{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T05:08:43Z","timestamp":1788930523578,"version":"build-2803163510"},"reference-count":76,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Exercise-mediated extracellular vesicle (EV)-derived non-coding RNAs (ncRNAs) contribute to cardiovascular protection, but a systematic synthesis of the field is lacking, and the evolution of research hotspots and knowledge structure remains unclear. This bibliometric study maps the research landscape, frontier hotspots, and emerging trends, while also interpreting the multi-target synergistic mechanisms underlying exercise-mediated cardioprotection based on published evidence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Publications were retrieved from the Web of Science Core Collection, PubMed, and Scopus from database inception to April 3, 2026. After deduplication and screening, 188 articles were included. VOSviewer, CiteSpace, and the R-based Bibliometrix package were employed for analyses of countries, institutions, journals, highly cited papers, and keywords.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Annual publications grew from 1 in 2013 to 28 in 2025. China (65 publications) and the United States (48 publications) together contributed over 60% of the total. Core journals included Frontiers in Physiology (11 publications), International Journal of Molecular Sciences (9 publications), and Cells (8 publications). Research evolved in three phases: early multi-directional exploration (2015\u20132020), a middle phase converging on EV-centric themes (2021\u20132023), and a recent return to fundamental biology (2023\u20132026). \u201cExtracellular vesicles\u201d ranked first in frequency (48 occurrences), while \u201cphysical activity\u201d had the highest centrality (centrality 0.22). Ten keyword clusters were identified, with \u201caerobic exercise,\u201d \u201canimal model,\u201d and \u201chuman cell\u201d emerging as recent burst keywords. Mechanistically, informed by bibliometric patterns and published preclinical evidence, we propose that exercise may exert anti-apoptotic, antioxidant, anti-inflammatory, and anti-fibrotic effects by engaging a potential synergistic network involving EV-derived ncRNAs, though this framework requires experimental validation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Research in this field is transitioning from mechanistic exploration to clinical translation. China and the United States are the leading contributors, and the intersection of exercise intervention and EVs biology represents the most dynamic research direction. Future efforts should prioritize methodological standardization, large-scale clinical validation, and integration of artificial intelligence approaches, while addressing translational barriers in delivery, manufacturing, regulation, and clinical trial design.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fphys.2026.1945161","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T04:40:59Z","timestamp":1788928859000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Exercise-mediated extracellular vesicle-derived non-coding RNAs and cardiovascular protection: mechanistic insights and bibliometric analysis"],"prefix":"10.3389","volume":"17","author":[{"given":"Pengfei","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Physical Education, Shanghai Dianji University","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Physical Education, Shanghai University of Sport","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaohui","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Physical Education, Shanghai University of Sport","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengcheng","family":"Ji","sequence":"additional","affiliation":[{"name":"School of Artificial Intelligence and Data Science, Shanghai Dianji University","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinbo","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Athletic Performance, Shanghai University of Sport","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11142229","article-title":"Extracellular vesicles, inflammation, and cardiovascular disease","volume":"11","author":"Akhmerov","year":"2022","journal-title":"Cells"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1002\/iub.70082","article-title":"Exosomal lncRNAs in myocardial ischemia: From diagnostic advantage to therapeutic targets","volume":"78","author":"Alshahrani","year":"2026","journal-title":"IUBMB Life"},{"key":"B3","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1152\/physiolgenomics.00155.2025","article-title":"Metabolomic profiling of extracellular vesicles reveals enhanced oxidative stress and energy metabolism during intense military training: An exploratory study","volume":"57","author":"Beckner","year":"2025","journal-title":"Physiol. 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