{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T13:20:10Z","timestamp":1787664010648,"version":"build-2736575974"},"reference-count":120,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:p>Osteosarcopenia is a geriatric syndrome characterized by the overlapping features of osteoporosis and sarcopenia. Its core pathology extends beyond parallel declines in bone and muscle mass. It also involves coordinated disturbances in muscle contractile capacity, skeletal mechanosensitivity, bone marrow cell-lineage commitment, and muscle- and bone-derived secretory signalling. Exercise represents a key non-pharmacological intervention that simultaneously targets skeletal muscle and bone. However, previous studies have mainly focused on changes in systemic bone mineral density, muscle mass, or circulating endocrine factors, whereas the site-specific adaptive relationship between particular muscle groups and adjacent skeletal sites has not been sufficiently integrated. This review aims to address the mechanisms underlying exercise-responsive crosstalk within local muscle\u2013bone units in osteosarcopenia. We focus on the lumbar paraspinal muscle\u2013vertebral body unit and the hip periarticular muscle\u2013proximal femur unit, integrating evidence from imaging studies, animal experiments, exercise interventions, and endocrine mechanisms of muscle\u2013bone communication. Current evidence suggests that exercise promotes adaptive remodeling of local muscle\u2013bone units through site-specific mechanical loading and modulation of the local secretome. This includes both the paraspinal muscle\u2013vertebral body unit and the hip periarticular muscle\u2013proximal femur unit. The concept of exercise-responsive local muscle\u2013bone units provides a translational framework for understanding site-specific degeneration in osteosarcopenia and for developing more precise exercise-based interventions.<\/jats:p>","DOI":"10.3389\/fphys.2026.1923562","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T12:34:01Z","timestamp":1787661241000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Exercise-responsive crosstalk within local muscle-bone units in osteosarcopenia: from mechanotransduction to secretome signalling"],"prefix":"10.3389","volume":"17","author":[{"given":"Zehao","family":"Guan","sequence":"first","affiliation":[{"name":"College of Traditional Chinese Medicine, Changchun University of Traditional Chinese Medicine","place":["Changchun, Jilin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Affiliated Hospital to Changchun University of Traditional Chinese Medicine","place":["Changchun, Jilin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pai","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Andrology, First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongjian","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Affiliated Hospital to Changchun University of Traditional Chinese Medicine","place":["Changchun, Jilin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Affiliated Hospital to Changchun University of Traditional Chinese Medicine","place":["Changchun, Jilin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Medicine, Changchun University of Traditional Chinese Medicine","place":["Changchun, Jilin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yitong","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Medicine, Changchun University of Traditional Chinese Medicine","place":["Changchun, Jilin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,25]]},"reference":[{"key":"B43","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1007\/s00223-014-9863-6","article-title":"The association between hip muscle cross-sectional area, muscle strength, and bone mineral density","volume":"95","author":"Ahedi","year":"2014","journal-title":"Calcif. 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