{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T11:05:55Z","timestamp":1785323155954,"version":"3.55.0"},"reference-count":83,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:p>\n                    Mechanical loading is a defining feature of pregnancy, yet its integration with ion-channel physiology in the myometrium remains incompletely synthesized. This Review examines how uterine stretch, overdistension, oxytocin-associated signaling, extracellular-matrix context, and inflammatory cues are translated into Ca\u00b2\n                    <jats:sup>+<\/jats:sup>\n                    entry, membrane excitability, inflammatory amplification, and contraction timing in the pregnant myometrium. It distinguishes candidate direct mechanosensors from mechanically regulated Ca\u00b2\n                    <jats:sup>+<\/jats:sup>\n                    \/inflammatory coupling pathways and from adjacent excitability regulators, with the strongest human myometrial evidence currently centered on PIEZO1 and setting-limited TRPV4 signaling. It further separates physiologic term parturition from overdistension-associated premature activation and infection\/inflammation-associated preterm birth, which can share downstream modules without being mechanistically interchangeable. Finally, it defines the experimental and translational boundaries that remain to be resolved before channel-centered mechanisms can be interpreted as pharmacologic or clinical intervention strategies.\n                  <\/jats:p>","DOI":"10.3389\/fphys.2026.1901359","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T10:45:26Z","timestamp":1785321926000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Myometrial mechanotransduction and the timing of parturition: ion-channel pathways linking uterine stretch, calcium signaling, and inflammation"],"prefix":"10.3389","volume":"17","author":[{"given":"Xinyu","family":"Han","sequence":"first","affiliation":[{"name":"Wenzhou Hospital of Traditional Chinese Medicine","place":["Wenzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianqiang","family":"Wu","sequence":"additional","affiliation":[{"name":"Wenzhou Hospital of Traditional Chinese Medicine","place":["Wenzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinxin","family":"Hu","sequence":"additional","affiliation":[{"name":"Wenzhou Hospital of Traditional Chinese Medicine","place":["Wenzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.148425","article-title":"Molecular signatures of labor and nonlabor myometrium with parsimonious classification from 2 calcium transporter genes","volume":"6","author":"Ackerman","year":"2021","journal-title":"JCI Insight"},{"key":"B2","doi-asserted-by":"publisher","first-page":"830.e1","DOI":"10.1016\/j.ajog.2015.08.028","article-title":"Uterine overdistention induces preterm labor mediated by inflammation: observations in pregnant women and nonhuman primates","volume":"213","author":"Adams Waldorf","year":"2015","journal-title":"Am. 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