{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T17:31:49Z","timestamp":1793122309930,"version":"4.5.0"},"reference-count":78,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T00:00:00Z","timestamp":1668384000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Plant Sci."],"abstract":"<jats:p>Two previously undescribed lactones, phomolides A and B (<jats:bold>1<\/jats:bold> and <jats:bold>2<\/jats:bold>), and three new sesquiterpenoids, phomenes A\u2013C (<jats:bold>3<\/jats:bold>\u2013<jats:bold>5<\/jats:bold>), together with one known compound, colletotricholide A (<jats:bold>6<\/jats:bold>), were isolated from the endophytic fungus <jats:italic>Phomopsis<\/jats:italic> sp. SZSJ-7B. Their chemical structures, including the absolute configurations, were comprehensively established by extensive analyses of NMR, high-resolution electrospray ionization mass spectrometry, electronic circular dichroism powered by theoretical calculations, and X-ray diffractions. Moreover, the cytotoxic and antibacterial activities of compounds <jats:bold>1\u20136<\/jats:bold> were also evaluated, and the results demonstrated that compound <jats:bold>2<\/jats:bold> showed significant antibacterial effects towards methicillin-resistant <jats:italic>Staphylococcus aureus<\/jats:italic> and <jats:italic>S. aureus<\/jats:italic> strains with minimum inhibitory concentration as low as 6.25 \u03bcg\/ml, which was comparable to that of the clinical drug vancomycin. Moreover, all compounds showed no cytotoxic activity.<\/jats:p>","DOI":"10.3389\/fpls.2022.1049015","type":"journal-article","created":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T06:31:05Z","timestamp":1668407465000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Five new secondary metabolites from an endophytic fungus Phomopsis sp. 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