{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T15:33:36Z","timestamp":1792251216754,"version":"4.4.0"},"reference-count":122,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T00:00:00Z","timestamp":1743984000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Plant Sci."],"abstract":"<jats:p>Faba bean is a key protein feed and food worldwide that still requires accurate genomic tools to facilitate molecular marker-assisted breeding. Efficient quantitative trait locus (QTL) mapping in faba bean is restricted by the low or medium density of most of the available genetic maps. In this study, a recombinant inbred line faba bean population including 124 lines from the cross Vf6 x Vf27, highly segregating for autofertility, flowering time, plant architecture, dehiscence, and yield-related traits, was genotyped using the \u2018Vfaba_v2\u2019 SNP array. Genotypic data were used to generate a high-density genetic map that, after quality control and filtering, included 2,296 SNP markers. The final map consisted of 1,674 bin markers distributed across the six faba bean chromosomes, covering 2,963.87 cM with an average marker distance of 1.77 cM. A comparison of the physical and genetic maps revealed a good correspondence between chromosomes and linkage groups. QTL analysis of 66 segregating traits, previously phenotyped in different environments and years, identified 99 significant QTLs corresponding to 35 of the traits. Most QTLs were stable over the years and QTLs for highly correlated traits were mapped to the same or adjacent genomic regions. Colocalization of QTLs occurred in 13 major regions, joining three or more overlapping QTLs. Some of the pleiotropic QTL regions, especially in chromosome VI, shared the same significant marker for different traits related to pollen quantity and size, number of ovules per ovary, seeds per pod, and pod set. Finally, several putative candidate genes for yield-related traits, recently identified using a genome-wide association study, fall inside the colocalizing groups described in this study, indicating that, apart from refining the position of the QTLs and the detection of candidates, the dense new map provides a valuable tool for validation of causative loci derived from association studies and will help advance breeding programs in this crop.<\/jats:p>","DOI":"10.3389\/fpls.2025.1457812","type":"journal-article","created":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T05:14:16Z","timestamp":1744002856000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["A high-density linkage map and fine QTL mapping of architecture, phenology, and yield-related traits in faba bean (Vicia faba L.)"],"prefix":"10.3389","volume":"16","author":[{"given":"David","family":"Aguilar-Benitez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Gutierrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In\u00e9s","family":"Casimiro-Soriguer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana M.","family":"Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,4,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1038\/s41598-021-03861-0","article-title":"Genomic regions associated with herbicide tolerance in a worldwide faba bean (Vicia faba L.) collection","volume":"12","author":"Abou-Khater","year":"2022","journal-title":"Sci. Rep."},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2021.744259","article-title":"Conventional and molecular breeding tools for accelerating genetic gain in faba bean (vicia faba L.)","volume":"12","author":"Adhikari","year":"2021","journal-title":"Front. Plant Sci."},{"key":"B3","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1186\/s12870-022-03499-8","article-title":"Study and QTL mapping of reproductive and morphological traits implicated in the autofertility of faba bean","volume":"22","author":"Aguilar-Benitez","year":"2022","journal-title":"BMC Plant Biol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"17678","DOI":"10.1038\/s41598-020-74750-1","article-title":"First approach to pod dehiscence in faba bean: genetic and histological analyses","volume":"10","author":"Aguilar-Benitez","year":"2020","journal-title":"Sci. Rep."},{"key":"B5","doi-asserted-by":"publisher","first-page":"13716","DOI":"10.1038\/s41598-021-92680-4","article-title":"Linkage mapping and QTL analysis of flowering time in faba bean","volume":"11","author":"Aguilar-Benitez","year":"2021","journal-title":"Sci. Rep."},{"key":"B6","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1007\/s11032-020-01117-9","article-title":"Genetic analysis reveals PDH1 as a candidate gene for control of pod dehiscence in chickpea","volume":"40","author":"Aguilar-Benitez","year":"2020","journal-title":"Mol. Breed."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.2135\/cropsci2015.08.0503","article-title":"Association analyses to genetically improve drought and freezing tolerance of faba bean (Vicia faba L.)","volume":"56","author":"Ali","year":"2016","journal-title":"Crop Sci."},{"key":"B8","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1385\/1-59745-003-0:79","article-title":"QTL analysis","volume-title":"Arabidopsis protocols","author":"Alonso-Blanco","year":"2006"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1104\/pp.18.00745","article-title":"Evidence for the regulation of gynoecium morphogenesis by ETTIN via cell wall dynamics","volume":"178","author":"Andres-Robin","year":"2018","journal-title":"Plant Physiol."},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2017.00679","article-title":"Genotyping-by-sequencing and its exploitation for forage and cool-season grain legume breeding","volume":"8","author":"Annicchiarico","year":"2017","journal-title":"Front. Plant Sci."},{"key":"B11","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1007\/s10681-008-9654-0","article-title":"Quantitative trait loci of frost tolerance and physiologically related trait in faba bean (Vicia faba L.)","volume":"164","author":"Arbaoui","year":"2008","journal-title":"Euphytica"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.126833","article-title":"Genome-wide survey, molecular evolution and expression analysis of Auxin Response Factor (ARF) gene family indicating their key role in seed number per pod in pigeonpea (C. cajan L. Millsp.)","volume":"253","author":"Arpita","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1071\/CP15227","article-title":"QTLs for ascochyta blight resistance in faba bean (Vicia faba L.): validation in field and controlled conditions","volume":"67","author":"Atienza","year":"2016","journal-title":"Crop Pasture Sci."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1007\/s00122-007-0633-y","article-title":"Development of a new diagnostic marker for growth habit selection in faba bean (Vicia faba L.) breeding","volume":"115","author":"Avila","year":"2007","journal-title":"Theor. Appl. Genet."},{"key":"B15","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1007\/s11032-005-4075-4","article-title":"Development of a Simple PCR-based Marker for the Determination of Growth Habit in Vicia faba L. using a Candidate Gene Approach","volume":"17","author":"Avila","year":"2006","journal-title":"Mol. Breed."},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1007\/s11032-017-0688-7","article-title":"Identification of plant architecture and yield-related QTL in Vicia faba L","volume":"37","author":"Avila","year":"2017","journal-title":"Mol. Breed."},{"key":"B17","first-page":"65","article-title":"QTL detection for agronomic traits in faba bean (Vicia faba L.)","volume":"70","author":"Avila","year":"2005","journal-title":"Agric Consp Sci."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1007\/s00122-003-1514-7","article-title":"Isolate and organ-specific QTLs for ascochyta blight resistance in faba bean (Vicia faba L)","volume":"108","author":"Avila","year":"2004","journal-title":"Theor. Appl. Genet."},{"key":"B19","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.pbi.2016.11.008","article-title":"Shattering fruits: variations on a dehiscent theme","volume":"35","author":"Ballester","year":"2017","journal-title":"Curr. Opin. Plant Biol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1958","DOI":"10.1105\/tpc.111.083121","article-title":"A member of the PLEIOTROPIC DRUG RESISTANCE family of ATP binding cassette transporters is required for the formation of a functional cuticle in Arabidopsis","volume":"23","author":"Bessire","year":"2011","journal-title":"Plant Cell"},{"key":"B21","doi-asserted-by":"publisher","first-page":"2390","DOI":"10.1016\/j.cub.2022.04.031","article-title":"Ethylene plays a dual role in sex determination and fruit shape in cucurbits","volume":"32","author":"Boualem","year":"2022","journal-title":"Curr. Biol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"2633","DOI":"10.1093\/bioinformatics\/btm308","article-title":"TASSEL: software for association mapping of complex traits in diverse samples","volume":"23","author":"Bradbury","year":"2007","journal-title":"Bioinformatics"},{"key":"B23","doi-asserted-by":"publisher","first-page":"507","DOI":"10.2135\/cropsci1980.0011183X002000040022x","article-title":"Use of pod width for indirect selection of seed weight in soybeans1","volume":"20","author":"Bravo","year":"1980","journal-title":"Crop Sci."},{"key":"B24","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1093\/bioinformatics\/btg112","article-title":"R\/qtl: QTL mapping in experimental crosses","volume":"19","author":"Broman","year":"2003","journal-title":"Bioinformatics"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1104\/pp.110.171371","article-title":"Distribution of callose synthase, cellulose synthase, and sucrose synthase in tobacco pollen tube is controlled in dissimilar ways by actin filaments and microtubules","volume":"155","author":"Cai","year":"2011","journal-title":"Plant Physiol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"6790","DOI":"10.1038\/s41598-020-63664-7","article-title":"Development of new genetic resources for faba bean (Vicia faba L.) breeding through the discovery of gene-based SNP markers and the construction of a high-density consensus map","volume":"10","author":"Carrillo-Perdomo","year":"2020","journal-title":"Sci. Rep."},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.3390\/plants13111443","article-title":"Transcriptome analysis of stigmas of Vicia faba L. Flowers","volume":"13","author":"Casimiro-Soriguer","year":"2024","journal-title":"Plants"},{"key":"B28","doi-asserted-by":"publisher","first-page":"2952","DOI":"10.1105\/tpc.106.049981","article-title":"The Arabidopsis E3 SUMO ligase SIZ1 regulates plant growth and drought responses","volume":"19","author":"Catala","year":"2007","journal-title":"Plant Cell"},{"key":"B29","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1007\/s10681-017-1910-8","article-title":"QTL detection for flowering time in faba bean and the responses to ambient temperature and photoperiod","volume":"213","author":"Catt","year":"2017","journal-title":"Euphytica"},{"key":"B30","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1159\/000132186","article-title":"Report of the committee on methods of linkage analysis and reporting","volume":"40","author":"Conneally","year":"1985","journal-title":"Cytogenet. Cell Genet."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1767","DOI":"10.1007\/s00122-012-1952-1","article-title":"Comparative genomics to bridge Vicia faba with model and closely-related legume species: stability of QTLs for flowering and yield-related traits","volume":"125","author":"Cruz-Izquierdo","year":"2012","journal-title":"Theor. Appl. Genet."},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2016.02037","article-title":"Identification and characterization of segregation distortion loci on cotton chromosome 18","volume":"7","author":"Dai","year":"2016","journal-title":"Front. Plant Sci."},{"key":"B33","first-page":"2718","article-title":"Mapping of quantitative trait loci controlling Orobanche foetida Poir. resistance in faba bean (Vicia faba L.)","volume":"8","author":"D\u00edaz-Ruiz","year":"2009","journal-title":"Afr. J. Of Biotechnol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1007\/s00122-009-1220-1","article-title":"Validation of QTLs for Orobanche crenata resistance in faba bean (Vicia faba L.) across environments and generations","volume":"120","author":"D\u00edaz-Ruiz","year":"2010","journal-title":"Theor. Appl. Genet."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.1093\/jxb\/eraa553","article-title":"Pod indehiscence in common bean is associated with the fine regulation of PvMYB26","volume":"72","author":"Di Vittori","year":"2021","journal-title":"J. Exp. Bot."},{"key":"B36","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1111\/j.1439-037X.2005.00171.x","article-title":"Flowering, pod set and reproductive success in soya bean","volume":"191","author":"Egli","year":"2005","journal-title":"J. Agro. Crop Sci."},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-9-380","article-title":"Construction of a comparative genetic map in faba bean (Vicia faba L.); conservation of genome structure with Lens culinaris","volume":"9","author":"Ellwood","year":"2008","journal-title":"BMC Genomics"},{"key":"B38","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1111\/nph.13608","article-title":"The ABCG transporter PEC1\/ABCG32 is required for the formation of the developing leaf cuticle in Arabidopsis","volume":"209","author":"Fabre","year":"2016","journal-title":"New Phytol."},{"key":"B39","unstructured":"FAOSTAT\n          \n          \n          \n          2022"},{"key":"B40","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1111\/pbr.12918","article-title":"Genetic study of the resistance of faba bean (Vicia faba) against the fungus Ascochyta fabae through a genome-wide association analysis","volume":"140","author":"Faridi","year":"2021","journal-title":"Plant Breed."},{"key":"B41","doi-asserted-by":"publisher","first-page":"17797","DOI":"10.1073\/pnas.1417282111","article-title":"Molecular basis of a shattering resistance boosting global dissemination of soybean","volume":"111","author":"Funatsuki","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.3390\/horticulturae9070836","article-title":"Construction of a high-density genetic linkage map based on bin markers and mapping of QTLs associated with fruit size in Jujube (Ziziphus jujuba mill.)","volume":"9","author":"Guo","year":"2023","journal-title":"Horticulturae"},{"key":"B43","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1007\/s00122-006-0410-3","article-title":"CAPs markers to assist selection for low vicine and convicine contents in faba bean (Vicia faba L.)","volume":"114","author":"Gutierrez","year":"2006","journal-title":"Theor. Appl. Genet."},{"key":"B44","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1071\/AR07019","article-title":"Development of SCAR markers linked to zt-2, one of the genes controlling absence of tannins in faba bean","volume":"59","author":"Gutierrez","year":"2008","journal-title":"Aust. J. Agric. Res."},{"key":"B45","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1007\/s11032-006-9063-9","article-title":"Development of SCAR markers linked to a gene controlling absence of tannins in faba bean","volume":"19","author":"Gutierrez","year":"2007","journal-title":"Mol. Breed."},{"key":"B46","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1007\/s11032-013-9920-2","article-title":"QTLs for Orobanche spp. resistance in faba bean: identification and validation across different environments","volume":"32","author":"Gutierrez","year":"2013","journal-title":"Mol. Breed."},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2023.1091875","article-title":"Genome-wide association analysis for drought tolerance and associated traits in faba bean (Vicia faba L.)","volume":"14","author":"Gutierrez","year":"2023","journal-title":"Front. Plant Sci."},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2024.1328690","article-title":"Genome-wide association study for yield-related traits in faba bean (Vicia faba L.)","volume":"15","author":"Gutierrez","year":"2024","journal-title":"Front. Plant Sci."},{"key":"B49","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1186\/s12870-021-03335-5","article-title":"QTL dissection and mining of candidate genes for Ascochyta fabae and Orobanche crenata resistance in faba bean (Vicia faba L.)","volume":"21","author":"Gutierrez","year":"2021","journal-title":"BMC Plant Biol."},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2014.00484","article-title":"Genotyping-by-sequencing (GBS), an ultimate marker-assisted selection (MAS) tool to accelerate plant breeding","volume":"5","author":"He","year":"2014","journal-title":"Front. Plant Sci."},{"key":"B51","doi-asserted-by":"publisher","first-page":"3312","DOI":"10.1105\/tpc.108.059568","article-title":"Type B phosphatidylinositol-4-phosphate 5-kinases mediate Arabidopsis and Nicotiana tabacum pollen tube growth by regulating apical pectin secretion","volume":"20","author":"Ischebeck","year":"2008","journal-title":"Plant Cell"},{"key":"B52","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1038\/s41586-023-05791-5","article-title":"The giant diploid faba genome unlocks variation in a global protein crop","volume":"615","author":"Jayakodi","year":"2023","journal-title":"Nature"},{"key":"B53","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1093\/nar\/gky1205","article-title":"AtTrm5a catalyses 1-methylguanosine and 1-methylinosine formation on tRNAs and is important for vegetative and reproductive growth in Arabidopsis thaliana","volume":"47","author":"Jin","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"B54","doi-asserted-by":"publisher","first-page":"1562","DOI":"10.3390\/ijms21051562","article-title":"Mut9p-LIKE KINASE family members: new roles of the plant-specific casein kinase I in plant growth and development","volume":"21","author":"Kang","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B55","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1111\/tpj.16490","article-title":"Redundant function of the Arabidopsis phosphatidylinositol 4-phosphate 5-kinase genes PIP5K4-6 is essential for pollen germination","volume":"117","author":"Kato","year":"2024","journal-title":"Plant J."},{"key":"B56","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.plantsci.2013.11.014","article-title":"SNP discovery and high-density genetic mapping in faba bean (Vicia faba L.) permits identification of QTLs for ascochyta blight resistance","author":"Kaur","year":"2014","journal-title":"Plant Sci."},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1101\/517953","article-title":"Integrating past, present and future wheat research with Pretzel","author":"Keeble-Gagn\u00e8re","year":"2019","journal-title":"BioRxiv"},{"key":"B58","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1242\/dev.067918","article-title":"ETTIN (ARF3) physically interacts with KANADI proteins to form a functional complex essential for integument development and polarity determination in Arabidopsis","volume":"139","author":"Kelley","year":"2012","journal-title":"Development"},{"key":"B59","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.ejbt.2019.02.004","article-title":"Transcriptome profiling of faba bean (Vicia faba L.) drought-tolerant variety hassawi-2 under drought stress using RNA sequencing","volume":"39","author":"Khan","year":"2019","journal-title":"Electron. J. Biotechnol."},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1002\/leg3.75","article-title":"Recent advances in faba bean genetic and genomic tools for crop improvement","volume":"3","author":"Khazaei","year":"2021","journal-title":"Legume Sci."},{"key":"B61","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1105\/tpc.014407","article-title":"SETH1 and SETH2, two components of the glycosylphosphatidylinositol anchor biosynthetic pathway, are required for pollen germination and tube growth in Arabidopsis","volume":"16","author":"Lalanne","year":"2004","journal-title":"Plant Cell"},{"key":"B62","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1023\/B:PLAN.0000019074.60542.6c","article-title":"Mutation of a family 8 glycosyltransferase gene alters cell wall carbohydrate composition and causes a humidity-sensitive semi-sterile dwarf phenotype in Arabidopsis","volume":"53","author":"Lao","year":"2003","journal-title":"Plant Mol. Biol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"2095","DOI":"10.1016\/j.jia.2023.01.003","article-title":"Construction of SNP genetic map based on targeted next-generation sequencing and QTL mapping of vital agronomic traits in faba bean (Vicia faba L.)","volume":"22","author":"Li","year":"2023","journal-title":"J. Integr. Agric."},{"key":"B64","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1111\/pbi.13011","article-title":"Maternal control of seed weight in rapeseed (Brassica napus L.): the causal link between the size of pod (mother, source) and seed (offspring, sink)","volume":"17","author":"Li","year":"2019","journal-title":"Plant Biotechnol. J."},{"key":"B65","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1007\/s00122-011-1617-5","article-title":"Prevalence of segregation distortion in diploid alfalfa and its implications for genetics and breeding applications","volume":"123","author":"Li","year":"2011","journal-title":"Theor. Appl. Genet."},{"key":"B66","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1111\/tpj.12348","article-title":"TCP3 interacts with R2R3-MYB proteins, promotes flavonoid biosynthesis and negatively regulates the auxin response in Arabidopsis thaliana","volume":"76","author":"Li","year":"2013","journal-title":"Plant J."},{"key":"B67","doi-asserted-by":"publisher","first-page":"21094","DOI":"10.1038\/s41598-021-00506-0","article-title":"Unraveling the complexity of faba bean (Vicia faba L.) transcriptome to reveal cold-stress-responsive genes using long-read isoform sequencing technology","volume":"11","author":"Lyu","year":"2021","journal-title":"Sci. Rep."},{"key":"B68","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1111\/pbr.12074","article-title":"Genetic linkage map of Chinese native variety faba bean (Vicia faba L.) based on simple sequence repeat markers","volume":"132","author":"Ma","year":"2013","journal-title":"Plant Breed."},{"key":"B69","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.3390\/plants11091108","article-title":"Genetic dissection of heat stress tolerance in faba bean (Vicia faba L.) using GWAS","volume":"11","author":"Maalouf","year":"2022","journal-title":"Plants"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0143424","article-title":"In depth characterization of repetitive DNA in 23 plant genomes reveals sources of genome size variation in the legume tribe fabeae","volume":"10","author":"Macas","year":"2015","journal-title":"PloS One"},{"key":"B71","doi-asserted-by":"publisher","first-page":"1573","DOI":"10.1105\/tpc.113.109306","article-title":"oiwa, a female gametophytic mutant impaired in a mitochondrial manganese-superoxide dismutase, reveals crucial roles for reactive oxygen species during embryo sac development and fertilization in Arabidopsis","volume":"25","author":"Martin","year":"2013","journal-title":"Plant Cell"},{"key":"B72","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.cj.2015.01.001","article-title":"QTL IciMapping: Integrated software for genetic linkage map construction and quantitative trait locus mapping in biparental populations","volume":"3","author":"Meng","year":"2015","journal-title":"Crop J."},{"key":"B73","doi-asserted-by":"publisher","first-page":"2383","DOI":"10.1534\/g3.115.021667","article-title":"Linkimpute: fast and accurate genotype imputation for nonmodel organisms","volume":"5","author":"Money","year":"2015","journal-title":"G3 (Bethesda)"},{"key":"B74","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1111\/nph.12774","article-title":"Transcriptomic and lipidomic profiles of glycerolipids during Arabidopsis flower development","volume":"203","author":"Nakamura","year":"2014","journal-title":"New Phytol."},{"key":"B75","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1046\/j.1365-313x.1997.12040851.x","article-title":"A nuclear gene, erd1, encoding a chloroplast-targeted Clp protease regulatory subunit homolog is not only induced by water stress but also developmentally up-regulated during senescence in Arabidopsis thaliana","volume":"12","author":"Nakashima","year":"1997","journal-title":"Plant J."},{"key":"B76","author":"O\u2019Sullivan","year":"2019"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0135143","article-title":"Large-Scale Transcriptome Analysis in faba Bean (Vicia faba L.) under Ascochyta fabae Infection","volume":"10","author":"Oca\u00f1a","year":"2015","journal-title":"PLoS One"},{"key":"B78","doi-asserted-by":"publisher","first-page":"2271","DOI":"10.1007\/s00122-017-2958-5","article-title":"Saturation mapping of regions determining resistance to Ascochyta blight and broomrape in faba bean using transcriptome-based SNP genotyping","volume":"130","author":"Oca\u00f1a-Moral","year":"2017","journal-title":"Theor. Appl. Genet."},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2024.1348014","article-title":"Novel SNP markers for flowering and seed quality traits in faba bean (Vicia faba L.): characterization and GWAS of a diversity panel","volume":"15","author":"Ohm","year":"2024","journal-title":"Front. Plant Sci."},{"key":"B80","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1093\/bioinformatics\/btx576","article-title":"LinkageMapView-rendering high-resolution linkage and QTL maps","volume":"34","author":"Ouellette","year":"2018","journal-title":"Bioinformatics"},{"key":"B81","doi-asserted-by":"publisher","first-page":"15566","DOI":"10.1073\/pnas.0706592104","article-title":"Genetic evidence for three unique components in primary cell-wall cellulose synthase complexes in Arabidopsis","volume":"104","author":"Persson","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B82","unstructured":"Peterson\n              B. G.\n            \n            \n              Carl\n              P.\n            \n          \n          PerformanceAnalytics: Econometric tools for performance and risk analysis.\n          \n          2020"},{"key":"B83","doi-asserted-by":"publisher","first-page":"12965","DOI":"10.3390\/ijms222312965","article-title":"Molecular network for regulation of ovule number in plants","volume":"22","author":"Qadir","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B84","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1186\/s12870-020-02467-4","article-title":"ABC1K10a, an atypical kinase, functions in plant salt stress tolerance","volume":"20","author":"Qin","year":"2020","journal-title":"BMC Plant Biol."},{"key":"B85","doi-asserted-by":"publisher","first-page":"eplantgenome2014.07.0028","DOI":"10.3835\/plantgenome2014.07.0028","article-title":"Faba bean: transcriptome analysis from etiolated seedling and developing seed coat of key cultivars for synthesis of proanthocyanidins, phytate, raffinose family oligosaccharides, vicine, and convicine","volume":"8","author":"Ray","year":"2015","journal-title":"Plant Genome"},{"key":"B86","volume-title":"R: a language and environment for statistical computing","year":"2022"},{"key":"B87","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1111\/j.1365-313X.2010.04468.x","article-title":"AtNUFIP, an essential protein for plant development, reveals the impact of snoRNA gene organisation on the assembly of snoRNPs and rRNA methylation in Arabidopsis thaliana","volume":"65","author":"Rodor","year":"2011","journal-title":"Plant J."},{"key":"B88","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1071\/AR02034","article-title":"Locating genes associated with Ascochyta fabae resistance in Vicia faba","volume":"54","author":"Rom\u00e1n","year":"2003","journal-title":"Aust. J. Agric. Res."},{"key":"B89","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1007\/s00122-003-1515-6","article-title":"Development of a composite map in Vicia faba, breeding applications and future prospects","volume":"108","author":"Rom\u00e1n","year":"2004","journal-title":"Theor. Appl. Genet."},{"key":"B90","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1139\/g02-082","article-title":"Mapping of quantitative trait loci controlling broomrape (Orobanche crenata Forsk.) resistance in faba bean (Vicia faba L.)","volume":"45","author":"Rom\u00e1n","year":"2002","journal-title":"Genome"},{"key":"B91","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1071\/CP15200","article-title":"Association mapping of winter hardiness and yield traits in faba bean (Vicia faba L.)","volume":"67","author":"Sallam","year":"2016","journal-title":"Crop Pasture Sci."},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2022.907267","article-title":"Genome-wide association mapping for root traits associated with frost tolerance in faba beans using KASP-SNP markers","volume":"13","author":"Sallam","year":"2022","journal-title":"Front. Genet."},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-14-932","article-title":"A reference consensus genetic map for molecular markers and economically important traits in faba bean (Vicia faba L.)","volume":"14","author":"Satovic","year":"2013","journal-title":"BMC Genomics"},{"key":"B94","doi-asserted-by":"publisher","first-page":"4481","DOI":"10.1242\/dev.124.22.4481","article-title":"ETTIN patterns the Arabidopsis floral meristem and reproductive organs","volume":"124","author":"Sessions","year":"1997","journal-title":"Development"},{"key":"B95","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1046\/j.1365-313x.2003.01624.x","article-title":"Two different novel cis-acting elements of erd1, a clpA homologous Arabidopsis gene function in induction by dehydration stress and dark-induced senescence","volume":"33","author":"Simpson","year":"2003","journal-title":"Plant J."},{"key":"B96","doi-asserted-by":"publisher","first-page":"4114","DOI":"10.1104\/pp.104.053835","article-title":"Inactivation of the clpC1 gene encoding a chloroplast Hsp100 molecular chaperone causes growth retardation, leaf chlorosis, lower photosynthetic activity, and a specific reduction in photosystem content","volume":"136","author":"Sj\u00f6gren","year":"2004","journal-title":"Plant Physiol."},{"key":"B97","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1007\/s00122-023-04360-8","article-title":"Genetic analysis of global faba bean diversity, agronomic traits and selection signatures","volume":"136","author":"Skovbjerg","year":"2023","journal-title":"Theor. Appl. Genet."},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2019.01104","article-title":"Complex horticultural quality traits in broccoli are illuminated by evaluation of the immortal boltbdh mapping population","volume":"10","author":"Stansell","year":"2019","journal-title":"Front. Plant Sci."},{"key":"B99","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1242\/dev.129.5.1131","article-title":"MAX1 and MAX2 control shoot lateral branching in Arabidopsis","volume":"129","author":"Stirnberg","year":"2002","journal-title":"Development"},{"key":"B100","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1007\/s10681-019-2365-x","article-title":"Construction of an integrated genetic linkage map and detection of quantitative trait loci for ascochyta blight resistance in faba bean (Vicia faba L.)","volume":"215","author":"Sudheesh","year":"2019","journal-title":"Euphytica"},{"key":"B101","doi-asserted-by":"publisher","first-page":"2618","DOI":"10.1105\/tpc.113.114322","article-title":"Arabidopsis casein kinase1 proteins CK1.3 and CK1.4 phosphorylate cryptochrome2 to regulate blue light signaling","volume":"25","author":"Tan","year":"2013","journal-title":"Plant Cell"},{"key":"B102","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1007\/BF00215032","article-title":"Linkage among isozyme, RFLP and RAPD markers in Vicia faba","volume":"85","author":"Torres","year":"1993","journal-title":"Theor. Appl. Genet."},{"key":"B103","doi-asserted-by":"publisher","first-page":"1260","DOI":"10.1007\/s00122-005-0043-y","article-title":"Effect of population size on the estimation of QTL: a test using resistance to barley stripe rust","volume":"111","author":"Vales","year":"2005","journal-title":"Theor. Appl. Genet."},{"key":"B104","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1111\/j.1365-313X.2004.02222.x","article-title":"Molecular dissection of plant cytokinesis and phragmoplast structure: a survey of GFP-tagged proteins","volume":"40","author":"Van Damme","year":"2004","journal-title":"Plant J."},{"key":"B105","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1007\/BF00227388","article-title":"Accuracy of mapping quantitative trait loci in autogamous species","volume":"84","author":"van Ooijen","year":"1992","journal-title":"Theor. Appl. Genet."},{"key":"B106","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1007\/s00122-018-3252-x","article-title":"Toward the sequence-based breeding in legumes in the post-genome sequencing era","volume":"132","author":"Varshney","year":"2019","journal-title":"Theor. Appl. Genet."},{"key":"B107","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1007\/s001220051129","article-title":"Development of a genetic composite map of Vicia faba using F2 populations derived from trisomic plants","volume":"98","author":"Vaz Patto","year":"1999","journal-title":"Theor. Appl. Genet."},{"key":"B108","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1007\/s00122-011-1691-8","article-title":"Effect of population size and unbalanced data sets on QTL detection using genome-wide association mapping in barley breeding germplasm","volume":"124","author":"Wang","year":"2012","journal-title":"Theor. Appl. Genet."},{"key":"B109","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1104\/pp.108.126375","article-title":"Transcriptome analyses show changes in gene expression to accompany pollen germination and tube growth in Arabidopsis","volume":"148","author":"Wang","year":"2008","journal-title":"Plant Physiol."},{"key":"B110","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1111\/pbi.12371","article-title":"A SNP-based consensus genetic map for synteny-based trait targeting in faba bean (Vicia faba L.)","volume":"14","author":"Webb","year":"2016","journal-title":"Plant Biotechnol. J."},{"key":"B111","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1007\/s42994-020-00022-1","article-title":"NERD1 is required for primexine formation and plasma membrane undulation during microsporogenesis in Arabidopsis thaliana","volume":"1","author":"Xu","year":"2020","journal-title":"aBIOTECH"},{"key":"B112","doi-asserted-by":"publisher","first-page":"1600","DOI":"10.1093\/pcp\/pcaa083","article-title":"De novo shoot regeneration controlled by HEN1 and TCP3\/4 in arabidopsis","volume":"61","author":"Yang","year":"2020","journal-title":"Plant Cell Physiol."},{"key":"B113","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1111\/nph.18188","article-title":"Microtubule-associated IQD9 orchestrates cellulose patterning in seed mucilage","volume":"235","author":"Yang","year":"2022","journal-title":"New Phytol."},{"key":"B114","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1073\/pnas.1114673109","article-title":"Mutations in the GW-repeat protein SUO reveal a developmental function for microRNA-mediated translational repression in Arabidopsis","volume":"109","author":"Yang","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1007934","article-title":"A genome-wide association study reveals a novel regulator of ovule number and fertility in Arabidopsis thaliana","volume":"15","author":"Yuan","year":"2019","journal-title":"PLoS Genet."},{"key":"B116","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1007\/s13593-016-0365-y","article-title":"Grain legume decline and potential recovery in European agriculture: a review","volume":"36","author":"Zander","year":"2016","journal-title":"Agron. Sust. Developm."},{"key":"B117","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1111\/j.1439-0523.2008.01584.x","article-title":"Simple sequence repeats (SSRs) in faba bean: new loci from Orobanche -resistant cultivar \u2018Giza 402.\u2019","volume":"128","author":"Zeid","year":"2009","journal-title":"Plant Breed."},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2156-12-97","article-title":"Generalized linear mixed model for segregation distortion analysis","volume":"12","author":"Zhan","year":"2011","journal-title":"BMC Genet."},{"key":"B119","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1038\/s41588-018-0319-1","article-title":"The genetic basis of inbreeding depression in potato","volume":"51","author":"Zhang","year":"2019","journal-title":"Nat. Genet."},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2023.1201103","article-title":"Construction of a high-density genetic map for faba bean (Vicia faba L.) and quantitative trait loci mapping of seed-related traits","volume":"14","author":"Zhao","year":"2023","journal-title":"Front. Plant Sci."},{"key":"B121","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1104\/pp.20.00014","article-title":"ATP-binding cassette\u00a0G transporters SGE1 and MtABCG13 control stigma exsertion","volume":"184","author":"Zhu","year":"2020","journal-title":"Plant Physiol."},{"key":"B122","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1038\/s41437-019-0238-7","article-title":"Effect of marker segregation distortion on high density linkage map construction and QTL mapping in Soybean (Glycine max L.)","volume":"123","author":"Zuo","year":"2019","journal-title":"Heredity"}],"container-title":["Frontiers in Plant Science"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpls.2025.1457812\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T05:14:20Z","timestamp":1744002860000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpls.2025.1457812\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,7]]},"references-count":122,"alternative-id":["10.3389\/fpls.2025.1457812"],"URL":"https:\/\/doi.org\/10.3389\/fpls.2025.1457812","relation":{},"ISSN":["1664-462X"],"issn-type":[{"value":"1664-462X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,7]]},"article-number":"1457812"}}