{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:52:20Z","timestamp":1787496740942,"version":"build-2736575974"},"reference-count":75,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:00:00Z","timestamp":1761696000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","award":["745012"],"award-info":[{"award-number":["745012"]}],"id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Plant Sci."],"abstract":"<jats:p>\n                    Stresses caused by drought and heavy metals (HMs) adversely affect the establishment and yield potential of\n                    <jats:italic>Miscanthus<\/jats:italic>\n                    plants. These stresses are particularly acute on lower quality \u2018contaminated and marginal-lands\u2019 less suitable for food production. In our prior research assessing drought and zinc stress tolerance across seven novel\n                    <jats:italic>Miscanthus<\/jats:italic>\n                    hybrids, a\n                    <jats:italic>M. sacchariflorus<\/jats:italic>\n                    \u00d7\n                    <jats:italic>M. sinensis<\/jats:italic>\n                    hybrid \u2018GRC10\u2019 exhibited superior stress tolerance and biomass production. This study investigated the effects of drought (D), zinc (Zn) stress, and their combination (D + Zn) on stress tolerance in the\n                    <jats:italic>Miscanthus<\/jats:italic>\n                    GRC10 using untargeted metabolomics to uncover stress tolerance mechanisms. Synchronous measurements of growth parameters, leaf gas exchange parameters, the maximum quantum yield of photosystem II (Fv\/Fm), performance index (PI-ABS), antioxidant enzyme activity, proline, and malondialdehyde (MDA) production were made to elucidate associations. Both D, Zn, and combination (D + Zn) stress induced a broad metabolic reprogramming of secondary metabolism and hormone synthesis pathways. Fatty acid derivatives, nitrogen-containing compounds, hormone\/signal-related compounds (jasmonate), and secondary metabolites (phenylpropanoids, N-containing compounds, and terpenes) showed significant (\n                    <jats:italic>p<\/jats:italic>\n                    &amp;lt; 0.05) abundance changes in response to D, Zn, and its combination D + Zn stress. Drought, Zn, and combination D + Zn stress treatments increased proline accumulation (\n                    <jats:italic>p<\/jats:italic>\n                    &amp;lt; 0.0001), antioxidant enzyme activities (\n                    <jats:italic>p<\/jats:italic>\n                    &amp;lt; 0.05), including superoxide dismutase (SOD), ascorbate peroxidase (APX), glutathione reductase (GR), and decreased levels of MDA. Overall, these responses indicate that the\n                    <jats:italic>Miscanthus<\/jats:italic>\n                    GRC10 hybrid displays a complex response to drought and Zn stresses that confers growth resilience in Zn-contaminated and drought-prone lands.\n                  <\/jats:p>","DOI":"10.3389\/fpls.2025.1556144","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T17:50:10Z","timestamp":1761760210000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Integrative physiological, biochemical, and metabolomic analyses reveal complex drought and zinc stress tolerance in a novel Miscanthus hybrid"],"prefix":"10.3389","volume":"16","author":[{"given":"Monirul","family":"Islam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amjad","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leilei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Ferrarini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Lucini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Clifton-Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Amaducci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,10,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2642","DOI":"10.3390\/molecules28062642","article-title":"Antioxidant activity and photosynthesis efficiency in melissa officinalis subjected to heavy metals stress","volume":"28","author":"Adamczyk-Szabela","year":"2023","journal-title":"Molecules"},{"key":"B2","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1007\/s11816-014-0321-8","article-title":"Exogenous jasmonic acid modulates the physiology, antioxidant defense and glyoxalase systems in imparting drought stress tolerance in different Brassica species","volume":"8","author":"Alam","year":"2014","journal-title":"Plant Biotechnol. 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