{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T10:07:39Z","timestamp":1781863659438,"version":"3.54.5"},"reference-count":104,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T00:00:00Z","timestamp":1649894400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2016YFD0200405"],"award-info":[{"award-number":["2016YFD0200405"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Plant Sci."],"abstract":"<jats:p>Iron (Fe) is a limiting factor in crop growth and nutritional quality because of its low solubility. However, the current understanding of how major crops respond to Fe deficiency and the genetic basis remains limited. In the present study, Fe-efficient inbred line Ye478 and Fe-inefficient inbred line Wu312 and their recombinant inbred line (RIL) population were utilized to reveal the physiological and genetic responses of maize to low Fe stress. Compared with the Fe-sufficient conditions (+Fe: 200 \u03bcM), Fe-deficient supply (\u2212Fe: 30 \u03bcM) significantly reduced shoot and root dry weights, leaf SPAD of Fe-efficient inbred line Ye478 by 31.4, 31.8, and 46.0%, respectively; decreased Fe-inefficient inbred line Wu312 by 72.0, 45.1, and 84.1%, respectively. Under Fe deficiency, compared with the supply of calcium nitrate (N1), supplying ammonium nitrate (N2) significantly increased the shoot and root dry weights of Wu312 by 37.5 and 51.6%, respectively; and enhanced Ye478 by 23.9 and 45.1%, respectively. Compared with N1, N2 resulted in a 70.0% decrease of the root Fe concentration for Wu312 in the \u2212Fe treatment, N2 treatment reduced the root Fe concentration of Ye478 by 55.8% in the \u2212Fe treatment. These findings indicated that, compared with only supplying nitrate nitrogen, combined supply of ammonium nitrogen and nitrate nitrogen not only contributed to better growth in maize but also significantly reduced Fe concentration in roots. In linkage analysis, ten quantitative trait loci (QTLs) associated with Fe deficiency tolerance were detected, explaining 6.2\u201312.0% of phenotypic variation. Candidate genes considered to be associated with the mechanisms underlying Fe deficiency tolerance were identified within a single locus or QTL co-localization, including <jats:italic>ZmYS3<\/jats:italic>, <jats:italic>ZmPYE<\/jats:italic>, <jats:italic>ZmEIL3<\/jats:italic>, <jats:italic>ZmMYB153<\/jats:italic>, <jats:italic>ZmILR3<\/jats:italic> and <jats:italic>ZmNAS4<\/jats:italic>, which may form a sophisticated network to regulate the uptake, transport and redistribution of Fe. Furthermore, <jats:italic>ZmYS3<\/jats:italic> was highly induced by Fe deficiency in the roots; <jats:italic>ZmPYE<\/jats:italic> and <jats:italic>ZmEIL3<\/jats:italic>, which may be involved in Fe homeostasis in strategy I plants, were significantly upregulated in the shoots and roots under low Fe stress; <jats:italic>ZmMYB153<\/jats:italic> was Fe-deficiency inducible in the shoots. Our findings will provide a comprehensive insight into the physiological and genetic basis of Fe deficiency tolerance.<\/jats:p>","DOI":"10.3389\/fpls.2022.805247","type":"journal-article","created":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T13:51:18Z","timestamp":1649944278000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Identification of Quantitative Trait Loci Associated With Iron Deficiency Tolerance in Maize"],"prefix":"10.3389","volume":"13","author":[{"given":"Jianqin","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaqing","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuyu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Futong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,4,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1023\/A:1004451728237","article-title":"Photosystem II efficiency in low chlorophyll, iron-deficient leaves.","volume":"215","author":"Abad\u00eda","year":"1999","journal-title":"Plant Soil"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1186\/s12870-015-0561-y","article-title":"Multiple interval QTL mapping and searching for PSTOL1 homologs associated with root morphology, biomass accumulation and phosphorus content in maize seedlings under low-P.","volume":"15","author":"Azevedo","year":"2015","journal-title":"BMC Plant Biol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"61","DOI":"10.13320\/j.cnki.jauh.2020.0053","article-title":"Study of interaction between transcription factor ZmMYB153 and TPL\/TPRs proteins.","volume":"43","author":"Bai","year":"2020","journal-title":"J. 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