{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T05:08:02Z","timestamp":1789103282570,"version":"build-2803163510"},"reference-count":60,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:p>\n                    Water intake is crucial for livestock performance and welfare. Understanding the mechanisms underlying water homeostasis and stress responses during water shortages is essential for sustainable poultry production. This study examined how water deprivation (WD) affects hepatic genes related to blood pressure (BP) regulation and stress responses in broilers selected for high (HW) and low (LW) water efficiency. The genes analyzed included angiotensinogen (\n                    <jats:italic>AGT<\/jats:italic>\n                    ), renin (\n                    <jats:italic>REN<\/jats:italic>\n                    ), glucocorticoid receptor (\n                    <jats:italic>GR<\/jats:italic>\n                    ), 11\u03b2-hydroxysteroid dehydrogenase-1 (\n                    <jats:italic>11\u03b2-HSD1<\/jats:italic>\n                    ), and brain-derived neurotrophic factor (\n                    <jats:italic>BDNF<\/jats:italic>\n                    ), measured in the liver. Birds from both lines underwent WD for 0, 12, and 24\u00a0h, with liver samples collected on days 38-40. The results showed that\n                    <jats:italic>AGT<\/jats:italic>\n                    and\n                    <jats:italic>REN<\/jats:italic>\n                    levels were higher in male than in female HW birds, indicating gender-specific expression of\n                    <jats:italic>AGT<\/jats:italic>\n                    and\n                    <jats:italic>REN<\/jats:italic>\n                    in the liver. The effects of 12\u00a0h and 24\u00a0h WD were more pronounced in HW than in LW birds, regardless of sex, implying a higher responsiveness of HW birds to WD stress. In both HW and LW, females exhibited higher\n                    <jats:italic>GR<\/jats:italic>\n                    and\n                    <jats:italic>11\u03b2-HSD1<\/jats:italic>\n                    levels than males. WD elevated\n                    <jats:italic>GR<\/jats:italic>\n                    and\n                    <jats:italic>11\u03b2-HSD1<\/jats:italic>\n                    expression in HW males but not in HW females, indicating a gender-specific stress response in the liver of HW birds. Conversely, LW females showed decreased\n                    <jats:italic>GR<\/jats:italic>\n                    levels after WD, and\n                    <jats:italic>11\u03b2-HSD1<\/jats:italic>\n                    was reduced after 24\u00a0h of WD in both sexes, suggesting a destructive stress response in LW birds.\n                    <jats:italic>BDNF<\/jats:italic>\n                    expression was three times higher in HW males than in HW females, with no significant gender difference in LW, suggesting a possible functional role for BDNF in the WD stress response and liver welfare. WD caused a time-dependent reduction in\n                    <jats:italic>BDNF<\/jats:italic>\n                    in both lines, indicating that water efficiency does not influence\n                    <jats:italic>BDNF<\/jats:italic>\n                    expression by gender. Overall, HW birds may demonstrate greater resilience in water homeostasis and BP regulation compared to LW birds. Hepatic\n                    <jats:italic>BDNF<\/jats:italic>\n                    expression levels in broilers may serve as a potential diagnostic marker of poultry health.\n                  <\/jats:p>","DOI":"10.3389\/fphys.2026.1919762","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T04:34:45Z","timestamp":1789101285000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of water-deprivation stress on the expression of hepatic genes involved in blood pressure and stress response in chickens"],"prefix":"10.3389","volume":"17","author":[{"given":"Seong W.","family":"Kang","sequence":"first","affiliation":[{"name":"Department of Poultry Science, Center of Excellence for Poultry Science, University of Arkansas","place":["Fayetteville, AR, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chloe H.","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Arkansas","place":["Fayetteville, AR, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosie H.","family":"Whittle","sequence":"additional","affiliation":[{"name":"Department of Poultry Science, Center of Excellence for Poultry Science, University of Arkansas","place":["Fayetteville, AR, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Perretti","sequence":"additional","affiliation":[{"name":"Department of Poultry Science, Center of Excellence for Poultry Science, University of Arkansas","place":["Fayetteville, AR, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaelen M.","family":"Cherry","sequence":"additional","affiliation":[{"name":"Department of Poultry Science, Center of Excellence for Poultry Science, University of Arkansas","place":["Fayetteville, AR, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maricela A.","family":"Maqueda","sequence":"additional","affiliation":[{"name":"Department of Poultry Science, Center of Excellence for Poultry Science, University of Arkansas","place":["Fayetteville, AR, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara K.","family":"Orlowski-Workman","sequence":"additional","affiliation":[{"name":"Department of Poultry Science, Center of Excellence for Poultry Science, University of Arkansas","place":["Fayetteville, AR, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young M.","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Poultry Science, Center of Excellence for Poultry Science, University of Arkansas","place":["Fayetteville, AR, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawna L.","family":"Weimer","sequence":"additional","affiliation":[{"name":"Department of Poultry Science, Center of Excellence for Poultry Science, University of Arkansas","place":["Fayetteville, AR, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/S0039-128x(99)00076-8","article-title":"Repeated immobilization stress increases total cytosolic glucocorticoid receptor in rat liver","volume":"65","author":"Al-Mohaisen","year":"2000","journal-title":"Steroids"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.15972","article-title":"Effect of heat stress on the hypothalamic expression profile of water homeostasis-associated genes in low- and high-water efficient chicken lines","volume":"12","author":"Aloui","year":"2024","journal-title":"Physiol. 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