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Plant Sci."],"abstract":"<jats:p>\n                    Basic helix-loop-helix proteins (bHLHs) comprise one of the largest families of transcription factors in plants. They have been shown to be involved in responses to various abiotic stresses, such as drought, salinity, chilling, heavy metal toxicity, iron deficiency, and osmotic damages. By specifically binding to\n                    <jats:italic>cis<\/jats:italic>\n                    -elements in the promoter region of stress related genes, bHLHs can regulate their transcriptional expression, thereby regulating the plant\u2019s adaptive responses. This review focuses on the structural characteristics of bHLHs, the regulatory mechanism of how bHLHs are involved transcriptional activation, and the mechanism of how bHLHs regulate the transcription of target genes under various stresses. Finally, as increasing research demonstrates that flavonoids are usually induced under fluctuating environments, the latest research progress and future research prospects are described on the mechanisms of how flavonoid biosynthesis is regulated by bHLHs in the regulation of the plant\u2019s responses to abiotic stresses.\n                  <\/jats:p>","DOI":"10.3389\/fpls.2021.677611","type":"journal-article","created":{"date-parts":[[2021,6,18]],"date-time":"2021-06-18T02:43:17Z","timestamp":1623984197000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":212,"title":["Regulatory Mechanisms of bHLH Transcription Factors in Plant Adaptive Responses to Various Abiotic Stresses"],"prefix":"10.3389","volume":"12","author":[{"given":"Yuchen","family":"Qian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongyao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangpeng","family":"Gou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingting","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erxu","family":"Pi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,6,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1859","DOI":"10.1105\/tpc.9.10.18591997","article-title":"Role of arabidopsis MYC and MYB homologs in drought- and abscisic acid-regulated gene expression.","volume":"9","author":"Abe","year":"1997","journal-title":"Plant Cell"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0126872","article-title":"bHLH106 Integrates Functions of Multiple Genes through Their G-Box to Confer Salt Tolerance on Arabidopsis.","volume":"10","author":"Ahmad","year":"2015","journal-title":"PLoS One"},{"key":"B3","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1111\/pce.13408","article-title":"Cold stress signalling in female reproductive tissues.","volume":"42","author":"Albertos","year":"2019","journal-title":"Plant Cell Environ."},{"key":"B4","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.plaphy.2016.06.032","article-title":"The molecular cloning and functional characterization of MdMYC2, a bHLH transcription factor in apple.","volume":"108","author":"An","year":"2016","journal-title":"Plant Physiol. 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