{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T10:27:52Z","timestamp":1787135272314,"version":"build-2736575974"},"reference-count":143,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:p>Pancreatitis remains a common gastrointestinal disease with no mechanism-specific therapy. Its pathogenesis was long explained by the autodigestion hypothesis: a single linear cascade initiated by premature intra-acinar trypsinogen activation. This trypsin-centric view cannot account for the amplification of inflammation, the switching of cell-death modality, the acute-to-chronic transition, organ failure, or the chronic pancreatitis caused by protein-misfolding genes that act outside the protease system. Here we synthesize evidence from genetically engineered mouse models (GEMMs); their loss- and gain-of-function designs, spanning global and conditional knockouts, knock-ins, and CRISPR\/Cas9 editing, can separate molecular events that are necessary, sufficient, or merely correlated. These models show, for example, that enhanced trypsinogen autoactivation alone is sufficient for spontaneous disease, that NF-\u03baB-driven inflammation can be initiated independently of trypsin, and that loss of autophagy alone disrupts acinar homeostasis. On this basis we reframe pancreatitis as a network pathophysiology with two coupled layers. First, acinar homeostasis is maintained by several semi-independent control modules (digestive-enzyme safety, endoplasmic reticulum protein quality control, the autophagy\u2013lysosome system, the calcium\u2013mitochondria axis, and NF-\u03baB signaling), so that disease can be initiated at any of several independent nodes. Second, the injured acinar cell dies through an interconnected, switchable network of regulated cell death (apoptosis, necroptosis, pyroptosis, ferroptosis, and PANoptosis), sharing nodes such as caspase-8, RIPK3, and GPX4, whose configuration, more than the initiating trigger, determines severity. This framework recasts the heterogeneity of human pancreatitis as different entry points into one network and argues for therapies directed at shared nodes rather than single pathways.<\/jats:p>","DOI":"10.3389\/fphys.2026.1924373","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T10:02:08Z","timestamp":1787133728000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["From single-pathway cascade to network pathophysiology: how genetically engineered mouse models reshaped our understanding of pancreatitis"],"prefix":"10.3389","volume":"17","author":[{"given":"Ting","family":"Yan","sequence":"first","affiliation":[{"name":"Department of General Surgery, Second Affiliated People\u2019s Hospital, Fujian University of Traditional Chinese Medicine","place":["Fuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghua","family":"Lin","sequence":"additional","affiliation":[{"name":"Fujian Provincial Governmental Hospital","place":["Fuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoqun","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Hunan Cancer Hospital\/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingxiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Hunan Cancer Hospital\/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1490","DOI":"10.1172\/JCI29882","article-title":"Pancreas-specific RelA\/P65 truncation increases susceptibility of acini to inflammation-associated cell death following cerulein pancreatitis","volume":"117","author":"Alg\u00fcl","year":"2007","journal-title":"J. Clin. Invest."},{"key":"B2","doi-asserted-by":"publisher","first-page":"E6166","DOI":"10.1073\/pnas.1519384112","article-title":"Basal autophagy maintains pancreatic acinar cell homeostasis and protein synthesis and prevents ER stress","volume":"112","author":"Antonucci","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B3","doi-asserted-by":"publisher","first-page":"e1165","DOI":"10.1038\/cddis.2014.120","article-title":"Expression of human cationic trypsinogen (PRSS1) in murine acinar cells promotes pancreatitis and apoptotic cell death","volume":"5","author":"Athwal","year":"2014","journal-title":"Cell Death Dis."},{"key":"B4","doi-asserted-by":"publisher","first-page":"37","DOI":"10.4291\/wjgp.v9.i2.37","article-title":"Acinar cell injury induced by inadequate unfolded protein response in acute pancreatitis","volume":"9","author":"Barrera","year":"2018","journal-title":"WJGP"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1502","DOI":"10.1172\/JCI30876","article-title":"Constitutive IKK2 activation in acinar cells is sufficient to induce pancreatitis in vivo","volume":"117","author":"Baumann","year":"2007","journal-title":"J. Clin. Invest."},{"key":"B6","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1053\/j.gastro.2017.10.012","article-title":"Mitochondrial dysfunction, through impaired autophagy, leads to endoplasmic reticulum stress, deregulated lipid metabolism, and pancreatitis in animal models","volume":"154","author":"Biczo","year":"2018","journal-title":"Gastroenterology"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1452","DOI":"10.1136\/gutjnl-2024-333406","article-title":"A common CTRB misfolding variant associated with pancreatic cancer risk causes ER stress and inflammation in mice","volume":"74","author":"Bodas","year":"2025","journal-title":"Gut"},{"key":"B8","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1038\/s41419-021-03847-w","article-title":"Necroptosis protects against exacerbation of acute pancreatitis","volume":"12","author":"Boonchan","year":"2021","journal-title":"Cell Death Dis."},{"key":"B9","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1016\/S0140-6736(20)31310-6","article-title":"Acute pancreatitis","volume":"396","author":"Boxhoorn","year":"2020","journal-title":"Lancet"},{"key":"B10","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1097\/MPA.0000000000001793","article-title":"Auxora for the treatment of patients with acute pancreatitis and accompanying systemic inflammatory response syndrome","volume":"50","author":"Bruen","year":"2021","journal-title":"Pancreas"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1995","DOI":"10.1136\/gutjnl-2015-311028","article-title":"Epithelial NEMO\/IKK\u03b3 limits fibrosis and promotes regeneration during pancreatitis","volume":"66","author":"Chan","year":"2017","journal-title":"Gut"},{"key":"B12","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1016\/j.pan.2022.08.011","article-title":"Double deficiency of cathepsin B and L in the mouse pancreas alters trypsin activity without affecting acute pancreatitis severity","volume":"22","author":"Chen","year":"2022","journal-title":"Dig. Dis. Sci."},{"key":"B13","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1053\/gast.2002.31060","article-title":"NF-\u03baB activation in pancreas induces pancreatic and systemic inflammatory response","volume":"122","author":"Chen","year":"2002","journal-title":"Gastroenterology"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3390\/cells9061407","article-title":"Knockout of the mitochondrial calcium uniporter strongly suppresses stimulus-metabolism coupling in pancreatic acinar cells but does not reduce severity of experimental acute pancreatitis","volume":"9","author":"Chvanov","year":"2020","journal-title":"Cells"},{"key":"B15","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1053\/j.gastro.2005.12.031","article-title":"Fatty acid ethyl esters cause pancreatic calcium toxicity via inositol trisphosphate receptors and loss of ATP synthesis","volume":"130","author":"Criddle","year":"2006","journal-title":"Gastroenterology"},{"key":"B16","doi-asserted-by":"publisher","first-page":"2210","DOI":"10.1053\/j.gastro.2011.08.033","article-title":"Intra-acinar trypsinogen activation mediates early stages of pancreatic injury but not inflammation in mice with acute pancreatitis","volume":"141","author":"Dawra","year":"2011","journal-title":"Gastroenterology"},{"key":"B17","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1053\/j.gastro.2022.06.001","article-title":"Rate of autoactivation determines pancreatitis phenotype in trypsinogen mutant mice","volume":"163","author":"Demcs\u00e1k","year":"2022","journal-title":"Gastroenterology"},{"key":"B18","doi-asserted-by":"publisher","first-page":"101361","DOI":"10.1016\/j.jcmgh.2024.05.009","article-title":"Heterozygous Spink1 deficiency promotes trypsin-dependent chronic pancreatitis in mice","volume":"18","author":"Demcs\u00e1k","year":"2024","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1053\/j.gastro.2014.12.003","article-title":"Impaired autophagy induces chronic atrophic pancreatitis in mice via sex- and nutrition-dependent processes","volume":"148","author":"Diakopoulos","year":"2015","journal-title":"Gastroenterology"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: An iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"B21","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1038\/nchembio.2239","article-title":"ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition","volume":"13","author":"Doll","year":"2017","journal-title":"Nat. Chem. Biol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.freeradbiomed.2021.07.009","article-title":"Wedelolactone alleviates acute pancreatitis and associated lung injury via GPX4 mediated suppression of pyroptosis and ferroptosis","volume":"173","author":"Fan","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"B23","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1038\/ng.3249","article-title":"A recombined allele of the lipase gene CEL and its pseudogene CELP confers susceptibility to chronic pancreatitis","volume":"47","author":"Fjeld","year":"2015","journal-title":"Nat. Genet."},{"key":"B24","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1053\/j.gastro.2009.04.003","article-title":"Impaired autolysosome formation correlates with Lamp-2 depletion: Role of apoptosis, autophagy, and necrosis in pancreatitis","volume":"137","author":"Fortunato","year":"2009","journal-title":"Gastroenterology"},{"key":"B25","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1136\/gut.41.3.339","article-title":"Elevated calcium and activation of trypsinogen in rat pancreatic acini","volume":"41","author":"Frick","year":"1997","journal-title":"Gut"},{"key":"B26","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1038\/s41586-019-1770-6","article-title":"Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis","volume":"575","author":"Fritsch","year":"2019","journal-title":"Nature"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1136\/gut.2010.226175","article-title":"Intracellular activation of trypsinogen in transgenic mice induces acute but not chronic pancreatitis","volume":"60","author":"Gaiser","year":"2011","journal-title":"Gut"},{"key":"B28","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1038\/s41418-017-0012-4","article-title":"Molecular mechanisms of cell death: Recommendations of the nomenclature committee on cell death 2018","volume":"25","author":"Galluzzi","year":"2018","journal-title":"Cell Death Differ."},{"key":"B29","doi-asserted-by":"publisher","first-page":"3533","DOI":"10.1111\/bph.15499","article-title":"Acinar cell NLRP3 inflammasome and gasdermin D (GSDMD) activation mediates pyroptosis and systemic inflammation in acute pancreatitis","volume":"178","author":"Gao","year":"2021","journal-title":"Br. J. Pharmacol."},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2025.156767","article-title":"Costunolide: Targeting endothelial cell PANoptosis to mitigate lung injury in acute pancreatitis mice","volume":"142","author":"Ge","year":"2025","journal-title":"Phytomedicine"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.129717","article-title":"Natural single-nucleotide deletion in chymotrypsinogen C gene increases severity of secretagogue-induced pancreatitis in C57BL\/6 mice","volume":"4","author":"Geisz","year":"2019","journal-title":"JCI Insight"},{"key":"B32","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1038\/s41467-018-07347-y","article-title":"A preclinical model of chronic pancreatitis driven by trypsinogen autoactivation","volume":"9","author":"Geisz","year":"2018","journal-title":"Nat. Commun."},{"key":"B33","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1053\/gast.1997.v113.pm9322498","article-title":"Mutations in the cationic trypsinogen gene are associated with recurrent acute and chronic pancreatitis","volume":"113","author":"Gorry","year":"1997","journal-title":"Gastroenterology"},{"key":"B34","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1172\/JCI130172","article-title":"Trypsin activity governs increased susceptibility to pancreatitis in mice expressing human PRSS1R122H","volume":"130","author":"Gui","year":"2019","journal-title":"J. Clin. Invest."},{"key":"B35","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1053\/j.gastro.2012.11.016","article-title":"Nuclear factor-\u03baB in pancreatitis: Jack-of-all-trades, but which one is more important","volume":"144","author":"Gukovsky","year":"2013","journal-title":"Gastroenterology"},{"key":"B36","doi-asserted-by":"publisher","first-page":"G1402","DOI":"10.1152\/ajpgi.1998.275.6.G1402","article-title":"Early NF-\u03baB activation is associated with hormone-induced pancreatitis","volume":"275","author":"Gukovsky","year":"1998","journal-title":"Am. J. Physiol. Gastr. L."},{"key":"B37","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1172\/JCI9411","article-title":"Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis","volume":"106","author":"Halangk","year":"2000","journal-title":"J. Clin. Invest."},{"key":"B38","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1002\/humu.24315","article-title":"Functionally deficient TRPV6 variants contribute to hereditary and familial chronic pancreatitis","volume":"43","author":"Hamada","year":"2022","journal-title":"Hum. Mutat."},{"key":"B39","doi-asserted-by":"publisher","first-page":"C465","DOI":"10.1152\/ajpcell.2001.280.3.C465","article-title":"CCK independently activates intracellular trypsinogen and NF-\u03baB in rat pancreatic acinar cells","volume":"280","author":"Han","year":"2001","journal-title":"Am. J. Physiol. Cell. Ph."},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2025.101620","article-title":"TRPV6-mediated store-operated Ca2+ entry participates in pancreatic acinar cell injury during acute pancreatitis","volume":"19","author":"Han","year":"2025","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1083\/jcb.200712156","article-title":"Involvement of autophagy in trypsinogen activation within the pancreatic acinar cells","volume":"181","author":"Hashimoto","year":"2008","journal-title":"J. Cell Biol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1136\/gutjnl-2018-315994","article-title":"Human CPA1 mutation causes digestive enzyme misfolding and chronic pancreatitis in mice","volume":"68","author":"Hegyi","year":"2019","journal-title":"Gut"},{"key":"B43","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1006\/bbrc.2000.4120","article-title":"Relationship between NF-\u03baB and trypsinogen activation in rat pancreas after supramaximal caerulein stimulation","volume":"280","author":"Hietaranta","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B44","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1053\/j.gastro.2011.03.041","article-title":"TLR9 and the NLRP3 inflammasome link acinar cell death with inflammation in acute pancreatitis","volume":"141","author":"Hoque","year":"2011","journal-title":"Gastroenterology"},{"key":"B45","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1053\/j.gastro.2012.09.059","article-title":"Activation of nuclear factor-\u03baB in acinar cells increases the severity of pancreatitis in mice","volume":"144","author":"Huang","year":"2013","journal-title":"Gastroenterology"},{"key":"B46","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1053\/j.gastro.2019.08.016","article-title":"Transgenic expression of PRSS1R122H sensitizes mice to pancreatitis","volume":"158","author":"Huang","year":"2020","journal-title":"Gastroenterology"},{"key":"B47","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1136\/gutjnl-2022-327601","article-title":"Modelling chronic pancreatitis as a complex genetic disease in mice","volume":"72","author":"Jancs\u00f3","year":"2023","journal-title":"Gut"},{"key":"B48","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1053\/j.gastro.2018.06.041","article-title":"Chymotrypsin reduces the severity of secretagogue-induced pancreatitis in mice","volume":"155","author":"Jancs\u00f3","year":"2018","journal-title":"Gastroenterology"},{"key":"B49","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.pan.2023.02.003","article-title":"Mouse model of PRSS1 p.R122H-related hereditary pancreatitis highlights context-dependent effect of autolysis-site mutation","volume":"23","author":"Jancs\u00f3","year":"2023","journal-title":"Pancreatology"},{"key":"B50","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1053\/j.gastro.2019.11.020","article-title":"Mutation that promotes activation of trypsinogen increases severity of secretagogue-induced pancreatitis in mice","volume":"158","author":"Jancs\u00f3","year":"2020","journal-title":"Gastroenterology"},{"key":"B51","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.pan.2022.01.007","article-title":"Chronic progression of cerulein-induced acute pancreatitis in trypsinogen mutant mice","volume":"22","author":"Jancs\u00f3","year":"2022","journal-title":"Pancreatology"},{"key":"B52","doi-asserted-by":"publisher","first-page":"17488","DOI":"10.1074\/jbc.M109.005520","article-title":"Intracellular trypsin induces pancreatic acinar cell death but not NF-\u03baB activation","volume":"284","author":"Ji","year":"2009","journal-title":"J. Biol. Chem."},{"key":"B53","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1038\/s41586-020-2129-8","article-title":"Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation","volume":"580","author":"Jiao","year":"2020","journal-title":"Nature"},{"key":"B54","doi-asserted-by":"crossref","DOI":"10.1016\/j.chom.2018.05.009","article-title":"Lipid peroxidation drives gasdermin D-mediated pyroptosis in lethal polymicrobial sepsis","volume-title":"Cell Host & Microbe","author":"Kang","year":"2018"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abo6294","article-title":"ZBP1-dependent inflammatory cell death, PANoptosis, and cytokine storm disrupt IFN therapeutic efficacy during coronavirus infection","volume":"7","author":"Karki","year":"2022","journal-title":"Sci. Immunol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1002\/humu.20853","article-title":"Hereditary pancreatitis caused by mutation-induced misfolding of human cationic trypsinogen: A novel disease mechanism","volume":"30","author":"Kereszturi","year":"2009","journal-title":"Hum. Mutat."},{"key":"B57","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.1136\/gut.2006.115725","article-title":"Missense mutations in pancreatic secretory trypsin inhibitor (SPINK1) cause intracellular retention and degradation","volume":"56","author":"Kiraly","year":"2007","journal-title":"Gut"},{"key":"B58","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/BF00432156","article-title":"Acute interstitial pancreatitis in the rat induced by excessive doses of a pancreatic secretagogue","volume":"373","author":"Lampel","year":"1977","journal-title":"Virchows Arch. A. Path. Anat. Histol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1038\/s41586-021-03875-8","article-title":"AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence","volume":"597","author":"Lee","year":"2021","journal-title":"Nature"},{"key":"B60","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1053\/j.gastro.2012.12.043","article-title":"Models of acute and chronic pancreatitis","volume":"144","author":"Lerch","year":"2013","journal-title":"Gastroenterology"},{"key":"B61","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1038\/s41420-025-02451-7","article-title":"Inhibition of Zbp1-PANoptosome-mediated PANoptosis effectively attenuates acute pancreatitis","volume":"11","author":"Li","year":"2025","journal-title":"Cell. Death Discov."},{"key":"B62","doi-asserted-by":"publisher","first-page":"2231","DOI":"10.1172\/JCI64498","article-title":"Loss of acinar cell IKK\u03b1 triggers spontaneous pancreatitis in mice","volume":"123","author":"Li","year":"2013","journal-title":"J. Clin. Invest."},{"key":"B63","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1186\/s12876-024-03481-8","article-title":"Global and regional burden of pancreatitis: Epidemiological trends, risk factors, and projections to 2050 from the global burden of disease study 2021","volume":"24","author":"Li","year":"2024","journal-title":"BMC Gastroenterol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"577","DOI":"10.2119\/molmed.2011.00423","article-title":"Dichotomy between RIP1- and RIP3-mediated necroptosis in tumor necrosis factor-\u03b1-induced shock","volume":"18","author":"Linkermann","year":"2012","journal-title":"Mol. Med."},{"key":"B65","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1038\/s41419-025-07881-w","article-title":"Repurposing BCL2 inhibitors: Venetoclax protects against acinar cell necrosis in acute pancreatitis by promoting apoptosis","volume":"16","author":"Litewka","year":"2025","journal-title":"Cell Death Dis."},{"key":"B66","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/s10495-025-02212-y","article-title":"Suppression of endothelial cell PANoptosis: Qingyi decoction targets the TMAO-HMGB1 pathway to mitigate lung injury in acute pancreatitis rats","volume":"31","author":"Liu","year":"2026","journal-title":"Apoptosis"},{"key":"B67","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/j.jcmgh.2021.09.008","article-title":"Trypsin-mediated sensitization to ferroptosis increases the severity of pancreatitis in mice","volume":"13","author":"Liu","year":"2022","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1038\/s41556-023-01091-2","article-title":"Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis","volume":"25","author":"Liu","year":"2023","journal-title":"Nat. Cell Biol."},{"key":"B69","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1016\/j.bbrc.2020.02.142","article-title":"The circadian clock protects against ferroptosis-induced sterile inflammation","volume":"525","author":"Liu","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B70","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/j.jcmgh.2016.04.002","article-title":"Necroptosis is an important severity determinant and potential therapeutic target in experimental severe pancreatitis","volume":"2","author":"Louhimo","year":"2016","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.110950","article-title":"HDL inhibits pancreatic acinar cell NLRP3 inflammasome activation and protect against acinar cell pyroptosis in acute pancreatitis","volume":"125","author":"Lu","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202500404R","article-title":"Tetrandrine improves severe acute pancreatitis by inhibiting NCOA4 glycosylation\u2010mediated binding to FTH1 and inducing autophagy\u2010dependent ferroptosis","volume":"39","author":"Lu","year":"2025","journal-title":"FASEB J."},{"key":"B73","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1053\/j.gastro.2010.11.038","article-title":"Adaptive unfolded protein response attenuates alcohol-induced pancreatic damage","volume":"140","author":"Lugea","year":"2011","journal-title":"Gastroenterology"},{"key":"B74","doi-asserted-by":"publisher","first-page":"2287","DOI":"10.2147\/JIR.S485804","article-title":"Signaling pathways involved in acute pancreatitis","volume":"18","author":"Luo","year":"2025","journal-title":"JIR"},{"key":"B75","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.jcmgh.2022.03.013","article-title":"The CEL-HYB1 hybrid allele promotes digestive enzyme misfolding and pancreatitis in mice","volume":"14","author":"Mao","year":"2022","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"B76","doi-asserted-by":"publisher","first-page":"3340","DOI":"10.1172\/JCI38674","article-title":"Impaired autophagic flux mediates acinar cell vacuole formation and trypsinogen activation in rodent models of acute pancreatitis","volume":"119","author":"Mareninova","year":"2009","journal-title":"J. Clin. Invest."},{"key":"B77","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1016\/j.jcmgh.2015.07.006","article-title":"Lysosome-associated membrane proteins (LAMP) maintain pancreatic acinar cell homeostasis: LAMP-2\u2013deficient mice develop pancreatitis","volume":"1","author":"Mareninova","year":"2015","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"B78","doi-asserted-by":"publisher","first-page":"3370","DOI":"10.1074\/jbc.M511276200","article-title":"Cell death in pancreatitis: Caspases protect from necrotizing pancreatitis","volume":"281","author":"Mareninova","year":"2006","journal-title":"J. Biol. Chem."},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1172\/JCI146870","article-title":"Dysregulation of mannose-6-phosphate\u2013dependent cholesterol homeostasis in acinar cells mediates pancreatitis","volume":"131","author":"Mareninova","year":"2021","journal-title":"J. Clin. Invest."},{"key":"B80","doi-asserted-by":"publisher","first-page":"1626","DOI":"10.1053\/j.gastro.2020.01.005","article-title":"Variants that affect function of calcium channel TRPV6 are associated with early-onset chronic pancreatitis","volume":"158","author":"Masamune","year":"2020","journal-title":"Gastroenterology"},{"key":"B81","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1007\/s00535-025-02323-y","article-title":"TRPV6-related pancreatitis: Natural history and the impact of the pancreas-specific deletion on pancreatitis in mice","volume":"61","author":"Masamune","year":"2026","journal-title":"J. Gastroenterol."},{"key":"B82","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1136\/gutjnl-2014-308553","article-title":"Mechanism of mitochondrial permeability transition pore induction and damage in the pancreas: Inhibition prevents acute pancreatitis by protecting production of ATP","volume":"65","author":"Mukherjee","year":"2016","journal-title":"Gut"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23073468","article-title":"Structural and biophysical insights into SPINK1 bound to human cationic trypsin","volume":"23","author":"Nagel","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"B84","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1053\/j.gastro.2004.11.052","article-title":"Transgenic expression of pancreatic secretory trypsin inhibitor-I ameliorates secretagogue-induced pancreatitis in mice","volume":"128","author":"Nathan","year":"2005","journal-title":"Gastroenterology"},{"key":"B85","doi-asserted-by":"publisher","first-page":"6357","DOI":"10.1038\/s41598-022-09595-x","article-title":"Misfolding-induced chronic pancreatitis in CPA1 N256K mutant mice is unaffected by global deletion of Ddit3\/Chop","volume":"12","author":"N\u00e9meth","year":"2022","journal-title":"Sci. Rep."},{"key":"B86","doi-asserted-by":"publisher","first-page":"24049","DOI":"10.1074\/jbc.M113.478800","article-title":"Autoactivation of mouse trypsinogens is regulated by chymotrypsin C via cleavage of the autolysis loop","volume":"288","author":"N\u00e9meth","year":"2013","journal-title":"J. Biol. Chem."},{"key":"B87","doi-asserted-by":"publisher","first-page":"11879","DOI":"10.1074\/jbc.M600124200","article-title":"Chymotrypsin C (Caldecrin) stimulates autoactivation of human cationic trypsinogen","volume":"281","author":"Nemoda","year":"2006","journal-title":"J. Biol. Chem."},{"key":"B88","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1053\/j.gastro.2012.09.058","article-title":"Deletion of I\u03baB\u03b1 activates RelA to reduce acute pancreatitis in mice through up-regulation of Spi2A","volume":"144","author":"Neuh\u00f6fer","year":"2013","journal-title":"Gastroenterology"},{"key":"B89","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1038\/cdd.2016.46","article-title":"RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury","volume":"23","author":"Newton","year":"2016","journal-title":"Cell Death Differ."},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1093\/function\/zqad061","article-title":"Neutrophil-specific ORAI1 calcium channel inhibition reduces pancreatitis-associated acute lung injury","volume":"5","author":"Niu","year":"2023","journal-title":"Funct. (Oxf)"},{"key":"B91","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1016\/j.gastro.2005.05.057","article-title":"Autophagic cell death of pancreatic acinar cells in serine protease inhibitor kazal type 3\u2014deficient mice","volume":"129","author":"Ohmuraya","year":"2005","journal-title":"Gastroenterology"},{"key":"B92","doi-asserted-by":"publisher","first-page":"1434","DOI":"10.1016\/j.pan.2021.09.005","article-title":"Loss of function TRPV6 variants are associated with chronic pancreatitis in nonalcoholic early-onset Polish and German patients","volume":"21","author":"Oracz","year":"2021","journal-title":"Pancreatology"},{"key":"B93","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1038\/s41419-023-06063-w","article-title":"Pancreatic acinar cell fate relies on system xC- to prevent ferroptosis during stress","volume":"14","author":"Pan","year":"2023","journal-title":"Cell Death Dis."},{"key":"B94","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.molmed.2023.10.001","article-title":"Therapeutic potential of PANoptosis: Innate sensors, inflammasomes, and RIPKs in PANoptosomes","volume":"30","author":"Pandeya","year":"2024","journal-title":"Trends Mol. Med."},{"key":"B95","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1016\/j.pan.2025.04.020","article-title":"International association of pancreatology revised guidelines on acute pancreatitis 2025: Supported and endorsed by the American Pancreatic Association, European Pancreatic Club, Indian Pancreas Club, and Japan Pancreas Society","volume":"25","author":"P\u00e1rniczky","year":"2025","journal-title":"Pancreatology"},{"key":"B96","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.pan.2022.12.010","article-title":"The 2022 George E Palade Medal Lecture: Toxic Ca2+ signals in acinar, stellate and endogenous immune cells are important drivers of acute pancreatitis","volume":"23","author":"Petersen","year":"2023","journal-title":"Pancreatology"},{"key":"B97","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1136\/gut.50.2.271","article-title":"Novel cationic trypsinogen (PRSS1) N29T and R122C mutations cause autosomal dominant hereditary pancreatitis","volume":"50","author":"Pf\u00fctzer","year":"2002","journal-title":"Gut"},{"key":"B98","doi-asserted-by":"publisher","first-page":"1887","DOI":"10.1093\/hmg\/ddae127","article-title":"An integrated picture of chronic pancreatitis derived by mapping variants in multiple disease genes onto pathogenic pathways","volume":"33","author":"Prasad","year":"2024","journal-title":"Hum. Mol. Genet."},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.3390\/genes12111683","article-title":"Chronic pancreatitis: The true pathogenic culprit within the SPINK1 N34S-containing haplotype is no longer at large","volume":"12","author":"Pu","year":"2021","journal-title":"Genes"},{"key":"B100","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1038\/ng.2007.44","article-title":"Chymotrypsin C (CTRC) variants that diminish activity or secretion are associated with chronic pancreatitis","volume":"40","author":"Rosendahl","year":"2008","journal-title":"Nat. Genet."},{"key":"B101","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1053\/j.gastro.2013.01.041","article-title":"Cerulein-induced chronic pancreatitis does not require intra-acinar activation of trypsinogen in mice","volume":"144","author":"Sah","year":"2013","journal-title":"Gastroenterology"},{"key":"B102","doi-asserted-by":"publisher","first-page":"27551","DOI":"10.1074\/jbc.M113.528174","article-title":"Endoplasmic reticulum stress is chronically activated in chronic pancreatitis","volume":"289","author":"Sah","year":"2014","journal-title":"J. Biol. Chem."},{"key":"B103","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1016\/S0016-5085(97)70108-2","article-title":"Cerulein-induced in vitro activation of trypsinogen in rat pancreatic acini is mediated by cathepsin B","volume":"113","author":"Saluja","year":"1997","journal-title":"Gastroenterology"},{"key":"B104","doi-asserted-by":"publisher","first-page":"1979","DOI":"10.1053\/j.gastro.2019.01.268","article-title":"Early intra-acinar events in pathogenesis of pancreatitis","volume":"156","author":"Saluja","year":"2019","journal-title":"Gastroenterology"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.00238","article-title":"The PANoptosome: A deadly protein complex driving pyroptosis, apoptosis, and necroptosis (PANoptosis)","volume":"10","author":"Samir","year":"2020","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.186516","article-title":"Chronic pancreatitis in T7C140S mice with misfolding cationic trypsinogen mutant","volume":"10","author":"S\u00e1ndor","year":"2025","journal-title":"JCI Insight"},{"key":"B107","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1136\/gutjnl-2012-304331","article-title":"Functional effects of 13 rare PRSS1 variants presumed to cause chronic pancreatitis","volume":"63","author":"Schn\u00far","year":"2014","journal-title":"Gut"},{"key":"B108","doi-asserted-by":"publisher","first-page":"1630","DOI":"10.1186\/1471-230X-6-30","article-title":"Characterisation of a transgenic mouse expressing R122H human cationic trypsinogen","volume":"6","author":"Selig","year":"2006","journal-title":"BMC Gastroenterol."},{"key":"B109","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/j.jcmgh.2016.05.007","article-title":"Necrosis, apoptosis, necroptosis, pyroptosis: It matters how acinar cells die during pancreatitis","volume":"2","author":"Sendler","year":"2016","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"B110","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1053\/j.gastro.2019.09.040","article-title":"NLRP3 inflammasome regulates development of systemic inflammatory response and compensatory anti-inflammatory response syndromes in mice with acute pancreatitis","volume":"158","author":"Sendler","year":"2020","journal-title":"Gastroenterology"},{"key":"B111","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1053\/j.gastro.2017.10.018","article-title":"Cathepsin B-mediated activation of trypsinogen in endocytosing macrophages increases severity of pancreatitis in mice","volume":"154","author":"Sendler","year":"2018","journal-title":"Gastroenterology"},{"key":"B112","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1038\/nature15514","article-title":"Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death","volume":"526","author":"Shi","year":"2015","journal-title":"Nature"},{"key":"B113","doi-asserted-by":"publisher","first-page":"5404","DOI":"10.1074\/jbc.M108073200","article-title":"Hereditary pancreatitis caused by a novel PRSS1 mutation (Arg-122 \u2192 Cys) that alters autoactivation and autodegradation of cationic trypsinogen","volume":"277","author":"Simon","year":"2002","journal-title":"J. Biol. Chem."},{"key":"B114","doi-asserted-by":"publisher","first-page":"4061","DOI":"10.1016\/j.cell.2024.05.034","article-title":"NLRC5 senses NAD+ depletion, forming a PANoptosome and driving PANoptosis and inflammation","volume":"187","author":"Sundaram","year":"2024","journal-title":"Cell"},{"key":"B115","doi-asserted-by":"publisher","first-page":"20701","DOI":"10.1074\/jbc.M112.360065","article-title":"Increased activation of hereditary pancreatitis-associated human cationic trypsinogen mutants in presence of chymotrypsin C","volume":"287","author":"Szab\u00f3","year":"2012","journal-title":"J. Biol. Chem."},{"key":"B116","doi-asserted-by":"publisher","first-page":"11227","DOI":"10.1073\/pnas.0703714104","article-title":"Chymotrypsin C (Caldecrin) promotes degradation of human cationic trypsin: identity with Rinderknecht\u2019s enzyme Y","volume":"104","author":"Szmola","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B117","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1136\/gut.50.5.675","article-title":"The N34S mutation of SPINK1 (PSTI) is associated with a familial pattern of idiopathic chronic pancreatitis but does not cause the disease","volume":"50","author":"Threadgold","year":"2002","journal-title":"Gut"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2025.156926","article-title":"Eriodictyol from Scutellariae barbata alleviates inflammation and necrosis via ZBP1-dependent signaling in acute pancreatitis","volume":"145","author":"Tian","year":"2025","journal-title":"Phytomedicine"},{"key":"B119","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1126\/science.abf0529","article-title":"Copper induces cell death by targeting lipoylated TCA cycle proteins","volume":"375","author":"Tsvetkov","year":"2022","journal-title":"Science"},{"key":"B120","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1126\/science.1209038","article-title":"The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation","volume":"334","author":"Walter","year":"2011","journal-title":"Science"},{"key":"B121","doi-asserted-by":"publisher","first-page":"2051","DOI":"10.1136\/gutjnl-2019-320399","article-title":"Transgenic expression of human PRSS2 exacerbates pancreatitis in mice","volume":"69","author":"Wan","year":"2020","journal-title":"Gut"},{"key":"B122","doi-asserted-by":"publisher","first-page":"1572","DOI":"10.1080\/15548627.2021.1990672","article-title":"Loss of acinar cell VMP1 triggers spontaneous pancreatitis in mice","volume":"18","author":"Wang","year":"2022","journal-title":"Autophagy"},{"key":"B123","doi-asserted-by":"publisher","first-page":"1954","DOI":"10.1080\/15548627.2019.1596486","article-title":"Impaired TFEB-mediated lysosomal biogenesis promotes the development of pancreatitis in mice and is associated with human pancreatitis","volume":"15","author":"Wang","year":"2019","journal-title":"Autophagy"},{"key":"B124","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1053\/j.gastro.2022.03.009","article-title":"Wild-type human PRSS2 and PRSS1R122H cooperatively initiate spontaneous hereditary pancreatitis in transgenic mice","volume":"163","author":"Wang","year":"2022","journal-title":"Gastroenterology"},{"key":"B125","doi-asserted-by":"publisher","first-page":"G473","DOI":"10.1152\/ajpgi.00013.2024","article-title":"A simple and effective genotyping workflow for rapid detection of CRISPR genome editing","volume":"326","author":"Wang","year":"2024","journal-title":"Am. J. Physiol. Gastr. L."},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.107496","article-title":"Cathepsin B aggravates acute pancreatitis by activating the NLRP3 inflammasome and promoting the caspase-1-induced pyroptosis","volume":"94","author":"Wang","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"B127","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1053\/j.gastro.2009.10.048","article-title":"Cathepsin L inactivates human trypsinogen, whereas cathepsin L-deletion reduces the severity of pancreatitis in mice","volume":"138","author":"Wartmann","year":"2010","journal-title":"Gastroenterology"},{"key":"B128","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1053\/j.gastro.2015.04.015","article-title":"Inhibitors of ORAI1 prevent cytosolic calcium-associated injury of human pancreatic acinar cells and acute pancreatitis in 3 mouse models","volume":"149","author":"Wen","year":"2015","journal-title":"Gastroenterology"},{"key":"B129","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1038\/ng1096-141","article-title":"Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene","volume":"14","author":"Whitcomb","year":"1996","journal-title":"Nat. Genet."},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2025.101638","article-title":"Diverse misfolding mutant digestive enzymes cause chronic pancreatitis through common pathways","volume":"20","author":"Wilhelm","year":"2026","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"B131","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1038\/ng.2730","article-title":"Variants in CPA1 are strongly associated with early onset chronic pancreatitis","volume":"45","author":"Witt","year":"2013","journal-title":"Nat. Genet."},{"key":"B132","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/S0016-5085(99)70543-3","article-title":"A signal peptide cleavage site mutation in the cationic trypsinogen gene is strongly associated with chronic pancreatitis","volume":"117","author":"Witt","year":"1999","journal-title":"Gastroenterology"},{"key":"B133","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1038\/76088","article-title":"Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis","volume":"25","author":"Witt","year":"2000","journal-title":"Nat. Genet."},{"key":"B134","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1016\/j.jare.2025.04.006","article-title":"Inflammation-driven biomimetic nano-polyphenol drug delivery system alleviates severe acute pancreatitis by inhibiting macrophage PANoptosis and pancreatic enzymes oversecretion","volume":"79","author":"Wu","year":"2026","journal-title":"J. Adv. Res."},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.110293","article-title":"Endoplasmic reticulum stress promotes caspase-1-dependent acinar cell pyroptosis through the PERK pathway to aggravate acute pancreatitis","volume":"120","author":"Yan","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"B136","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1111\/imcb.12382","article-title":"Serum amyloid A3 is required for caerulein\u2010induced acute pancreatitis through induction of RIP3\u2010dependent necroptosis","volume":"99","author":"Yang","year":"2021","journal-title":"Immunol. Cell Biol."},{"key":"B137","doi-asserted-by":"publisher","first-page":"1733","DOI":"10.1080\/15548627.2022.2152209","article-title":"Extracellular SQSTM1 exacerbates acute pancreatitis by activating autophagy-dependent ferroptosis","volume":"19","author":"Yang","year":"2023","journal-title":"Autophagy"},{"key":"B138","doi-asserted-by":"publisher","first-page":"2747","DOI":"10.3390\/ijerph8072747","article-title":"Genetic risk for alcoholic chronic pancreatitis","volume":"8","author":"Zadrozny Gouv\u00eaa da Costa","year":"2011","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"B139","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.freeradbiomed.2021.02.019","article-title":"PINK1\/PARK2 dependent mitophagy effectively suppresses NLRP3 inflammasome to alleviate acute pancreatitis","volume":"166","author":"Zhang","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.70707","article-title":"Disulfiram protects against multiorgan injuries and cell pyroptosis via inhibiting GSDMD in severe acute pancreatitis mice","volume":"29","author":"Zhao","year":"2025","journal-title":"J. Cell. Mol. Med."},{"key":"B141","doi-asserted-by":"publisher","first-page":"e2918","DOI":"10.1038\/cddis.2017.313","article-title":"RIP3 attenuates the pancreatic damage induced by deletion of ATG7","volume":"8","author":"Zhou","year":"2017","journal-title":"Cell Death Dis."},{"key":"B142","doi-asserted-by":"publisher","first-page":"1340","DOI":"10.1136\/gutjnl-2022-327960","article-title":"Preclinical mouse model of a misfolded PNLIP variant develops chronic pancreatitis","volume":"72","author":"Zhu","year":"2023","journal-title":"Gut"},{"key":"B143","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1002\/humu.24032","article-title":"TRPV6 variants confer susceptibility to chronic pancreatitis in the Chinese population","volume":"41","author":"Zou","year":"2020","journal-title":"Hum. Mutat."}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphys.2026.1924373\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T10:02:10Z","timestamp":1787133730000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphys.2026.1924373\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,19]]},"references-count":143,"alternative-id":["10.3389\/fphys.2026.1924373"],"URL":"https:\/\/doi.org\/10.3389\/fphys.2026.1924373","relation":{},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,19]]},"article-number":"1924373"}}