{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:01:08Z","timestamp":1790830868803,"version":"4.1.0"},"reference-count":66,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Fibromyalgia (FM) and irritable bowel syndrome (IBS) frequently co-occur, sharing pathophysiological mechanisms such as central sensitization and gut-brain axis dysregulation. Given that exercise is a first-line non-pharmacological intervention for FM, detailed baseline characterization may inform future exercise-based research. This study aimed to describe the physical, functional, symptomatic, and quality-of-life profile of women with FM+IBS comorbidity in relation to FM severity, assessed continuously and, secondarily, categorically using the Revised Fibromyalgia Impact Questionnaire (FIQR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross-sectional observational study, conducted at IRCCS \u201cSaverio de Bellis\u201d (Castellana Grotte, Bari, Italy), enrolled 33 women (mean age 47.7 \u00b1 8.6 years) diagnosed with FM (2016 ACR criteria) and IBS (Rome IV criteria). Participants were stratified into three groups by FIQR score: Remission\/Mild (n=7), Moderate (n=13), and High Severity (n=13). FIQR total score was analyzed as a continuous exposure using Spearman correlations with bootstrapped 95% CIs as the primary analysis; the three-group stratification was retained as a secondary, exploratory presentation. Assessments included pain (VAS), tender points, gastrointestinal symptoms (IBS-SSS), kinesiophobia (TSK), sleep quality (PSQI), physical activity (IPAQ), functional fitness tests, and quality of life (SF-36).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Perceived pain showed the strongest association with FIQR severity (Spearman\u2019s rho=0.57, p&amp;lt;0.001), with values nearly doubling in the High Severity versus Remission\/Mild stratum. Physical activity level (IPAQ; exact p=0.021) differed significantly across FIQR strata, with greater inactivity in the Moderate group. Lower-limb functional strength\/endurance, handgrip strength, six-minute walk distance, kinesiophobia, and SF-36 Mental Component Summary were all significantly associated with continuous FIQR (all p&amp;lt;0.05); the Sit-to-Stand difference across categorical strata, significant under standard ANOVA (p=0.048), lost significance under Welch\u2019s ANOVA (p=0.148) and Kruskal-Wallis testing (p=0.072). Gastrointestinal burden remained elevated across all groups, with no clear association with FIQR severity (rho=0.29, p=0.097). Sleep quality and SF-36 scores were markedly impaired regardless of FIQR class.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this exploratory sample, greater FM severity was primarily associated with increased pain and reduced lower-limb functional capacity, while gastrointestinal burden remained consistently elevated across the severity spectrum. These descriptive, hypothesis-generating findings may help guide the design of future, adequately powered studies addressing pain threshold, functional capacity, and gastrointestinal tolerance in exercise management of FM+IBS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fphys.2026.1922718","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:41:26Z","timestamp":1790829686000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical, functional, and quality-of-life characteristics of women with comorbid fibromyalgia and irritable bowel syndrome and their associations with FIQR scores"],"prefix":"10.3389","volume":"17","author":[{"given":"Antonella","family":"Bianco","sequence":"first","affiliation":[{"name":"Laboratory of Movement and Wellness, National Institute of Gastroenterology IRCCS \u201cSaverio de Bellis\u201d","place":["Castellana Grotte, BA, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Verrelli","sequence":"additional","affiliation":[{"name":"Laboratory of Movement and Wellness, National Institute of Gastroenterology IRCCS \u201cSaverio de Bellis\u201d","place":["Castellana Grotte, BA, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Riezzo","sequence":"additional","affiliation":[{"name":"Functional Gastrointestinal Disorders Research Group, National Institute of Gastroenterology IRCCS \u201cSaverio de Bellis\u201d","place":["Castellana Grotte, BA, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetana","family":"Laselva","sequence":"additional","affiliation":[{"name":"Rheumatology Outpatient Clinic, National Institute of Gastroenterology IRCCS \u201cSaverio de Bellis\u201d","place":["Castellana Grotte, BA, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Grasso","sequence":"additional","affiliation":[{"name":"Outpatient Pain Management Unit, National Institute of Gastroenterology IRCCS \u201cSaverio de Bellis\u201d","place":["Castellana Grotte, BA, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Franco","sequence":"additional","affiliation":[{"name":"Laboratory of Movement and Wellness, National Institute of Gastroenterology IRCCS \u201cSaverio de Bellis\u201d","place":["Castellana Grotte, BA, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Prospero","sequence":"additional","affiliation":[{"name":"Functional Gastrointestinal Disorders Research Group, National Institute of Gastroenterology IRCCS \u201cSaverio de Bellis\u201d","place":["Castellana Grotte, BA, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedetta","family":"D\u2019Attoma","sequence":"additional","affiliation":[{"name":"Functional Gastrointestinal Disorders Research Group, National Institute of Gastroenterology IRCCS \u201cSaverio de Bellis\u201d","place":["Castellana Grotte, BA, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"Ignazzi","sequence":"additional","affiliation":[{"name":"Functional Gastrointestinal Disorders Research Group, National Institute of Gastroenterology IRCCS \u201cSaverio de Bellis\u201d","place":["Castellana Grotte, BA, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Noemy","family":"Pastore","sequence":"additional","affiliation":[{"name":"Unit of Data Science, National Institute of Gastroenterology IRCCS \u201cSaverio de Bellis\u201d","place":["Castellana Grotte, BA, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Grazioli","sequence":"additional","affiliation":[{"name":"University of Rome \u201cForo Italico\u201d","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attilio","family":"Parisi","sequence":"additional","affiliation":[{"name":"University of Rome \u201cForo Italico\u201d","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Russo","sequence":"additional","affiliation":[{"name":"Functional Gastrointestinal Disorders Research Group, National Institute of Gastroenterology IRCCS \u201cSaverio de Bellis\u201d","place":["Castellana Grotte, BA, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,10,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/10833196.2022.2157945","article-title":"Evidence-based approaches for the management of fibromyalgia syndrome: a scoping review","volume":"28","author":"Adams","year":"2023","journal-title":"Phys. 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