{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T14:34:54Z","timestamp":1787582094111,"version":"build-2736575974"},"reference-count":100,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:p>\n                    Ferroptosis connects disrupted iron handling, phospholipid peroxidation, and insufficient antioxidant defense with cardiovascular injury. Whether exercise can modify ferroptosis-related vulnerability in the heart and vasculature remains an important but incompletely resolved question. This mechanism-centered narrative review evaluates exercise-related evidence across cardiovascular injury contexts and distinguishes direct cardiovascular experiments from supportive marker studies, indirect mechanistic evidence, and human clinical contexts. PubMed was searched through June 2026, with supplementary retrieval from the Web of Science Core Collection and citation tracing. Among available exercise-specific studies, current evidence is most informative in preclinical models, particularly doxorubicin cardiotoxicity, where endurance exercise preconditioning has been linked to reduced iron accumulation, lipid-peroxide injury, mitochondrial damage, and myocardial dysfunction in studies incorporating ferroptosis-sensitive perturbation. Additional evidence from ischemia-reperfusion injury, diabetic cardiomyopathy, cardiac fibrosis, and experimental heart failure suggests that exercise may influence iron handling, the system Xc\n                    <jats:sup>\u2212<\/jats:sup>\n                    \u2013GSH\u2013GPX4 axis, NRF2-related antioxidant regulation, lipid peroxidation, mitochondrial resilience, and inflammatory signaling. However, many studies remain marker-based, and evidence for resistance or combined training in tissue-level cardiovascular ferroptosis is limited. Human exercise studies provide translational context through improvements in vascular, metabolic, inflammatory, and oxidative-stress outcomes, but they do not yet establish ferroptosis modulation in cardiovascular tissue. Future studies require clearer exercise-dose reporting, serial sampling, tissue-level ferroptosis assays, pathway perturbation, clinically relevant models, and validated human biomarkers. Overall, exercise is best interpreted as a promising modifier of ferroptosis-related cardiovascular biology rather than an established ferroptosis-targeted therapy.\n                  <\/jats:p>","DOI":"10.3389\/fphys.2026.1899817","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T13:51:43Z","timestamp":1787579503000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Does exercise modulate ferroptosis-related cardiovascular injury? Mechanistic evidence and translational boundaries"],"prefix":"10.3389","volume":"17","author":[{"given":"Mengzhao","family":"Han","sequence":"first","affiliation":[{"name":"College of Education and Sports Sciences, Yangtze University","place":["Jingzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoran","family":"Huang","sequence":"additional","affiliation":[{"name":"College of Education and Sports Sciences, Yangtze University","place":["Jingzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Physical Education, Shaanxi Normal University","place":["Xi\u2019an, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Sports Education, Tianjin University of Sport","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Ji","sequence":"additional","affiliation":[{"name":"College of Education and Sports Sciences, Yangtze University","place":["Jingzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibing","family":"Yin","sequence":"additional","affiliation":[{"name":"College of Education and Sports Sciences, Yangtze University","place":["Jingzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penglei","family":"Fan","sequence":"additional","affiliation":[{"name":"College of Education and Sports Sciences, Yangtze University","place":["Jingzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinguo","family":"Yuan","sequence":"additional","affiliation":[{"name":"College of Education and Sports Sciences, Yangtze University","place":["Jingzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1016\/j.tem.2021.04.010","article-title":"Ferritinophagy and ferroptosis in the management of metabolic diseases","volume":"32","author":"Ajoolabady","year":"2021","journal-title":"Trends Endocrinol. Metab."},{"key":"B2","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.hipert.2024.07.001","article-title":"Six weeks of a concurrent training therapy improves endothelial function and arterial stiffness in hypertensive adults with minimum non-responders","volume":"41","author":"Alvarez","year":"2024","journal-title":"Hipertensi\u00f3n Y. Riesgo Vasc."},{"key":"B3","doi-asserted-by":"publisher","first-page":"2436","DOI":"10.1056\/NEJMoa0908355","article-title":"Ferric carboxymaltose in patients with heart failure and iron deficiency","volume":"361","author":"Anker","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"B4","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.freeradbiomed.2020.07.026","article-title":"Inhibition of ferroptosis alleviates atherosclerosis through attenuating lipid peroxidation and endothelial dysfunction in mouse aortic endothelial cell","volume":"160","author":"Bai","year":"2020","journal-title":"Free Radical Biol. Med."},{"key":"B5","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1038\/s41586-019-1705-2","article-title":"The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis","volume":"575","author":"Bersuker","year":"2019","journal-title":"Nature"},{"key":"B6","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1038\/nature10777","article-title":"A PGC1-\u03b1-dependent myokine that drives brown-fat-like development of white fat and thermogenesis","volume":"481","author":"Bostr\u00f6m","year":"2012","journal-title":"Nature"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1444","DOI":"10.1161\/CIRCULATIONAHA.122.060257","article-title":"Alox15\/15-HpETE aggravates myocardial ischemia-reperfusion injury by promoting cardiomyocyte ferroptosis","volume":"147","author":"Cai","year":"2023","journal-title":"Circulation"},{"key":"B8","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1016\/j.jaccao.2024.07.016","article-title":"Anthracycline cardiotoxicity in adult cancer patients","volume":"6","author":"Camilli","year":"2024","journal-title":"JACC: Cardio Oncol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1038\/s41392-022-01153-1","article-title":"Exercise training maintains cardiovascular health: Signaling pathways involved and potential therapeutics","volume":"7","author":"Chen","year":"2022","journal-title":"Sig Transduct. Target. Ther."},{"key":"B10","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.bbrc.2019.06.015","article-title":"Role of TLR4\/NADPH oxidase 4 pathway in promoting cell death through autophagy and ferroptosis during heart failure","volume":"516","author":"Chen","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B11","doi-asserted-by":"publisher","first-page":"15515","DOI":"10.1038\/s41598-023-42760-4","article-title":"Oxidative stress induces mitochondrial iron overload and ferroptotic cell death","volume":"13","author":"Chen","year":"2023","journal-title":"Sci. Rep."},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2026.112817","article-title":"Aerobic exercise attenuates cardiac fibrosis in mice via stimulating vitamin D receptor to suppress ferroptosis","volume":"619","author":"Cui","year":"2026","journal-title":"Mol. Cell. Endocrinol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: An iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"B14","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1038\/s41580-024-00703-5","article-title":"The cell biology of ferroptosis","volume":"25","author":"Dixon","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.02523","article-title":"Pharmacological inhibition of cystine\u2013glutamate exchange induces endoplasmic reticulum stress and ferroptosis","volume":"3","author":"Dixon","year":"2014","journal-title":"eLife"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2019.101107","article-title":"NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis","volume":"23","author":"Dodson","year":"2019","journal-title":"Redox Biol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1038\/nchembio.2239","article-title":"ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition","volume":"13","author":"Doll","year":"2017","journal-title":"Nat. Chem. Biol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/S0891-5849(02)00848-1","article-title":"C11-BODIPY581\/591, an oxidation-sensitive fluorescent lipid peroxidation probe: (micro)spectroscopic characterization and validation of methodology","volume":"33","author":"Drummen","year":"2002","journal-title":"Free Radical Biol. Med."},{"key":"B19","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1038\/s41420-025-02372-5","article-title":"Different types of cell death and their interactions in myocardial ischemia\u2013reperfusion injury","volume":"11","author":"Du","year":"2025","journal-title":"Cell. Death Discov."},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.113617","article-title":"CTRP13 attenuates atherosclerosis by inhibiting endothelial cell ferroptosis via activating GCH1","volume":"143","author":"Du","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1161\/CIRCULATIONAHA.116.022924","article-title":"High-intensity interval training in patients with heart failure with reduced ejection fraction","volume":"135","author":"Ellingsen","year":"2017","journal-title":"Circulation"},{"key":"B22","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1038\/s41569-022-00735-4","article-title":"The molecular and metabolic landscape of iron and ferroptosis in cardiovascular disease","volume":"20","author":"Fang","year":"2023","journal-title":"Nat. Rev. Cardiol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"2672","DOI":"10.1073\/pnas.1821022116","article-title":"Ferroptosis as a target for protection against cardiomyopathy","volume":"116","author":"Fang","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B24","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s00395-023-00990-7","article-title":"Deficiency of mitochondrial calcium uniporter abrogates iron overload-induced cardiac dysfunction by reducing ferroptosis","volume":"118","author":"Fefelova","year":"2023","journal-title":"Basic Res. Cardiol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1016\/j.bbrc.2019.10.006","article-title":"Liproxstatin-1 protects the mouse myocardium against ischemia\/reperfusion injury by decreasing VDAC1 levels and restoring GPX4 levels","volume":"520","author":"Feng","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1038\/ncb3064","article-title":"Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice","volume":"16","author":"Friedmann Angeli","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2024.150568","article-title":"Swimming training attenuates doxorubicin induced cardiomyopathy by targeting the mir-17-3p\/KEAP1\/NRF2 axis","volume":"739","author":"Gao","year":"2024","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1038\/cr.2016.95","article-title":"Ferroptosis is an autophagic cell death process","volume":"26","author":"Gao","year":"2016","journal-title":"Cell Res."},{"key":"B29","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/j.molcel.2015.06.011","article-title":"Glutaminolysis and transferrin regulate ferroptosis","volume":"59","author":"Gao","year":"2015","journal-title":"Mol. Cell"},{"key":"B30","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1016\/j.molcel.2018.10.042","article-title":"Role of mitochondria in ferroptosis","volume":"73","author":"Gao","year":"2019","journal-title":"Mol. Cell"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/1293200","article-title":"miR\u2010432\u20105p inhibits the ferroptosis in cardiomyocytes induced by hypoxia\/reoxygenation via activating Nrf2\/SLC7A11 axis by degrading Keap1","volume":"2023","author":"Geng","year":"2023","journal-title":"Anal. Cell. Pathol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1093\/ajcn\/87.1.142","article-title":"Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performance","volume":"87","author":"Gomez-Cabrera","year":"2008","journal-title":"Am. J. Clin. Nutr."},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0045697","article-title":"Impaired transcriptional activity of Nrf2 in age-related myocardial oxidative stress is reversible by moderate exercise training","volume":"7","author":"Gounder","year":"2012","journal-title":"PloS One"},{"key":"B34","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1136\/heartjnl-2022-322030","article-title":"Treating iron deficiency in patients with heart failure: what, why, when, how, where and who","volume":"110","author":"Graham","year":"2024","journal-title":"Heart"},{"key":"B35","doi-asserted-by":"publisher","first-page":"2709","DOI":"10.1161\/01.CIR.98.24.2709","article-title":"Regular physical exercise corrects endothelial dysfunction and improves exercise capacity in patients with chronic heart failure","volume":"98","author":"Hambrecht","year":"1998","journal-title":"Circulation"},{"key":"B36","doi-asserted-by":"publisher","first-page":"24223","DOI":"10.1038\/s41598-024-76243-x","article-title":"Elevated circulating LncRNA NORAD fosters endothelial cell growth and averts ferroptosis by modulating the miR-106a\/CCND1 axis in CAD patients","volume":"14","author":"He","year":"2024","journal-title":"Sci. Rep."},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g1687","article-title":"Better reporting of interventions: template for intervention description and replication (TIDieR) checklist and guide","volume":"348","author":"Hoffmann","year":"2014","journal-title":"BMJ"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.117081","article-title":"Berberine as a novel ACSL4 inhibitor to suppress endothelial ferroptosis and atherosclerosis","volume":"177","author":"Hong","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"B39","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1089\/ars.2023.0492","article-title":"Preconditioning exercise inhibits neuron ferroptosis and ameliorates brain ischemia damage by skeletal muscle\u2013derived exosomes via regulating miR-484\/ACSL4 axis","volume":"41","author":"Huang","year":"2024","journal-title":"Antioxid. Redox Signaling"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.jshs.2025.101032","article-title":"Exerkines: potential regulators of ferroptosis","volume":"14","author":"Jia","year":"2025","journal-title":"J. Sport Health Sci."},{"key":"B41","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1093\/cvr\/cvae270","article-title":"Iron, lipid peroxidation, and ferroptosis play pathogenic roles in atherosclerosis","volume":"121","author":"Jinson","year":"2025","journal-title":"Cardiovasc. Res."},{"key":"B42","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1038\/nchembio.2238","article-title":"Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis","volume":"13","author":"Kagan","year":"2017","journal-title":"Nat. Chem. Biol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"2199","DOI":"10.1016\/S0140-6736(22)02083-9","article-title":"Intravenous ferric derisomaltose in patients with heart failure and iron deficiency in the UK (IRONMAN): an investigator-initiated, prospective, randomised, open-label, blinded-endpoint trial","volume":"400","author":"Kalra","year":"2022","journal-title":"Lancet"},{"key":"B44","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1002\/ejhf.622","article-title":"Serum ferritin and risk for new-onset heart failure and cardiovascular events in the community","volume":"19","author":"Klip","year":"2017","journal-title":"Eur. J. Heart Failure"},{"key":"B45","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1021\/acscentsci.9b01063","article-title":"GTP cyclohydrolase 1\/tetrahydrobiopterin counteract ferroptosis through lipid remodeling","volume":"6","author":"Kraft","year":"2020","journal-title":"ACS Cent. Sci."},{"key":"B46","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1038\/s41586-022-05060-x","article-title":"Spatial multi-omic map of human myocardial infarction","volume":"608","author":"Kuppe","year":"2022","journal-title":"Nature"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2024.1453582","article-title":"8-weeks aerobic exercise ameliorates cognitive deficit and mitigates ferroptosis triggered by iron overload in the prefrontal cortex of APPSwe\/PSEN1dE9 mice through Xc-\/GPx4 pathway","volume":"18","author":"Li","year":"2024","journal-title":"Front. Neurosci."},{"key":"B48","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.freeradbiomed.2024.09.039","article-title":"Ablation of mitophagy receptor FUNDC1 accentuates septic cardiomyopathy through ACSL4-dependent regulation of ferroptosis and mitochondrial integrity","volume":"225","author":"Li","year":"2024","journal-title":"Free Radical Biol. Med."},{"key":"B49","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1038\/s41420-021-00656-0","article-title":"Inhibition of DNMT-1 alleviates ferroptosis through NCOA4 mediated ferritinophagy during diabetes myocardial ischemia\/reperfusion injury","volume":"7","author":"Li","year":"2021","journal-title":"Cell. Death Discov."},{"key":"B50","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.jesf.2024.12.006","article-title":"Acute high-intensity interval exercise is superior to moderate-intensity continuous exercise in enhancing endothelial function and its associated biomarkers in sedentary young individuals: the possible involvement of lactate","volume":"23","author":"Liu","year":"2025","journal-title":"J. Exercise Sci. Fitness"},{"key":"B51","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1159\/000546096","article-title":"Aerobic exercise alleviates doxorubicin-induced cardiotoxicity via inhibition of ferroptosis","volume":"70","author":"Liu","year":"2025","journal-title":"Chemotherapy"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1080\/10641963.2023.2180019","article-title":"Angiotensin II-induced vascular endothelial cells ferroptosis via P53-ALOX12 signal axis","volume":"45","author":"Liu","year":"2023","journal-title":"Clin. Exp. Hypertension"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.116057","article-title":"Ferroptosis in cardiovascular disease","volume":"170","author":"Liu","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"B54","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1038\/nature13148","article-title":"Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy","volume":"509","author":"Mancias","year":"2014","journal-title":"Nature"},{"key":"B55","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1056\/NEJMoa2304968","article-title":"Ferric carboxymaltose in heart failure with iron deficiency","volume":"389","author":"Mentz","year":"2023","journal-title":"N. Engl. J. Med."},{"key":"B56","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1016\/j.jacbts.2022.03.012","article-title":"Iron overload via heme degradation in the endoplasmic reticulum triggers ferroptosis in myocardial ischemia-reperfusion injury","volume":"7","author":"Miyamoto","year":"2022","journal-title":"JACC: Basic to Trans. Sci."},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0295169","article-title":"Comparison of the preconditioning effect of different exercise training modalities on myocardial ischemia-reperfusion injury","volume":"18","author":"Mohammadkhani","year":"2023","journal-title":"PloS One"},{"key":"B58","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.freeradbiomed.2011.10.440","article-title":"Acute exercise stress activates Nrf2\/ARE signaling and promotes antioxidant mechanisms in the myocardium","volume":"52","author":"Muthusamy","year":"2012","journal-title":"Free Radical Biol. Med."},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1016\/j.crmeth.2024.100710","article-title":"A tangible method to assess native ferroptosis suppressor activity","volume":"4","author":"Nakamura","year":"2024","journal-title":"Cell Rep. Methods"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2023.1113270","article-title":"Effect of exercise and antioxidant supplementation on cellular lipid peroxidation in elderly individuals: systematic review and network meta-analysis","volume":"14","author":"Ni","year":"2023","journal-title":"Front. Physiol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1161\/CIRCULATIONAHA.124.068883","article-title":"Redefining iron deficiency in patients with chronic heart failure","volume":"150","author":"Packer","year":"2024","journal-title":"Circulation"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001412","article-title":"2026 heart disease and stroke statistics: A report of US and global data from the American Heart Association","volume":"153","author":"Palaniappan","year":"2026","journal-title":"Circulation"},{"key":"B63","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1038\/s41419-019-2061-8","article-title":"Quantitative proteomic analyses reveal that GPX4 downregulation during myocardial infarction contributes to ferroptosis in cardiomyocytes","volume":"10","author":"Park","year":"2019","journal-title":"Cell Death Dis."},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000410","article-title":"The ARRIVE guidelines 2.0: updated guidelines for reporting animal research","volume":"18","author":"Percie Du Sert","year":"2020","journal-title":"PloS Biol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"1895","DOI":"10.1016\/S0140-6736(20)32339-4","article-title":"Ferric carboxymaltose for iron deficiency at discharge after acute heart failure: a multicentre, double-blind, randomised, controlled trial","volume":"396","author":"Ponikowski","year":"2020","journal-title":"Lancet"},{"key":"B66","doi-asserted-by":"publisher","first-page":"8665","DOI":"10.1073\/pnas.0903485106","article-title":"Antioxidants prevent health-promoting effects of physical exercise in humans","volume":"106","author":"Ristow","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.70580","article-title":"High\u2010intensity interval training attenuates cardiac injury by targeting ferroptosis and endoplasmic reticulum\u2010stress in male rats with heart failure","volume":"13","author":"Sabouri","year":"2025","journal-title":"Physiol. Rep."},{"key":"B68","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.cmet.2008.07.005","article-title":"Glutathione peroxidase 4 senses and translates oxidative stress into 12\/15-lipoxygenase dependent- and AIF-mediated cell death","volume":"8","author":"Seiler","year":"2008","journal-title":"Cell Metab."},{"key":"B69","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1161\/CIRCRESAHA.125.326303","article-title":"Exercise mitigates diabetic cardiomyopathy by suppressing ferroptosis via N -acetyltransferase 10","volume":"137","author":"Shen","year":"2025","journal-title":"Circ. Res."},{"key":"B70","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1038\/nchembio.2079","article-title":"Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis","volume":"12","author":"Shimada","year":"2016","journal-title":"Nat. Chem. Biol."},{"key":"B71","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.1136\/bjsports-2016-096651","article-title":"Consensus on exercise reporting template (CERT): explanation and elaboration statement","volume":"50","author":"Slade","year":"2016","journal-title":"Br. J. Sports Med."},{"key":"B72","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1038\/s41589-020-00734-x","article-title":"Phospholipase iPLA2\u03b2 averts ferroptosis by eliminating a redox lipid death signal","volume":"17","author":"Sun","year":"2021","journal-title":"Nat. Chem. Biol."},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.672391","article-title":"LncAABR07025387.1 enhances myocardial ischemia\/reperfusion injury via miR-205\/ACSL4-mediated ferroptosis","volume":"10","author":"Sun","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.132747","article-title":"Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity","volume":"5","author":"Tadokoro","year":"2020","journal-title":"JCI Insight"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1155\/2024\/5522013","article-title":"Atorvastatin attenuates endothelial cell injury in atherosclerosis through inhibiting ACSL4\u2010mediated ferroptosis","volume":"2024","author":"Tan","year":"2024","journal-title":"Cardiovasc. Ther."},{"key":"B76","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1038\/s41392-025-02216-9","article-title":"STING aggravates ferroptosis-dependent myocardial ischemia-reperfusion injury by targeting GPX4 for autophagic degradation","volume":"10","author":"Wang","year":"2025","journal-title":"Sig Transduct. Target. Ther."},{"key":"B77","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1038\/s41420-022-01183-2","article-title":"Emerging roles of ferroptosis in cardiovascular diseases","volume":"8","author":"Wang","year":"2022","journal-title":"Cell. Death Discov."},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.31083\/j.fbl2907267","article-title":"DHODH alleviates heart failure via the modulation of CoQ-related ferroptotic inhibition","volume":"29","author":"Wang","year":"2024","journal-title":"Front. Biosci. (Landmark Ed)"},{"key":"B79","doi-asserted-by":"publisher","first-page":"2783","DOI":"10.1111\/bph.70352","article-title":"The NADPH oxidase inhibitor Vas2870 prevents myocyte ferroptosis and improves cardiac remodelling and function in doxorubicin\u2010induced cardiomyopathy","volume":"183","author":"Wang","year":"2026","journal-title":"Br. J. Pharmacol."},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103079","article-title":"Endurance exercise preconditioning alleviates ferroptosis induced by doxorubicin-induced cardiotoxicity through mitochondrial superoxide-dependent AMPK\u03b12 activation","volume":"70","author":"Wang","year":"2024","journal-title":"Redox Biol."},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2024.122981","article-title":"P62-autophagic pathway degrades SLC7A11 to regulate ferroptosis in doxorubicin-induced cardiotoxicity","volume":"356","author":"Wang","year":"2024","journal-title":"Life Sci."},{"key":"B82","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1016\/j.cell.2017.09.044","article-title":"PEBP1 wardens ferroptosis by enabling lipoxygenase generation of lipid death signals","volume":"171","author":"Wenzel","year":"2017","journal-title":"Cell"},{"key":"B83","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.atherosclerosis.2018.05.002","article-title":"Aerobic, resistance or combined training: a systematic review and meta-analysis of exercise to reduce cardiovascular risk in adults with metabolic syndrome","volume":"274","author":"Wewege","year":"2018","journal-title":"Atherosclerosis"},{"key":"B84","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.cmet.2017.12.001","article-title":"Extracellular vesicles provide a means for tissue crosstalk during exercise","volume":"27","author":"Whitham","year":"2018","journal-title":"Cell Metab."},{"key":"B85","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1038\/s41419-020-03118-0","article-title":"Excessive phospholipid peroxidation distinguishes ferroptosis from other cell death modes including pyroptosis","volume":"11","author":"Wiernicki","year":"2020","journal-title":"Cell Death Dis."},{"key":"B86","doi-asserted-by":"publisher","first-page":"3086","DOI":"10.1161\/CIRCULATIONAHA.106.675041","article-title":"Superior cardiovascular effect of aerobic interval training versus moderate continuous training in heart failure patients: a randomized study","volume":"115","author":"Wisl\u00f8ff","year":"2007","journal-title":"Circulation"},{"key":"B87","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1038\/s44161-025-00717-y","article-title":"Spatial multiomics of acute myocardial infarction reveals immune cell infiltration through the endocardium","volume":"4","author":"W\u00fcnnemann","year":"2025","journal-title":"Nat. Cardiovasc. Res."},{"key":"B88","doi-asserted-by":"publisher","first-page":"3056","DOI":"10.1038\/s41598-022-06848-7","article-title":"Endothelial cell ferroptosis mediates monocrotaline-induced pulmonary hypertension in rats by modulating NLRP3 inflammasome activation","volume":"12","author":"Xie","year":"2022","journal-title":"Sci. Rep."},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2025.0495","article-title":"Aerobic exercise stabilizes HIF1\u03b1 through P4HA1 to activate Nrf2\/GPX4 inhibiting ferroptosis and attenuating diabetic cardiomyopathy","author":"Xie","year":"2026","journal-title":"Diabetes Metab. J"},{"key":"B90","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1186\/s12967-025-06982-6","article-title":"IGFBP2 plays a key role in aerobic exercise-mediated inhibition of ferroptosis in cardiac ischemia\/reperfusion (I\/R) injury","volume":"23","author":"Yang","year":"2025","journal-title":"J. Transl. Med."},{"key":"B91","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","article-title":"Regulation of ferroptotic cancer cell death by GPX4","volume":"156","author":"Yang","year":"2014","journal-title":"Cell"},{"key":"B92","doi-asserted-by":"publisher","first-page":"219","DOI":"10.17219\/acem\/153599","article-title":"Effects of ferroptosis in myocardial ischemia\/reperfusion model of rat and its association with Sestrin 1","volume":"32","author":"Yang","year":"2022","journal-title":"Adv. Clin. Exp. Med."},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1080\/08941939.2022.2157521","article-title":"Resveratrol attenuates sepsis-induced cardiomyopathy in rats through anti-ferroptosis via the Sirt1\/Nrf2 pathway","volume":"36","author":"Zeng","year":"2023","journal-title":"J. Invest. Surg."},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0317295","article-title":"Dapagliflozin inhibits ferroptosis to improve chronic heart failure by regulating Nrf2\/HO-1\/GPX4 signaling pathway","volume":"20","author":"Zhang","year":"2025","journal-title":"PloS One"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.112605","article-title":"Downregulation of the (pro)renin receptor alleviates ferroptosis-associated cardiac pathological changes via the NCOA 4-mediated ferritinophagy pathway in diabetic cardiomyopathy","volume":"138","author":"Zhang","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2023.1259219","article-title":"Current progress of ferroptosis in cardiovascular diseases","volume":"10","author":"Zhang","year":"2023","journal-title":"Front. Cardiovasc. Med."},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2025.1641635","article-title":"Effects of high-intensity interval training on biomarkers and inflammatory factors in patients with heart failure: a meta-analysis of randomized controlled trials","volume":"12","author":"Zhang","year":"2025","journal-title":"Front. Cardiovasc. Med."},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.124.036555","article-title":"Exercise alleviates cardiovascular diseases by improving mitochondrial homeostasis","volume":"13","author":"Zhang","year":"2024","journal-title":"JAHA"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.3390\/biom14111456","article-title":"Angiotensin II induces vascular endothelial dysfunction by promoting lipid peroxidation-mediated ferroptosis via CD36","volume":"14","author":"Zhou","year":"2024","journal-title":"Biomolecules"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2024.113912","article-title":"Glycyrrhizin attenuates myocardial ischemia reperfusion injury by suppressing inflammation, oxidative stress, and ferroptosis via the HMGB1-TLR4-GPX4 pathway","volume":"435","author":"Zhu","year":"2024","journal-title":"Exp. Cell. Res."}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphys.2026.1899817\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T13:51:45Z","timestamp":1787579505000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphys.2026.1899817\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,24]]},"references-count":100,"alternative-id":["10.3389\/fphys.2026.1899817"],"URL":"https:\/\/doi.org\/10.3389\/fphys.2026.1899817","relation":{},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,24]]},"article-number":"1899817"}}