{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T05:07:50Z","timestamp":1789103270180,"version":"build-2803163510"},"reference-count":63,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To examine whether treadmill exercise improves motor deficits and alters electrophysiological properties of substantia nigra pars reticulata (SNr) PV-lineage neurons in 6-OHDA-lesioned mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Male Pvalb-Cre;Ai14 mice were assigned to Sham, 6-OHDA-lesioned sedentary (PD), and 6-OHDA-lesioned treadmill-exercise (PD+EX) groups. A unilateral 6-OHDA lesion model was established by right striatal injection of 6-OHDA. PD+EX mice underwent treadmill training for 30 min\/day, 5 days\/week for 6 weeks. Motor function was assessed using a 10-min open-field test and three 300-s rotarod trials. Lesion verification, PV Western blotting, and whole-cell patch-clamp recordings of SNr PV-lineage neurons were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Six weeks of treadmill exercise partially improved open-field and rotarod performance in 6-OHDA-lesioned mice. Exercise was also accompanied by partial normalization of several electrophysiological abnormalities in lesioned-side SNr PV-lineage neurons, including input resistance, action potential threshold, evoked firing capacity, F\u2013I gain, and firing adaptation. No significant group differences in regional PV protein abundance were observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Treadmill exercise improved motor performance and was accompanied by partial normalization of the electrophysiological properties of SNr PV-lineage neurons in 6-OHDA-lesioned mice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fphys.2026.1896949","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T04:33:02Z","timestamp":1789101182000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Treadmill exercise improves motor deficits and partially normalizes electrophysiological properties of substantia nigra pars reticulata PV-lineage neurons in 6-OHDA-lesioned mice"],"prefix":"10.3389","volume":"17","author":[{"given":"Wanchun","family":"Xue","sequence":"first","affiliation":[{"name":"College of Sports Science, Jishou University","place":["Jishou, Hunan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Physical Education and Health, Huaihua University","place":["Huaihua, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyu","family":"Chen","sequence":"additional","affiliation":[{"name":"Yulin Normal University","place":["Yulin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.neuro.2017.03.008","article-title":"Single low doses of MPTP decrease tyrosine hydroxylase expression in the absence of overt neuron loss","volume":"60","author":"Alam","year":"2017","journal-title":"Neurotoxicology"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2024.106512","article-title":"Dopamine depletion weakens direct pathway modulation of SNr neurons","volume":"196","author":"Aristieta","year":"2024","journal-title":"Neurobiol. 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