{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T01:28:55Z","timestamp":1789176535036,"version":"build-2803163510"},"reference-count":79,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T00:00:00Z","timestamp":1657152000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NSFC31730019"],"award-info":[{"award-number":["NSFC31730019"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NSFC3160096"],"award-info":[{"award-number":["NSFC3160096"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008982","name":"National Science Foundation","doi-asserted-by":"publisher","award":["IOS1121496"],"award-info":[{"award-number":["IOS1121496"]}],"id":[{"id":"10.13039\/501100008982","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["2012CSP004"],"award-info":[{"award-number":["2012CSP004"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Plant Sci."],"abstract":"<jats:p>Endoplasmic reticulum-associated degradation (ERAD) is a key cellular process for degrading misfolded proteins. It was well known that an asparagine (N)-linked glycan containing a free \u03b11,6-mannose residue is a critical ERAD signal created by Homologous to \u03b1-mannosidase 1 (Htm1) in yeast and ER-Degradation Enhancing \u03b1-Mannosidase-like proteins (EDEMs) in mammals. An earlier study suggested that two Arabidopsis homologs of Htm1\/EDEMs function redundantly in generating such a conserved N-glycan signal. Here we report that the Arabidopsis <jats:italic>irb1<\/jats:italic> (<jats:italic>reversal of bri1<\/jats:italic>) mutants accumulate brassinosteroid-insensitive 1\u20135 (bri1\u20135), an ER-retained mutant variant of the brassinosteroid receptor BRI1 and are defective in one of the Arabidopsis Htm1\/EDEM homologs, AtEDEM1. We show that the wild-type AtEDEM1, but not its catalytically inactive mutant, rescues <jats:italic>irb1-1<\/jats:italic>. Importantly, an insertional mutation of the Arabidopsis Asparagine-Linked Glycosylation 3 (ALG3), which causes N-linked glycosylation with truncated glycans carrying a different free \u03b11,6-mannose residue, completely nullifies the inhibitory effect of <jats:italic>irb1-1<\/jats:italic> on bri1-5 ERAD. Interestingly, an insertional mutation in AtEDEM2, the other Htm1\/EDEM homolog, has no detectable effect on bri1-5 ERAD; however, it enhances the inhibitory effect of <jats:italic>irb1-1<\/jats:italic> on bri1-5 degradation. Moreover, <jats:italic>AtEDEM2<\/jats:italic> transgenes rescued the <jats:italic>irb1-1<\/jats:italic> mutation with lower efficacy than <jats:italic>AtEDEM1<\/jats:italic>. Simultaneous elimination of <jats:italic>AtEDEM1<\/jats:italic> and <jats:italic>AtEDEM2<\/jats:italic> completely blocks generation of \u03b11,6-mannose-exposed N-glycans on bri1-5, while overexpression of either <jats:italic>AtEDEM1<\/jats:italic> or <jats:italic>AtEDEM2<\/jats:italic> stimulates bri1-5 ERAD and enhances the <jats:italic>bri1-5<\/jats:italic> dwarfism. We concluded that, despite its functional redundancy with AtEDEM2, AtEDEM1 plays a predominant role in promoting bri1-5 degradation.<\/jats:p>","DOI":"10.3389\/fpls.2022.952246","type":"journal-article","created":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T09:54:33Z","timestamp":1657187673000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["A Predominant Role of AtEDEM1 in Catalyzing a Rate-Limiting Demannosylation Step of an Arabidopsis Endoplasmic Reticulum-Associated Degradation Process"],"prefix":"10.3389","volume":"13","author":[{"given":"Jianjun","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinghe","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yamin","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongwu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Congcong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muyang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Min","family":"She","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinxiang","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef","family":"Voglmeir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuhua","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linchuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,7,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/s10719-011-9362-1","article-title":"In vitro mannose trimming property of human ER alpha-1,2 mannosidase I","volume":"29","author":"Aikawa","year":"2012","journal-title":"Glycoconj. 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