{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T11:05:42Z","timestamp":1789988742801,"version":"4.0.1"},"reference-count":105,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100019180","name":"HORIZON EUROPE European Research Council","doi-asserted-by":"publisher","award":["101099596"],"award-info":[{"award-number":["101099596"]}],"id":[{"id":"10.13039\/100019180","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:p>\n                    Umbilical vessel closure after birth prevents hemorrhage but limits the time window for large-bore umbilical cannulation required for artificial placenta support. This review synthesizes physiologic triggers, vasoactive pathways, and vessel-wall specializations that drive rapid postnatal occlusion and highlights engineering-relevant targets to prolong functional patency. Umbilical vessel closure is promoted by the transition to extrauterine life (cooling, rising oxygen tension, oxidative stress, loss of placental vasodilator influence), altered hemodynamics after lung aeration, and mechanical stimulation of the cord. At the molecular level, vasoconstriction is driven by redundant mediator networks\u2014most prominently serotonin and thromboxane A\n                    <jats:sub>2<\/jats:sub>\n                    , with supportive contributions from endothelin-1, acetylcholine, bradykinin, catecholamines, and histamine\u2014occurring in the context of limited vasorelaxation capacity. Structurally, the umbilical arteries exhibit a distinctive bilayered tunica media: an outer contractile smooth-muscle-rich layer and an inner proteoglycan-rich layer prone to inward buckling, supported by longitudinal intimal protrusions (Folds of Hoboken) that further promote mechanical occlusion of the lumen. Together, these features form a robust \u201cfail-safe\u201d closure program, although the specific mechanisms governing the intra-abdominal segments remain less understood.\n                  <\/jats:p>","DOI":"10.3389\/fphys.2026.1928360","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T10:43:46Z","timestamp":1789987426000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Enabling artificial placenta cannulation: mechanisms of postnatal umbilical vessel closure and strategies to prolong patency"],"prefix":"10.3389","volume":"17","author":[{"given":"Nils B.","family":"R\u00f6mer","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Paracelsus Medical University","place":["N\u00fcrnberg, Germany"]},{"name":"Faculty of Medicine, University of L\u00fcbeck","place":["L\u00fcbeck, Germany"]},{"name":"Department of Pediatrics, Greifswald University Medical Center","place":["Greifswald, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sjoerd","family":"Haalstra","sequence":"additional","affiliation":[{"name":"Department of Biomechanical Engineering, Engineering Organ Support Technologies, TechMed Centre, University of Twente","place":["Enschede, Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danny J. M.","family":"van Galen","sequence":"additional","affiliation":[{"name":"Department of Biomechanical Engineering, Engineering Organ Support Technologies, TechMed Centre, University of Twente","place":["Enschede, Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daan R. M. G.","family":"Ophelders","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, MosaKids Children\u2019s Hospital, Maastricht University Medical Centre","place":["Maastricht, Netherlands"]},{"name":"GROW Research Institute for Oncology and Reproduction, Maastricht University","place":["Maastricht, Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. Adrienne","family":"Weiss","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Paracelsus Medical University","place":["N\u00fcrnberg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"D\u00e4britz","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Greifswald University Medical Center","place":["Greifswald, Germany"]},{"name":"Department of Pediatrics, Klinikum Ernst von Bergmann","place":["Potsdam, Germany"]},{"name":"Institute for Clinical Research and Systems Medicine, HMU Health and Medical University","place":["Potsdam, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim G. A. 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