{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T05:54:16Z","timestamp":1773381256805,"version":"3.50.1"},"reference-count":88,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,1,5]],"date-time":"2024-01-05T00:00:00Z","timestamp":1704412800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Plant Sci."],"abstract":"<jats:p>Iron deficiency is a major nutritional problem causing iron deficiency chlorosis (IDC) and yield reduction in soybean, one of the most important crops. The ATP-binding cassette G subfamily plays a crucial role in substance transportation in plants. In this study, we cloned the <jats:italic>GmABCG5<\/jats:italic> gene from soybean and verified its role in Fe homeostasis. Analysis showed that GmABCG5 belongs to the ABCG subfamily and is subcellularly localized at the cell membrane. From high to low, <jats:italic>GmABCG5<\/jats:italic> expression was found in the stem, root, and leaf of young soybean seedlings, and the order of expression was flower, pod, seed stem, root, and leaf in mature soybean plants. The GUS assay and qRT-PCR results showed that the <jats:italic>GmABCG5<\/jats:italic> expression was significantly induced by iron deficiency in the leaf. We obtained the <jats:italic>GmABCG5<\/jats:italic> overexpressed and inhibitory expressed soybean hairy\u00a0root complexes. Overexpression of <jats:italic>GmABCG5<\/jats:italic> promoted, and inhibition of <jats:italic>GmABCG5<\/jats:italic> retarded the growth of soybean hairy roots, independent of nutrient iron conditions, confirming the growth-promotion function of <jats:italic>GmABCG5<\/jats:italic>. Iron deficiency has a negative effect on the growth of soybean complexes, which was more obvious in the <jats:italic>GmABCG5<\/jats:italic> inhibition complexes. The chlorophyll content was increased in the <jats:italic>GmABCG5<\/jats:italic> overexpression complexes and decreased in the <jats:italic>GmABCG5<\/jats:italic> inhibition complexes. Iron deficiency treatment widened the gap in the chlorophyll contents. FCR activity was induced by iron deficiency and showed an extraordinary increase in the <jats:italic>GmABCG5<\/jats:italic> overexpression complexes, accompanied by the greatest Fe accumulation. Antioxidant capacity was enhanced when <jats:italic>GmABCG5<\/jats:italic> was overexpressed and reduced when <jats:italic>GmABCG5<\/jats:italic> was inhibited under iron deficiency. These results showed that the response mechanism to iron deficiency is more actively mobilized in <jats:italic>GmABCG5<\/jats:italic> overexpression seedlings. Our results indicated that <jats:italic>GmABCG5<\/jats:italic> could improve the plant\u2019s tolerance to iron deficiency, suggesting that <jats:italic>GmABCG5<\/jats:italic> might have the function of Fe mobilization, redistribution, and\/or secretion of Fe substances in plants. The findings provide new insights into the ABCG subfamily genes in the regulation of iron homeostasis in plants.<\/jats:p>","DOI":"10.3389\/fpls.2023.1289801","type":"journal-article","created":{"date-parts":[[2024,1,5]],"date-time":"2024-01-05T04:24:32Z","timestamp":1704428672000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["GmABCG5, an ATP-binding cassette G transporter gene, is involved in the iron deficiency response in soybean"],"prefix":"10.3389","volume":"14","author":[{"given":"Yu","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuemeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhan","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingting","family":"Niu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenwei","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongjun","family":"Shu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changhong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donglin","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingdong","family":"Bi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,1,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/s12870-014-0323-2","article-title":"Genetic variability and evolutionary diversification of membrane ABC transporters in plants","volume":"15","author":"Andolfo","year":"2015","journal-title":"BMC. 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