{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T23:19:31Z","timestamp":1794093571124,"version":"4.8.0"},"reference-count":82,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T00:00:00Z","timestamp":1731542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Plant Sci."],"abstract":"<jats:p>Deep space flight imposes higher levels of damage on biological organisms; however, its specific effects on rice remain unclear. To investigate the variations in DNA methylation under deep space flight conditions, this study examined rice seeds carried by Chang\u2019e-5. After 23 days of lunar orbital flight, the samples were planted in an artificial climate chamber and subjected to transcriptome and DNA methylation sequencing during the tillering and heading stages. The methylation patterns in the rice genome exhibited variability in response to lunar orbital stressors. DNA methylation alters the expression and interaction patterns of functional genes, involving biological processes such as metabolism and defense. Furthermore, we employed single-sample analysis methods to assess the gene expression and interaction patterns of different rice individuals. The genes exhibiting changes at the transcriptional and methylation levels varied among the different plants; however, these genes regulate consistent biological functions, primarily emphasizing metabolic processes. Finally, through single-sample analysis, we identified a set of miRNAs induced by lunar orbital stressors that potentially target DNA methylation regulatory factors. The findings of this study broaden the understanding of space biological effects and lay a foundation for further exploration of the mechanisms by which deep space flight impacts plants.<\/jats:p>","DOI":"10.3389\/fpls.2024.1427578","type":"journal-article","created":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T12:01:49Z","timestamp":1731585709000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Variations in DNA methylation and the role of regulatory factors in rice (Oryza sativa) response to lunar orbit stressors"],"prefix":"10.3389","volume":"15","author":[{"given":"Xiaohui","family":"Du","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeqing","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,11,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.1016\/j.cell.2020.10.050","article-title":"Fundamental biological features of spaceflight: advancing the field to enable deep-space exploration","volume":"183","author":"Afshinnekoo","year":"2020","journal-title":"Cell"},{"key":"B2","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1111\/ppl.v171.4","article-title":"Reassessing the role of ion homeostasis for improving salinity tolerance in crop plants","volume":"171","author":"Basu","year":"2020","journal-title":"Physiol. Plant."},{"key":"B3","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1042\/BJ20140753","article-title":"Plant-driven repurposing of the ancient S-adenosylmethionine repair enzyme homocysteine S-methyltransferase","volume":"463","author":"Bradbury","year":"2014","journal-title":"Biochem. J."},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.00085","article-title":"Stress related shift toward inflammaging in cosmonauts after long-duration space flight","volume":"10","author":"Buchheim","year":"2019","journal-title":"Front. Physiol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1152\/physiolgenomics.00117.2014","article-title":"Transcriptomes reveal alterations in gravity impact circadian clocks and activate mechanotransduction pathways with adaptation through epigenetic change","volume":"47","author":"Casey","year":"2015","journal-title":"Physiol. Genomics"},{"key":"B6","doi-asserted-by":"publisher","first-page":"491","DOI":"10.3390\/life4030491","article-title":"Space radiation: the number one risk to astronaut health beyond low earth orbit","volume":"4","author":"Chancellor","year":"2014","journal-title":"Life (Basel)."},{"key":"B7","doi-asserted-by":"publisher","first-page":"49","DOI":"10.3390\/life10040049","article-title":"Rocket science: the effect of spaceflight on germination physiology, ageing, and transcriptome of eruca sativa seeds","volume":"10","author":"Chandler","year":"2020","journal-title":"Life (Basel)."},{"key":"B8","doi-asserted-by":"publisher","first-page":"6883","DOI":"10.1093\/nar\/gkq590","article-title":"siRNAs from miRNA sites mediate DNA methylation of target genes","volume":"38","author":"Chellappan","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"B9","doi-asserted-by":"publisher","first-page":"4375","DOI":"10.1093\/jxb\/ert243","article-title":"Mn tolerance in rice is mediated by MTP8.1, a member of the cation diffusion facilitator family","volume":"64","author":"Chen","year":"2013","journal-title":"J. Exp. Bot."},{"key":"B10","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.pbi.2013.03.004","article-title":"Rice epigenomics and epigenetics: challenges and opportunities","volume":"16","author":"Chen","year":"2013","journal-title":"Curr. Opin. Plant Biol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1002\/ajb2.2019.106.issue-1","article-title":"Variation in the transcriptome of different ecotypes of Arabidopsis thaliana reveals signatures of oxidative stress in plant responses to spaceflight","volume":"106","author":"Choi","year":"2019","journal-title":"Am. J. Bot."},{"key":"B12","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1038\/nature06745","article-title":"Shotgun bisulphite sequencing of the Arabidopsis genome reveals DNA methylation patterning","volume":"452","author":"Cokus","year":"2008","journal-title":"Nature"},{"key":"B13","doi-asserted-by":"publisher","first-page":"16163","DOI":"10.1038\/nplants.2016.163","article-title":"Non-canonical RNA-directed DNA methylation","volume":"2","author":"Cuerda-Gil","year":"2016","journal-title":"Nat. Plants"},{"key":"B14","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1016\/j.jgg.2018.09.004","article-title":"Retrospective and perspective of plant epigenetics in China","volume":"45","author":"Duan","year":"2018","journal-title":"J. Genet. Genomics"},{"key":"B15","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1046\/j.1365-313X.2003.01661.x","article-title":"OsDREB genes in rice, Oryza sativa L., encode transcription activators that function in drought-, high-salt- and cold-responsive gene expression","volume":"33","author":"Dubouzet","year":"2003","journal-title":"Plant J."},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1009034","article-title":"RNA-directed DNA methylation","volume":"16","author":"Erdmann","year":"2020","journal-title":"PloS Genet."},{"key":"B17","doi-asserted-by":"publisher","first-page":"992","DOI":"10.3390\/genes13060992","article-title":"Plant DNA methylation responds to nutrient stress.pdf","volume":"13","author":"Fan","year":"2022","journal-title":"Genes (Basel)"},{"key":"B18","doi-asserted-by":"publisher","first-page":"2107","DOI":"10.1007\/s00299-022-02917-3","article-title":"Improving pre-harvest sprouting resistance in rice by editing OsABA8ox using CRISPR\/Cas9","volume":"41","author":"Fu","year":"2022","journal-title":"Plant Cell Rep."},{"key":"B19","doi-asserted-by":"publisher","first-page":"106429","DOI":"10.1016\/j.jenvrad.2020.106429","article-title":"Dose-dependent genomic DNA hypermethylation and mitochondrial DNA damage in Japanese tree frogs sampled in the Fukushima Daiichi area","volume":"225","author":"Gombeau","year":"2020","journal-title":"J. Environ. Radioactivity."},{"key":"B20","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1007\/s11103-008-9391-8","article-title":"Rice DREB1B promoter shows distinct stress-specific responses, and the overexpression of cDNA in tobacco confers improved abiotic and biotic stress tolerance","volume":"68","author":"Gutha","year":"2008","journal-title":"Plant Mol. Biol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1186\/s13046-022-02319-z","article-title":"LncRNA-mediated DNA methylation: an emerging mechanism in cancer and beyond","volume":"41","author":"Huang","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"B22","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1038\/nmeth.3317","article-title":"HISAT: a fast spliced aligner with low memory requirements","volume":"12","author":"Kim","year":"2015","journal-title":"Nat. Methods"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1859","DOI":"10.1093\/pcp\/pcu125","article-title":"Epigenetic memory for stress response and adaptation in plants","volume":"55","author":"Kinoshita","year":"2014","journal-title":"Plant Cell Physiol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1080\/09553002.2020.1767819","article-title":"Epigenetic factors of individual radiosensitivity and adaptive capacity","volume":"96","author":"Kravets","year":"2020","journal-title":"Int. J. Radiat. Biol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1186\/s12870-020-02392-6","article-title":"Spaceflight induces novel regulatory responses in Arabidopsis seedling as revealed by combined proteomic and transcriptomic analyses","volume":"20","author":"Kruse","year":"2020","journal-title":"BMC Plant Biol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.isci.2019.03.021","article-title":"Estimating sample-specific regulatory networks","volume":"14","author":"Kuijjer","year":"2019","journal-title":"iScience"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2021.611783","article-title":"Changes in DNA methylation in arabidopsis thaliana plants exposed over multiple generations to gamma radiation","volume":"12","author":"Laanen","year":"2021","journal-title":"Front. Plant Sci."},{"key":"B28","doi-asserted-by":"publisher","first-page":"R25","DOI":"10.1186\/gb-2009-10-3-r25","article-title":"Ultrafast and memory-efficient alignment of short DNA sequences to the human genome","volume":"10","author":"Langmead","year":"2009","journal-title":"Genome Biol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1038\/nature12178","article-title":"Polymerase IV occupancy at RNA-directed DNA methylation sites requires SHH1","volume":"498","author":"Law","year":"2013","journal-title":"Nature"},{"key":"B30","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1038\/nrg2719","article-title":"Establishing, maintaining and modifying DNA methylation patterns in plants and animals","volume":"11","author":"Law","year":"2010","journal-title":"Nat. Rev. Genet."},{"key":"B31","doi-asserted-by":"publisher","first-page":"kuad026","DOI":"10.1093\/jimb\/kuad026","article-title":"Production of S-methyl-methionine using engineered Saccharomyces cerevisiae sake K6","volume":"50","author":"Lee","year":"2023","journal-title":"J. Ind. Microbiol. Biotechnol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1007\/s00299-017-2215-z","article-title":"Active DNA demethylation: mechanism and role in plant development","volume":"37","author":"Li","year":"2017","journal-title":"Plant Cell Rep."},{"key":"B33","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1038\/s41540-023-00267-8","article-title":"Integration of single sample and population analysis for understanding immune evasion mechanisms of lung cancer","volume":"9","author":"Li","year":"2023","journal-title":"NPJ Syst. Biol. Appl."},{"key":"B34","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1186\/s12870-019-1899-3","article-title":"OsZIP1 functions as a metal efflux transporter limiting excess zinc, copper and cadmium accumulation in rice","volume":"19","author":"Liu","year":"2019","journal-title":"BMC Plant Biol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1111\/jipb.12879","article-title":"The mechanism and function of active DNA demethylation in plants","volume":"62","author":"Liu","year":"2019","journal-title":"J. Integr. Plant Biol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"2603","DOI":"10.1105\/tpc.108.060913","article-title":"A novel class of gibberellin 2-oxidases control semidwarfism, tillering, and root development in rice","volume":"20","author":"Lo","year":"2008","journal-title":"Plant Cell"},{"key":"B37","doi-asserted-by":"publisher","first-page":"104687","DOI":"10.1016\/j.isci.2022.104687","article-title":"Recent transcriptomic studies to elucidate the plant adaptive response to spaceflight and to simulated space environments","volume":"25","author":"Manzano","year":"2022","journal-title":"iScience"},{"key":"B38","doi-asserted-by":"publisher","first-page":"20","DOI":"10.15252\/embj.201489499","article-title":"ARGONAUTE 6 bridges transposable element mRNA-derived siRNAs to the establishment of DNA methylation","volume":"34","author":"Mccue","year":"2014","journal-title":"EMBO J."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1966","DOI":"10.1105\/tpc.16.00201","article-title":"Plasma membrane microdomains are essential for rac1-rbohB\/H-mediated immunity in rice","volume":"28","author":"Nagano","year":"2016","journal-title":"Plant Cell"},{"key":"B40","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1104\/pp.113.216481","article-title":"The initiation of epigenetic silencing of active transposable elements is triggered by RDR6 and 21-22 nucleotide small interfering RNAs","volume":"162","author":"Nuthikattu","year":"2013","journal-title":"Plant Physiol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"14425","DOI":"10.3390\/ijms241914425","article-title":"Functional meta-analysis of the proteomic responses of arabidopsis seedlings to the spaceflight environment reveals multi-dimensional sources of variability across spaceflight experiments","volume":"24","author":"Olanrewaju","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"B42","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.mrfmmm.2008.12.004","article-title":"Spaceflight induces both transient and heritable alterations in DNA methylation and gene expression in rice (Oryza sativa L.)","volume":"662","author":"Ou","year":"2009","journal-title":"Mutat. Res."},{"key":"B43","doi-asserted-by":"publisher","first-page":"156","DOI":"10.2478\/jtim-2022-0013","article-title":"Pan-cancer landscape of the RUNX protein family reveals their potential as carcinogenic biomarkers and the mechanisms underlying their action","volume":"10","author":"Pan","year":"2022","journal-title":"J. Trans. Internal Med."},{"key":"B44","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1042\/BST20210336","article-title":"Small regulatory RNAs in rice epigenetic regulation","volume":"50","author":"Park","year":"2022","journal-title":"Biochem. Soc. Trans."},{"key":"B45","doi-asserted-by":"publisher","first-page":"e123","DOI":"10.1093\/nar\/gkp596","article-title":"Transcriptome analysis by strand-specific sequencing of complementary DNA","volume":"37","author":"Parkhomchuk","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"B46","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1038\/nbt.3122","article-title":"StringTie enables improved reconstruction of a transcriptome from RNA-seq reads","volume":"33","author":"Pertea","year":"2015","journal-title":"Nat. Biotechnol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1093\/mp\/ssq030","article-title":"Rice SUVH histone methyltransferase genes display specific functions in chromatin modification and retrotransposon repression","volume":"3","author":"Qin","year":"2010","journal-title":"Mol. Plant"},{"key":"B48","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1007\/s00425-008-0817-y","article-title":"Gene expression changes induced by space flight in single-cells of the fern Ceratopteris richardii","volume":"229","author":"Salmi","year":"2008","journal-title":"Planta"},{"key":"B49","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.3390\/genes14051075","article-title":"Crosstalk between miRNAs and DNA methylation in cancer","volume":"14","author":"Saviana","year":"2023","journal-title":"Genes (Basel)."},{"key":"B50","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1016\/j.cell.2012.10.054","article-title":"Comprehensive analysis of silencing mutants reveals complex regulation of the arabidopsis methylome","volume":"152","author":"Stroud","year":"2013","journal-title":"Cell"},{"key":"B51","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/1471-2229-14-4","article-title":"Genome-wide expression analysis of reactive oxygen species gene network in Mizuna plants grown in long-term spaceflight","volume":"14","author":"Sugimoto","year":"2014","journal-title":"BMC Plant Biol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1111\/tpj.v107.3","article-title":"DNA methylation is involved in acclimation to iron-deficiency in rice (Oryza sativa)","volume":"107","author":"Sun","year":"2021","journal-title":"Plant J."},{"key":"B53","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.abb.2004.08.029","article-title":"Characterization of soluble and putative membrane-bound UDP-glucuronic acid decarboxylase (OsUXS) isoforms in rice","volume":"431","author":"Suzuki","year":"2004","journal-title":"Arch. Biochem. Biophys."},{"key":"B54","doi-asserted-by":"publisher","first-page":"5901","DOI":"10.3390\/ijms22115901","article-title":"Proteomics and post-translational modifications of starch biosynthesis-related proteins in developing seeds of rice","volume":"22","author":"Tappiban","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B55","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1186\/s12870-020-02511-3","article-title":"Identification of small RNAs during cold acclimation in Arabidopsis thaliana","volume":"20","author":"Tiwari","year":"2020","journal-title":"BMC Plant Biol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"4667","DOI":"10.1038\/s41467-019-12266-7","article-title":"A systematic evaluation of single cell RNA-seq analysis pipelines","volume":"10","author":"Vieth","year":"2019","journal-title":"Nat. Commun."},{"key":"B57","doi-asserted-by":"publisher","first-page":"1833","DOI":"10.1126\/science.1074973","article-title":"Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi","volume":"297","author":"Volpe","year":"2002","journal-title":"Science"},{"key":"B58","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1093\/plphys\/kiab531","article-title":"Reinforcement of CHH methylation through RNA-directed DNA methylation ensures sexual reproduction in rice","volume":"188","author":"Wang","year":"2022","journal-title":"Plant Physiol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1104\/pp.112.200279","article-title":"Roles of DICER-LIKE and ARGONAUTE proteins in TAS-derived small interfering RNA-triggered DNA methylation","volume":"160","author":"Wu","year":"2012","journal-title":"Plant Physiol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/j.molcel.2010.03.008","article-title":"DNA methylation mediated by a microRNA pathway","volume":"38","author":"Wu","year":"2010","journal-title":"Mol. Cell"},{"key":"B61","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1038\/s42003-021-02342-4","article-title":"Potential evidence for transgenerational epigenetic memory in Arabidopsis thaliana following spaceflight","volume":"4","author":"Xu","year":"2021","journal-title":"Commun. Biol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1038\/s41526-018-0046-z","article-title":"Single-base resolution methylome analysis shows epigenetic changes in Arabidopsis seedlings exposed to microgravity spaceflight conditions on board the SJ-10 recoverable satellite","volume":"4","author":"Xu","year":"2018","journal-title":"NPJ Microgravity."},{"key":"B63","doi-asserted-by":"publisher","first-page":"1774","DOI":"10.1016\/j.jplph.2007.12.003","article-title":"Alternative splicing of the rice OsMET1 genes encoding maintenance DNA methyltransferase","volume":"165","author":"Yamauchi","year":"2008","journal-title":"J. Plant Physiol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"7273","DOI":"10.1093\/jxb\/erac367","article-title":"A new demethylase gene, OsDML4, is involved in high temperature-increased grain chalkiness in rice","volume":"73","author":"Yan","year":"2022","journal-title":"J. Exp. Bot."},{"key":"B65","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jare.2022.10.001","article-title":"Rhizoctonia solani transcriptional activator interacts with rice WRKY53 and grassy tiller 1 to activate SWEET transporters for nutrition","volume":"50","author":"Yang","year":"2023","journal-title":"J. Adv. Res."},{"key":"B66","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1667\/RR1324.1","article-title":"Bystander\/abscopal effects induced in intact Arabidopsis seeds by low-energy heavy-ion radiation","volume":"170","author":"Yang","year":"2008","journal-title":"Radiat. Res."},{"key":"B67","doi-asserted-by":"publisher","first-page":"5085","DOI":"10.1093\/jxb\/ert298","article-title":"WRKY76 is a rice transcriptional repressor playing opposite roles in blast disease resistance and cold stress tolerance","volume":"64","author":"Yokotani","year":"2013","journal-title":"J. Exp. Bot."},{"key":"B68","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1667\/RR2209.1","article-title":"Detection of changes in DNA methylation induced by low-energy ion implantation in arabidopsis thaliana","volume":"175","author":"Yu","year":"2011","journal-title":"Radiat. Res."},{"key":"B69","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1631\/jzus.B2000519","article-title":"Genome-wide analysis of microRNA156 and its targets, the genes encoding SQUAMOSA promoter-binding protein-like (SPL) transcription factors, in the grass family Poaceae","volume":"22","author":"Yue","year":"2021","journal-title":"J. Zhejiang. University-SCI. B."},{"key":"B70","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.lssr.2020.02.001","article-title":"Proteomic analysis in different development stages on SP0 generation of rice seeds after space flight","volume":"26","author":"Zeng","year":"2020","journal-title":"Life Sci. Space. Res. (Amst)."},{"key":"B71","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1080\/09553002.2024.2327393","article-title":"Construction of dose prediction model and identification of sensitive genes for space radiation based on single-sample networks under spaceflight conditions","volume":"100","author":"Zhang","year":"2024","journal-title":"Int. J. Radiat. Biol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1038\/s41580-018-0016-z","article-title":"Dynamics and function of DNA methylation in plants","volume":"19","author":"Zhang","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B73","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1016\/j.cj.2019.08.006","article-title":"OsABA8ox2, an ABA catabolic gene, suppresses root elongation of rice seedlings and contributes to drought response","volume":"8","author":"Zhang","year":"2020","journal-title":"Crop J."},{"key":"B74","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1111\/tpj.v112.2","article-title":"The OsWRKY63\u2013OsWRKY76\u2013OsDREB1B module regulates chilling tolerance in rice","volume":"112","author":"Zhang","year":"2022","journal-title":"Plant J."},{"key":"B75","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/s41526-024-00383-7","article-title":"Using single-sample networks to identify the contrasting patterns of gene interactions and reveal the radiation dose-dependent effects in multiple tissues of spaceflight mice","volume":"10","author":"Zhang","year":"2024","journal-title":"NPJ Microgravity."},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaz1334","article-title":"First measurements ofthe radiation dose on the lunar surface","volume":"6","author":"Zhang S","year":"2020","journal-title":"Sci. ADV."},{"key":"B77","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.1016\/j.molp.2021.06.006","article-title":"DNA demethylases remodel DNA methylation in rice gametes and zygote and are required for reproduction","volume":"14","author":"Zhou","year":"2021","journal-title":"Mol. Plant"},{"key":"B78","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1186\/s12864-019-5554-z","article-title":"Epigenomics in an extraterrestrial environment: organ-specific alteration of DNA methylation and gene expression elicited by spaceflight in Arabidopsis thaliana","volume":"20","author":"Zhou","year":"2019","journal-title":"BMC Genomics"},{"key":"B79","doi-asserted-by":"publisher","first-page":"1690","DOI":"10.1002\/2017JA024697","article-title":"Radiation measured for chinese satellite SJ-10 space mission","volume":"123","author":"Zhou","year":"2018","journal-title":"J. Geophys. Res.: Space. Phys."},{"key":"B80","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1146\/annurev-genet-102108-134205","article-title":"Active DNA demethylation mediated by DNA glycosylases","volume":"43","author":"Zhu","year":"2009","journal-title":"Annu. Rev. Genet."},{"key":"B81","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1093\/pcp\/pcp022","article-title":"Glucose-induced delay of seed germination in rice is mediated by the suppression of ABA catabolism rather than an enhancement of ABA biosynthesis","volume":"50","author":"Zhu","year":"2009","journal-title":"Plant Cell Physiol."},{"key":"B82","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1038\/ng1929","article-title":"Genome-wide analysis of Arabidopsis thaliana DNA methylation uncovers an interdependence between methylation and transcription","volume":"39","author":"Zilberman","year":"2006","journal-title":"Nat. Genet."}],"container-title":["Frontiers in Plant Science"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpls.2024.1427578\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T12:02:02Z","timestamp":1731585722000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpls.2024.1427578\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,14]]},"references-count":82,"alternative-id":["10.3389\/fpls.2024.1427578"],"URL":"https:\/\/doi.org\/10.3389\/fpls.2024.1427578","relation":{},"ISSN":["1664-462X"],"issn-type":[{"value":"1664-462X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,14]]},"article-number":"1427578"}}