{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T04:16:09Z","timestamp":1792210569624,"version":"4.4.0"},"reference-count":106,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T00:00:00Z","timestamp":1719446400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Plant Sci."],"abstract":"<jats:p>The plants of the genus <jats:italic>Physalis<\/jats:italic> L. have been extensively utilized in traditional and indigenous Chinese medicinal practices for treating a variety of ailments, including dermatitis, malaria, asthma, hepatitis, and liver disorders. The present review aims to achieve a comprehensive and up-to-date investigation of the genus <jats:italic>Physalis<\/jats:italic>, a new model crop, to understand plant diversity and fruit development. Several chloroplast DNA-, nuclear ribosomal DNA-, and genomic DNA-based markers, such as <jats:italic>psbA-trnH<\/jats:italic>, internal-transcribed spacer (ITS), simple sequence repeat (SSR), random amplified microsatellites (RAMS), sequence-characterized amplified region (SCAR), and single nucleotide polymorphism (SNP), were developed for molecular identification, genetic diversity, and phylogenetic studies of <jats:italic>Physalis<\/jats:italic> species. A large number of functional genes involved in inflated calyx syndrome development (<jats:italic>AP2-L<\/jats:italic>, <jats:italic>MPF2<\/jats:italic>, <jats:italic>MPF3<\/jats:italic>, and <jats:italic>MAGO<\/jats:italic>), organ growth (<jats:italic>AG1<\/jats:italic>, <jats:italic>AG2<\/jats:italic>, <jats:italic>POS1<\/jats:italic>, and <jats:italic>CNR1<\/jats:italic>), and active ingredient metabolism (<jats:italic>24ISO<\/jats:italic>, <jats:italic>DHCRT<\/jats:italic>, <jats:italic>P450-CPL<\/jats:italic>, <jats:italic>SR<\/jats:italic>, <jats:italic>DUF538<\/jats:italic>, <jats:italic>TAS14<\/jats:italic>, and <jats:italic>3\u03b2-HSB<\/jats:italic>) were identified contributing to the breeding of novel <jats:italic>Physalis<\/jats:italic> varieties. Various omic studies revealed and functionally identified a series of reproductive organ development-related factors, environmental stress-responsive genes, and active component biosynthesis-related enzymes. The chromosome-level genomes of <jats:italic>Physalis floridana<\/jats:italic> Rydb., <jats:italic>Physalis grisea<\/jats:italic> (Waterf.) M. Mart\u00ednez, and <jats:italic>Physalis pruinosa<\/jats:italic> L. have been recently published providing a valuable resource for genome editing in <jats:italic>Physalis<\/jats:italic> crops. Our review summarizes the recent progress in genetic diversity, molecular identification, phylogenetics, functional genes, and the application of omics in the genus <jats:italic>Physalis<\/jats:italic> and accelerates efficient utilization of this traditional herb.<\/jats:p>","DOI":"10.3389\/fpls.2024.1407625","type":"journal-article","created":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T04:40:31Z","timestamp":1719463231000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Advances in Physalis molecular research: applications in authentication, genetic diversity, phylogenetics, functional genes, and omics"],"prefix":"10.3389","volume":"15","author":[{"given":"Yan","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyun","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyi","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quanzhou","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huizhong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenjia","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shangguo","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,6,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1007\/s10722\u2013021-01278\u20132","article-title":"Genetic diversity and structure in husk tomato based (Physalis philadelphica Lam.) on SNPs: a case of diffuse domestication","volume":"69","author":"Alcala-Gomez","year":"2022","journal-title":"Genet. 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