{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T05:08:28Z","timestamp":1789016908603,"version":"build-2803163510"},"reference-count":69,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC114-2320-B-195-003"],"award-info":[{"award-number":["NSTC114-2320-B-195-003"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004861","name":"Mackay Memorial Hospital","doi-asserted-by":"publisher","award":["MMH 113-67, MMH 113-95, MMH 115-030, MMH 114-25"],"award-info":[{"award-number":["MMH 113-67, MMH 113-95, MMH 115-030, MMH 114-25"]}],"id":[{"id":"10.13039\/501100004861","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Clinically widely used acetazolamide is a potent carbonic anhydrase (CA) inhibitor. CA accelerates CO\n                      <jats:sub>2(g)<\/jats:sub>\n                      \u21ccHCO\n                      <jats:sub>3<\/jats:sub>\n                      <jats:sup>-(aq)<\/jats:sup>\n                      bidirectional conversion. CAII, the major functional isoform, primarily resides inside red blood cells (RBCs). Erythrocyte-specific anion transporter or anion exchanger-1 (AE1) determines HCO\n                      <jats:sub>3<\/jats:sub>\n                      <jats:sup>-<\/jats:sup>\n                      permeability across the cell membrane and is considered the rate-limiting factor for intraerythrocytic CO\n                      <jats:sub>2(g)<\/jats:sub>\n                      \/HCO\n                      <jats:sub>3(aq)<\/jats:sub>\n                      conversion facilitated by CAII. This study aimed to use CA-inhibiting acetazolamide to find out whether AE1 could modulate intraerythrocytic CA catalysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>To explore whether erythroid AE1 could modulate the respiratory effects of acetazolamide, we utilized the GPMur mouse model characteristic of higher erythroid AE1 expression for respiratory measurements using whole-body plethysmography (WBP). The effects of acetazolamide and hypercapnia on murine respiration were compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We found that acetazolamide influenced respiration in the same direction as hypercapnia. Increased erythroid AE1 expression (GPMur) counteracted the impacts of hypercapnia\/acetazolamide. Importantly, GPMur\/higher AE1 increased respiratory sensitivity and limited responses to acetazolamide.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Both acetazolamide and hypercapnia drove acidosis. GPMur\/increased AE1 reduced the impacts of acidosis with faster respiratory responses. This supports that AE1 and CAII function in concert to facilitate intraerythrocytic CO\n                      <jats:sub>2<\/jats:sub>\n                      \/HCO\n                      <jats:sub>3<\/jats:sub>\n                      <jats:sup>-<\/jats:sup>\n                      conversion for CO\n                      <jats:sub>2<\/jats:sub>\n                      expiration. Since murine RBC-AE1 could help sensitize respiratory responses to acetazolamide-induced systemic CA inhibition, it warrants future clinical investigation to identify the appropriate dosing of acetazolamide for people with the GP.Mur blood type.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fphys.2026.1908536","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:28:48Z","timestamp":1789014528000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Erythroid anion exchanger-1 (SLC4A1) modulates carbonic anhydrase inhibitor acetazolamide on respiration"],"prefix":"10.3389","volume":"17","author":[{"given":"Cheng-Ta","family":"Lai","sequence":"first","affiliation":[{"name":"Department of Medicine, Mackay Medical University","place":["New Taipei City, Taiwan"]},{"name":"Division of Colon and Rectal Surgery, Department of Surgery, MacKay Memorial Hospital","place":["Taipei, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Heng","family":"Lin","sequence":"additional","affiliation":[{"name":"The Laboratory of Immunogenetics, Department of Medical Research, MacKay Memorial Hospital","place":["New Taipei City, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Hu","sequence":"additional","affiliation":[{"name":"The Laboratory of Immunogenetics, Department of Medical Research, MacKay Memorial Hospital","place":["New Taipei City, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Lin","family":"Lee","sequence":"additional","affiliation":[{"name":"The Laboratory of Immunogenetics, Department of Medical Research, MacKay Memorial Hospital","place":["New Taipei City, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Graduate Institute of Biomedical Sciences, College of Medicine, MacKay Medical University","place":["New Taipei City, Taiwan"]},{"name":"School of Pharmacy, College of Pharmacy, Kaohsiung Medical University","place":["Kaohsiung, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Hsu","sequence":"additional","affiliation":[{"name":"The Laboratory of Immunogenetics, Department of Medical Research, MacKay Memorial Hospital","place":["New Taipei City, Taiwan"]},{"name":"Graduate Institute of Biomedical Sciences, College of Medicine, MacKay Medical University","place":["New Taipei City, Taiwan"]},{"name":"MacKay Junior College of Medicine, Nursing, and Management","place":["New Taipei City, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"4963","DOI":"10.1113\/jphysiol.2013.251181","article-title":"Activity and distribution of intracellular carbonic anhydrase II and their effects on the transport activity of anion exchanger AE1\/SLC4A1","volume":"591","author":"Al-Samir","year":"2013","journal-title":"J. Physiol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000461071","article-title":"Blood group-active surface molecules of the human red blood cell","volume":"58","author":"Anstee","year":"1990","journal-title":"Vox Sang."},{"key":"B3","unstructured":"Acetazolamide"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0082338","article-title":"Energetic and molecular water permeation mechanisms of the human red blood cell urea transporter B","volume":"8","author":"Azouzi","year":"2013","journal-title":"PloS One"},{"key":"B5","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1152\/japplphysiol.00737.2007","article-title":"Unrestrained video-assisted plethysmography: a noninvasive method for assessment of lung mechanical function in small animals","volume":"104","author":"Bates","year":"2008","journal-title":"J. Appl. Physiol. (1985)"},{"key":"B6","doi-asserted-by":"publisher","first-page":"F234","DOI":"10.1152\/ajprenal.1997.273.2.f234","article-title":"Expression of carbonic anhydrase IV in carbonic anhydrase II-deficient mice","volume":"273","author":"Brion","year":"1997","journal-title":"Am. J. Physiol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"4180","DOI":"10.1182\/blood-2002-09-2824","article-title":"A band 3-based macrocomplex of integral and peripheral proteins in the RBC membrane","volume":"101","author":"Bruce","year":"2003","journal-title":"Blood"},{"key":"B8","doi-asserted-by":"publisher","first-page":"2752","DOI":"10.1021\/acs.jproteome.7b00025","article-title":"Quantitative analysis of human red blood cell proteome","volume":"16","author":"Bryk","year":"2017","journal-title":"J. Proteome Res."},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22095029","article-title":"Role of carbonic anhydrase in cerebral ischemia and carbonic anhydrase inhibitors as putative protective agents","volume":"22","author":"Bulli","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1093\/function\/zqae052","article-title":"Increased anion exchanger-1 (band 3) on the red blood cell membrane accelerates scavenging of nitric oxide metabolites and predisposes hypertension risks","volume":"6","author":"Chen","year":"2025","journal-title":"Funct. (Oxf)"},{"key":"B11","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1007\/s10194-012-0426-9","article-title":"Acetazolamide for the prophylaxis of migraine in CADASIL: a preliminary experience","volume":"13","author":"Donnini","year":"2012","journal-title":"J. Headache Pain"},{"key":"B12","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1096\/fj.07-9097com","article-title":"RhAG protein of the Rhesus complex is a CO2 channel in the human red cell membrane","volume":"22","author":"Endeward","year":"2008","journal-title":"FASEB J."},{"key":"B13","doi-asserted-by":"publisher","first-page":"20557","DOI":"10.21203\/rs.3.rs-289404\/v1","article-title":"Ventilatory responses during and following hypercapnic gas challenge are impaired in male but not female endothelial NOS knock-out mice","volume":"11","author":"Getsy","year":"2021","journal-title":"Sci. Rep."},{"key":"B14","doi-asserted-by":"publisher","first-page":"F1447","DOI":"10.1152\/ajprenal.00609.2012","article-title":"Movement of NH(3) through the human urea transporter B: a new gas channel","volume":"304","author":"Geyer","year":"2013","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.26599\/1671-5411.2024.11.005","article-title":"The role of acetazolamide in critical care and emergency medicine","volume":"21","author":"Giamello","year":"2024","journal-title":"J. Geriatr. Cardiol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1164\/ajrccm.156.3.9606031","article-title":"Noninvasive measurement of airway responsiveness in allergic mice using barometric plethysmography","volume":"156","author":"Hamelmann","year":"1997","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"B17","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.tmrv.2019.02.003","article-title":"Molecular detection of glycophorins A and B variant phenotypes and their clinical relevance","volume":"33","author":"Hassan","year":"2019","journal-title":"Transfus. Med. Rev."},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00733","article-title":"Exploring the potential roles of band 3 and aquaporin-1 in blood CO2 transport-inspired by comparative studies of glycophorin B-A-B hybrid protein GP.Mur","volume":"9","author":"Hsu","year":"2018","journal-title":"Front. Physiol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1919","DOI":"10.1182\/blood-2008-12-195180","article-title":"Miltenberger blood group antigen type III (Mi.III) enhances the expression of band 3","volume":"114","author":"Hsu","year":"2009","journal-title":"Blood"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/srep10327","article-title":"Expedited CO2 respiration in people with Miltenberger erythrocyte phenotype GP.Mur","volume":"5","author":"Hsu","year":"2015","journal-title":"Sci. Rep."},{"key":"B21","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1111\/j.1423-0410.2011.01535.x","article-title":"Expression of the Rh\/RhAG complex is reduced in Mi.III erythrocytes","volume":"102","author":"Hsu","year":"2012","journal-title":"Vox Sang."},{"key":"B22","doi-asserted-by":"publisher","first-page":"4256","DOI":"10.1096\/fj.201601282r","article-title":"Adaptable interaction between aquaporin-1 and band 3 reveals a potential role of water channel in blood CO2 transport","volume":"31","author":"Hsu","year":"2017","journal-title":"FASEB J."},{"key":"B23","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1111\/j.1537-2995.2012.03861.x","article-title":"A direct blood polymerase chain reaction approach for the determination of GP.Mur (Mi.III) and other Hil+ Miltenberger glycophorin variants","volume":"53","author":"Hsu","year":"2013","journal-title":"Transfusion"},{"key":"B24","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1016\/j.transci.2013.05.011","article-title":"Assessing the frequencies of GP.Mur (Mi.III) in several Southeast Asian populations by PCR typing","volume":"49","author":"Hsu","year":"2013","journal-title":"Transfus. Apher Sci."},{"key":"B25","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1111\/j.1423-0410.2010.01436.x","article-title":"Miltenberger blood group antigen subtype III (Mi.III) supports Wr(b) expression","volume":"100","author":"Hsu","year":"2011","journal-title":"Vox Sang."},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.740100","article-title":"Comodulation of NO-dependent vasodilation by erythroid band 3 and hemoglobin: a GP.Mur athlete study","volume":"8","author":"Hsu","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"key":"B27","doi-asserted-by":"publisher","first-page":"L825","DOI":"10.1152\/ajplung.00036.2022","article-title":"Effects of greater erythroid Cl(-)\/HCO(3)(-) transporter (band 3) expression on ventilation and gas exchange during exhaustive exercise","volume":"324","author":"Hsu","year":"2023","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1111\/trf.13940","article-title":"Validation of the multiplex ligation-dependent probe amplification assay and its application on the distribution study of the major alleles of 17 blood group systems in Chinese donors from Guangzhou","volume":"57","author":"Ji","year":"2017","journal-title":"Transfusion"},{"key":"B29","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1097\/CRD.0b013e31822b4939","article-title":"Acetazolamide: a forgotten diuretic agent","volume":"19","author":"Kassamali","year":"2011","journal-title":"Cardiol. Rev."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1152\/japplphysiol.01572.2005","article-title":"Mechanisms of action of acetazolamide in the prophylaxis and treatment of acute mountain sickness","volume":"102","author":"Leaf","year":"2007","journal-title":"J. Appl. Physiol. (1985)"},{"key":"B31","doi-asserted-by":"publisher","first-page":"C905","DOI":"10.1152\/ajpcell.00435.2023","article-title":"Functional asymmetry of the urea transporter UT-B in human red blood cells","volume":"326","author":"Leifelt","year":"2024","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"3271","DOI":"10.1113\/JP274726","article-title":"Hypercapnia-induced active expiration increases in sleep and enhances ventilation in unanaesthetized rats","volume":"596","author":"Leirao","year":"2018","journal-title":"J. Physiol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"L301","DOI":"10.1152\/ajplung.1998.274.2.l301","article-title":"Respiratory acidosis in carbonic anhydrase II-deficient mice","volume":"274","author":"Lien","year":"1998","journal-title":"Am. J. Physiol."},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.3791\/51755-v","article-title":"Measuring respiratory function in mice using unrestrained whole-body plethysmography","volume":"12","author":"Lim","year":"2014","journal-title":"J. Vis. Exp."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/s0163-7258(96)00198-2","article-title":"Structure and mechanism of carbonic anhydrase","volume":"74","author":"Lindskog","year":"1997","journal-title":"Pharmacol. Ther."},{"key":"B36","doi-asserted-by":"publisher","first-page":"e551","DOI":"10.1097\/PCC.0000000000000971","article-title":"Acetazolamide therapy for metabolic alkalosis in pediatric intensive care patients","volume":"17","author":"Lopez","year":"2016","journal-title":"Pediatr. Crit. Care Med."},{"key":"B37","first-page":"455","article-title":"Acetazolamide in the treatment of metabolic alkalosis in critically ill patients","volume":"20","author":"Marik","year":"1991","journal-title":"Heart Lung"},{"key":"B38","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1097\/00003246-199801001-00270","article-title":"Single versus multiple doses of acetazolamide for metabolic alkalosis in critically ill medical patients: a randomized, double-blind trial","volume":"27","author":"Mazur","year":"1999","journal-title":"Crit. Care Med."},{"key":"B39","doi-asserted-by":"publisher","first-page":"3772","DOI":"10.1021\/ac020022z","article-title":"Analysis of carbonic anhydrase in human red blood cells using capillary electrophoresis\/ electrospray ionization-mass spectrometry","volume":"74","author":"Moini","year":"2002","journal-title":"Anal. Chem."},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1186\/cc3970","article-title":"Acetazolamide-mediated decrease in strong ion difference accounts for the correction of metabolic alkalosis in critically ill patients","volume":"10","author":"Moviat","year":"2006","journal-title":"Crit. Care"},{"key":"B41","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1056\/nejmoa2203094","article-title":"Acetazolamide in acute decompensated heart failure with volume overload","volume":"387","author":"Mullens","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"B42","doi-asserted-by":"publisher","first-page":"5406","DOI":"10.1073\/pnas.0813231106","article-title":"Relative CO2\/NH3 selectivities of AQP1, AQP4, AQP5, amtB, and rhag","volume":"106","author":"Musa-Aziz","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B43","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1113\/jp289556","article-title":"Mechanism of CO(2) and NH(3) transport through human aquaporin 1: Evidence for parallel CO(2) pathways","volume":"604","author":"Musa-Aziz","year":"2026","journal-title":"J. Physiol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1111\/tme.13136","article-title":"Frequencies of different blood group antigens and phenotypes in Northern Vietnamese donors","volume":"35","author":"Nguyen","year":"2025","journal-title":"Transfus. Med."},{"key":"B45","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1111\/j.1365-3148.2007.00747.x","article-title":"Detection of MNS hybrid molecules in the Thai population using PCR-SSP technique","volume":"17","author":"Palacajornsuk","year":"2007","journal-title":"Transfus. Med."},{"key":"B46","doi-asserted-by":"publisher","first-page":"2597","DOI":"10.1021\/bi00383a028","article-title":"Enzyme kinetics in solvents of increased viscosity. Dynamic aspects of carbonic anhydrase catalysis","volume":"26","author":"Pocker","year":"1987","journal-title":"Biochemistry"},{"key":"B47","doi-asserted-by":"publisher","first-page":"95","DOI":"10.4103\/ajts.ajts_125_21","article-title":"The prevalence of GP Mur and anti-\"Mia\" in a tertiary hospital in Peninsula Malaysia","volume":"24","author":"Prathiba","year":"2002","journal-title":"Malays. J. Pathol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1038\/sj.ki.5002020","article-title":"The role of carbonic anhydrases in renal physiology","volume":"71","author":"Purkerson","year":"2007","journal-title":"Kidney Int."},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2024.1474628","article-title":"On the substrate turnover rate of NBCe1 and AE1 SLC4 transporters: structure-function considerations","volume":"15","author":"Pushkin","year":"2024","journal-title":"Front. Physiol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1007\/s12576-015-0408-1","article-title":"Plethysmography measurements of respiratory function in conscious unrestrained mice","volume":"66","author":"Quindry","year":"2016","journal-title":"J. Physiol. Sci."},{"key":"B51","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1006\/bcmd.2000.0353","article-title":"A membrane metabolon linking carbonic anhydrase with chloride\/bicarbonate anion exchangers","volume":"27","author":"Reithmeier","year":"2001","journal-title":"Blood Cells Mol. Dis."},{"key":"B52","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.1016\/j.bbamem.2016.03.030","article-title":"Band 3, the human red cell chloride\/bicarbonate anion exchanger (AE1, SLC4A1), in a structural context","volume":"1858","author":"Reithmeier","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1111\/vox.70202","article-title":"The distribution of glycophorin GYP(B-A-B) hybrids among blood donors in north-eastern Thailand","volume":"121","author":"Srichankhot","year":"2026","journal-title":"Vox Sang"},{"key":"B54","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1007\/978-3-0348-8446-4_15","article-title":"Respiratory and renal roles of carbonic anhydrase in gas exchange and acid-base regulation","volume":"2000","author":"Swenson","year":"2000","journal-title":"EXS"},{"key":"B55","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1152\/jappl.1993.74.1.230","article-title":"Effects of acute and chronic acetazolamide on resting ventilation and ventilatory responses in men","volume":"74","author":"Swenson","year":"1993","journal-title":"J. Appl. Physiol. (1985)"},{"key":"B56","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1152\/japplphysiol.01407.2006","article-title":"Prevention of acute mountain sickness by acetazolamide: as yet an unfinished story","volume":"102","author":"Swenson","year":"2007","journal-title":"J. Appl. Physiol. (1985)"},{"key":"B57","doi-asserted-by":"publisher","first-page":"511","DOI":"10.2170\/jjphysiol.36.511","article-title":"Difference in the effects of acetazolamide and ammonium chloride acidosis on ventilatory responses to CO2 and hypoxia in humans","volume":"36","author":"Tojima","year":"1986","journal-title":"Jpn. J. Physiol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1016\/j.bpj.2024.11.918","article-title":"Architecture of the human erythrocyte ankyrin-1 complex","volume":"29","author":"Vallese","year":"2022","journal-title":"Nat. Struct. Mol. Biol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1089\/ham.2008.1029","article-title":"Prophylactic low-dose acetazolamide reduces the incidence and severity of acute mountain sickness","volume":"9","author":"van Patot","year":"2008","journal-title":"High Alt. Med. Biol."},{"key":"B60","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/B978-1-4557-0792-8.00006-4","article-title":"Control of ventilation and respiratory muscles","volume-title":"Clinical Respiratory Medicine","author":"Vassilakopoulos","year":"2012"},{"key":"B61","doi-asserted-by":"publisher","first-page":"28430","DOI":"10.3389\/fphys.2017.01108","article-title":"Carbonic anhydrase II binds to the carboxyl terminus of human band 3, the erythrocyte C1-\/HCO3- exchanger","volume":"273","author":"Vince","year":"1998","journal-title":"J. Biol. Chem."},{"key":"B62","doi-asserted-by":"crossref","first-page":"5527","DOI":"10.1021\/bi992564p","article-title":"Identification of the carbonic anhydrase II binding site in the Cl(-)\/HCO(3)(-) anion exchanger AE1","volume":"39","author":"Vince","year":"2000","journal-title":"Biochemistry"},{"key":"B63","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1111\/tme.12265","article-title":"Miltenberger blood group typing by real-time polymerase chain reaction (qPCR) melting curve analysis in Thai population","volume":"25","author":"Vongsakulyanon","year":"2015","journal-title":"Transfus. Med."},{"key":"B64","doi-asserted-by":"publisher","first-page":"1763","DOI":"10.1111\/trf.14641","article-title":"Genotyping analysis of MNS blood group GP(B-A-B) hybrid glycophorins in the Chinese Southern Han population using a high-resolution melting assay","volume":"58","author":"Wei","year":"2018","journal-title":"Transfusion"},{"key":"B65","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1111\/vox.12421","article-title":"The distribution of MNS hybrid glycophorins with Mur antigen expression in Chinese donors including identification of a novel GYP.Bun allele","volume":"111","author":"Wei","year":"2016","journal-title":"Vox Sang."},{"key":"B66","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1111\/tme.12305","article-title":"Mur (MNS 10) screening with a novel loop-mediated isothermal amplification assay in Zhongshan, China","volume":"26","author":"Wei","year":"2016","journal-title":"Transfus. Med."},{"key":"B67","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1152\/japplphysiol.01287.2006","article-title":"Acetazolamide protects against posthypoxic unstable breathing in the C57BL\/6J mouse","volume":"103","author":"Yamauchi","year":"2007","journal-title":"J. Appl. Physiol. (1985)"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11050806","article-title":"Universal detection of Mi(a) antigen and frequencies of glycophorin hybrids among blood donors in Taiwan by human monoclonal antibodies against Mi(a) (MNS7), Mur (MNS10), and MUT (MNS35) antigens","volume":"11","author":"Yang","year":"2021","journal-title":"Diagnostics (Basel)"},{"key":"B69","doi-asserted-by":"publisher","first-page":"36782","DOI":"10.1074\/jbc.m206948200","article-title":"Analysis of double knockout mice lacking aquaporin-1 and urea transporter UT-B. Evidence for UT-B-facilitated water transport in erythrocytes","volume":"277","author":"Yang","year":"2002","journal-title":"J. Biol. Chem."}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphys.2026.1908536\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:28:51Z","timestamp":1789014531000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphys.2026.1908536\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,10]]},"references-count":69,"alternative-id":["10.3389\/fphys.2026.1908536"],"URL":"https:\/\/doi.org\/10.3389\/fphys.2026.1908536","relation":{},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,10]]},"article-number":"1908536"}}