n                      <jats:sub>2<\/jats:sub>\n                      max\/VO\n                      <jats:sub>2<\/jats:sub>\n                      peak as the CRF outcome. Exploratory dose\u2013response analysis suggested an inverted U-shaped association between weekly HIIT dose and CRF improvement, with the largest predicted effect observed at approximately 360 MET-min\/week. However, this estimate should be interpreted cautiously because of the limited number of trials, between-study heterogeneity, and assumptions involved in MET-min\/week conversion.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HIIT may be an effective strategy for improving CRF in adolescents with overweight or obesity. Its benefits appear to depend not only on the use of HIIT per se, but also on training frequency, work\u2013recovery structure, and weekly dose. Current evidence suggests a possible nonlinear association between weekly HIIT dose and CRF improvement; however, this finding is hypothesis-generating rather than definitive and should be verified in larger trials with standardized HIIT prescription reporting, transparent dose coding, and longer follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Systematic review registrations<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link>https:\/\/www.crd.york.ac.uk\/PROSPERO<\/jats:ext-link>\n                      , identifier CRD420261392042.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fphys.2026.1885059","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:37:54Z","timestamp":1787031474000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of high-intensity interval training on cardiorespiratory fitness in adolescents with overweight or obesity: a systematic review and dose\u2013response meta-analysis"],"prefix":"10.3389","volume":"17","author":[{"given":"Jinchen","family":"Pan","sequence":"first","affiliation":[{"name":"China Basketball College, Beijing Sport University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xusong","family":"Dong","sequence":"additional","affiliation":[{"name":"Strength And Conditioning Training College, Beijing Sports University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiqi","family":"Cheng","sequence":"additional","affiliation":[{"name":"School of Athletic Performance, Shanghai University of Sport","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianmei","family":"Cui","sequence":"additional","affiliation":[{"name":"College of Physical Education, North University of China","place":["Taiyuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weian","family":"Lin","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Adolescent Health Assessment and Exercise Intervention of the Ministry of Education, East China Normal University","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zheng","sequence":"additional","affiliation":[{"name":"China Basketball College, Beijing Sport University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1575","DOI":"10.1249\/MSS.0b013e31821ece12","article-title":"2011 compendium of physical activities: a second update of codes and MET values","volume":"43","author":"Ainsworth","year":"2011","journal-title":"Med. 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