{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T13:08:34Z","timestamp":1788872914405,"version":"build-2803163510"},"reference-count":72,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100024032","name":"Dipartimento di Biologia, Universit\u00e0 degli Studi di Padova","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100024032","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:p>\n                    The domesticated silkworm\n                    <jats:italic>Bombyx mori<\/jats:italic>\n                    is both a major sericultural species and a powerful model for studying how environmental cues are converted into developmental decisions. A central seasonal trait in this species is embryonic diapause, a maternally programmed developmental arrest whose incidence is shaped by genetic background and environmental conditions experienced during the maternal generation. Recent genome-editing studies have provided new functional evidence for the role of circadian clock genes in this process, particularly the two silkworm cryptochromes, BmCRY1 and BmCRY2. BmCRY1 belongs to the\n                    <jats:italic>Drosophila<\/jats:italic>\n                    -type CRY lineage and retains features consistent with a light-input function, whereas BmCRY2 belongs to the mammalian-type insect CRY lineage and displays structural motifs expected for a nuclear transcriptional repressor. Loss of\n                    <jats:italic>Bmcry1<\/jats:italic>\n                    disrupts embryonic hatching and adult eclosion rhythms and impairs photoperiodic modulation of diapause, while temperature-dependent diapause induction under constant darkness is largely retained. By contrast,\n                    <jats:italic>Bmcry2<\/jats:italic>\n                    mutants show reduced temperature-dependent diapause induction, although the direct role of BmCRY2 in the silkworm clockwork remains unresolved. Together, available evidence suggests that BmCRY1 and BmCRY2 act through distinct clock-related entry points that ultimately influence, directly or indirectly, the neuroendocrine pathway controlling diapause hormone release and maternal diapause commitment. These findings place silkworm cryptochromes at a key interface between environmental sensing, circadian timing and seasonal developmental control, with potential implications for sericulture.\n                  <\/jats:p>","DOI":"10.3389\/fphys.2026.1953101","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:29:45Z","timestamp":1788870585000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Cryptochrome-mediated integration of circadian rhythms into seasonal cycles in the silkworm Bombyx mori"],"prefix":"10.3389","volume":"17","author":[{"given":"Daniel J.","family":"Brady","sequence":"first","affiliation":[{"name":"Fraunhofer Institute for Molecular Biology and Applied Ecology\u2014IME, Branch for Bioresources","place":["Gie\u00dfen, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Sandrelli","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Padova","place":["Padova, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0317572","article-title":"Enhanced silk production and pupal weight in Bombyx mori through CRISPR\/Cas9-mediated circadian Clock gene disruption","volume":"20","author":"Brady","year":"2025","journal-title":"PloS One"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.776826","article-title":"The circadian clock in Lepidoptera","volume":"12","author":"Brady","year":"2021","journal-title":"Front. 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