{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T17:58:12Z","timestamp":1784224692347,"version":"3.55.0"},"reference-count":68,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82204561"],"award-info":[{"award-number":["82204561"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Plant Sci."],"abstract":"<jats:p>Secondary metabolites in hemp enhance its pharmaceutical and nutraceutical value, yet the epigenetic regulatory network underlying secondary metabolite biosynthesis remains poorly understood in hemp. Here, we profiled the inflorescences of two cultivars with different trichome density by integrating metabolomics, transcriptomics and ATAC-seq. Multi-omics data revealed pronounced differences in metabolites (491 differentially accumulated metabolites (DAMs)), transcripts (8343 differentially expressed genes (DEGs)), and chromatin accessibility (11376 different accessibility genes, (DAGs)) between two cultivars. Integrated analyses reveal that increased chromatin accessibility at the promoters of several flavonoid-biosynthetic genes up-regulated their expression, resulting in the accumulation of flavonoids. Although chromatin accessibility of cannabinoid biosynthetic gene promoters modulates content, differential chromatin accessibility of the promoter of fatty acid biosynthetic and trichome density (trichome initiation, MeJA signaling, and identity of floral organ) related genes constitutes the key driver underlying cannabinoid divergence between two cultivars. Our study advances the understanding of epigenetic regulation of plant secondary metabolites and offers a novel strategy for enhancing cannabinoid and flavonoid content in Cannabis, providing efficient and precise molecular markers for the selection and breeding of new cannabis varieties.<\/jats:p>","DOI":"10.3389\/fpls.2025.1687700","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T06:31:55Z","timestamp":1768804315000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Chromatin accessibility directly governs flavonoid biosynthesis and indirectly orchestrates cannabinoid production in Cannabis"],"prefix":"10.3389","volume":"16","author":[{"given":"Yuanchang","family":"Ma","sequence":"first","affiliation":[{"name":"Key Laboratory of Specialty Agri-product Quality and Hazard Controlling Technology of Zhejiang Province, College of Life Sciences, China Jiliang University","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuye","family":"Wei","sequence":"additional","affiliation":[{"name":"Key Laboratory of Beijing for Identification and Safety Evaluation of Chinese Medicine, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences","place":["Beijing, China"]},{"name":"School of Pharmacy, Chengdu University of Traditional Chinese Medicine","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weixin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Key Laboratory of Specialty Agri-product Quality and Hazard Controlling Technology of Zhejiang Province, College of Life Sciences, China Jiliang University","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An","family":"Xie","sequence":"additional","affiliation":[{"name":"Key Laboratory of Specialty Agri-product Quality and Hazard Controlling Technology of Zhejiang Province, College of Life Sciences, China Jiliang University","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongzhong","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Specialty Agri-product Quality and Hazard Controlling Technology of Zhejiang Province, College of Life Sciences, China Jiliang University","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Specialty Agri-product Quality and Hazard Controlling Technology of Zhejiang Province, College of Life Sciences, China Jiliang University","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingcheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Specialty Agri-product Quality and Hazard Controlling Technology of Zhejiang Province, College of Life Sciences, China Jiliang University","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linlin","family":"Dong","sequence":"additional","affiliation":[{"name":"Key Laboratory of Beijing for Identification and Safety Evaluation of Chinese Medicine, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"Ning","sequence":"additional","affiliation":[{"name":"Key Laboratory of Specialty Agri-product Quality and Hazard Controlling Technology of Zhejiang Province, College of Life Sciences, China Jiliang University","place":["Hangzhou, China"]},{"name":"Key Laboratory of Beijing for Identification and Safety Evaluation of Chinese Medicine, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,19]]},"reference":[{"key":"B1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/B978-0-12-802778-3.00007-X","article-title":"Chapter 7 - Hemp Seed (Cannabis sativa L.) Proteins: Composition, Structure, Enzymatic Modification, and Functional or Bioactive Properties","volume-title":"Sustainable Protein Sources","author":"Aluko","year":"2017"},{"key":"B2","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.ceb.2016.01.013","article-title":"Chromosome condensation and decondensation during mitosis","volume":"40","author":"Antonin","year":"2016","journal-title":"Curr. Opin. Cell Biol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1006\/anbo.1999.0937","article-title":"Glandular trichomes on the leaves and flowers of plectranthus ornatus: morphology, distribution and histochemistry","volume":"84","author":"Ascens\u00c3O","year":"1999","journal-title":"Ann. Bot."},{"key":"B4","doi-asserted-by":"publisher","first-page":"e70141","DOI":"10.1111\/tpj.70141","article-title":"Time-course transcriptome and chromatin accessibility analyses reveal the dynamic transcriptional regulation shaping spikelet hull size","volume":"122","author":"Chen","year":"2025","journal-title":"Plant J."},{"key":"B5","doi-asserted-by":"publisher","first-page":"13626","DOI":"10.3390\/ijms140713626","article-title":"Early phenylpropanoid biosynthetic steps in Cannabis sativa: link between genes and metabolites","volume":"14","author":"Docimo","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"B6","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1111\/tpj.16769","article-title":"A FLOWERING LOCUS T ortholog is associated with photoperiod-insensitive flowering in hemp (Cannabis sativa L.)","volume":"119","author":"Dowling","year":"2024","journal-title":"Plant J."},{"key":"B7","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1515\/dmdi.1995.12.3-4.189","article-title":"Diversity and evolution of plant P450 and P450-reductases","volume":"12","author":"Durst","year":"1995","journal-title":"Drug Metabol Drug Interact."},{"key":"B8","doi-asserted-by":"publisher","first-page":"9384","DOI":"10.1073\/pnas.93.18.9384","article-title":"Chromatin structure and gene expression","volume":"93","author":"Felsenfeld","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2018640118","article-title":"Reduction in gene expression noise by targeted increase in accessibility at gene loci","volume":"118","author":"Fraser","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B10","doi-asserted-by":"publisher","first-page":"2930","DOI":"10.3390\/foods10122930","article-title":"Structural and physicochemical characteristics of oil bodies from hemp seeds (Cannabis sativa L.)","volume":"10","author":"Garcia","year":"2021","journal-title":"Foods"},{"key":"B11","doi-asserted-by":"publisher","first-page":"31","DOI":"10.3390\/medicines6010031","article-title":"Cannabis and its secondary metabolites: their use as therapeutic drugs, toxicological aspects, and analytical determination","volume":"6","author":"Gon\u00e7alves","year":"2019","journal-title":"Medicines (Bsl)"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2023.1142913","article-title":"Transcriptomic, metabolomic, and ATAC-seq analysis reveal the regulatory mechanism of senescence of post-harvest tomato fruit","volume":"14","author":"Guo","year":"2023","journal-title":"Front. Plant Sci."},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbi.2024.102549","article-title":"Building a biofactory: Constructing glandular trichomes in Cannabis sativa","volume":"80","author":"Hancock","year":"2024","journal-title":"Curr. Opin. Plant Biol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1016\/j.molp.2021.06.028","article-title":"Plant cytochrome P450 plasticity and evolution","volume":"14","author":"Hansen","year":"2021","journal-title":"Mol. Plant"},{"key":"B15","doi-asserted-by":"publisher","first-page":"3646","DOI":"10.3390\/plants12203646","article-title":"Morphological characterization of cannabis sativa L. Throughout its complete life cycle","volume":"12","author":"Hesami","year":"2023","journal-title":"Plants (Bsl)"},{"key":"B16","doi-asserted-by":"publisher","first-page":"3309","DOI":"10.1038\/s41598-020-60172-6","article-title":"Secondary metabolites profiled in cannabis inflorescences, leaves, stem barks, and roots for medicinal purposes","volume":"10","author":"Jin","year":"2020","journal-title":"Sci. Rep."},{"key":"B17","first-page":"151","article-title":"Chapter Six - Function and Evolution of Plant Cytochrome P450","volume-title":"Recent Advances in Phytochemistry","author":"Kahn","year":"2000"},{"key":"B18","doi-asserted-by":"publisher","first-page":"R118","DOI":"10.1186\/gb-2006-7-12-r118","article-title":"Dynamic usage of transcription start sites within core promoters","volume":"7","author":"Kawaji","year":"2006","journal-title":"Genome Biol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"e1008633","DOI":"10.1371\/journal.ppat.1008633","article-title":"Dynamic chromatin accessibility profiling reveals changes in host genome organization in response to baculovirus infection","volume":"16","author":"Kong","year":"2020","journal-title":"PloS Pathog."},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2023.117772","article-title":"The morphology, inflorescence yield, and secondary metabolite accumulation in hemp type Cannabis sativa can be influenced by the R:FR ratio or the amount of short wavelength radiation in a spectrum","volume":"208","author":"Kotiranta","year":"2024","journal-title":"Ind. Crops Prod"},{"key":"B21","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1101\/gr.242594.118","article-title":"A physical and genetic map of Cannabis sativa identifies extensive rearrangements at the THC\/CBD acid synthase loci","volume":"29","author":"Laverty","year":"2019","journal-title":"Genome Res."},{"key":"B22","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/s13059-019-1642-2","article-title":"Identification of transcription factor binding sites using ATAC-seq","volume":"20","author":"Li","year":"2019","journal-title":"Genome Biol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"2772","DOI":"10.1093\/plphys\/kiae273","article-title":"Transcriptional landscape and dynamics involved in sugar and acid accumulation during apple fruit development","volume":"195","author":"Li","year":"2024","journal-title":"Plant Physiol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"12824","DOI":"10.3390\/ijms222312824","article-title":"The flavonoid biosynthesis network in plants","volume":"22","author":"Liu","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B25","doi-asserted-by":"publisher","first-page":"15004","DOI":"10.3390\/ijms241915004","article-title":"An investigation of the JAZ family and the cwMYC2-like protein to reveal their regulation roles in the meJA-induced biosynthesis of \u03b2-elemene in curcuma wenyujin","volume":"24","author":"Liu","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"B26","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/s11103-021-01129-9","article-title":"Three novel transcription factors involved in cannabinoid biosynthesis in Cannabis sativa L","volume":"106","author":"Liu","year":"2021","journal-title":"Plant Mol. Biol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"B28","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1111\/tpj.14516","article-title":"Cannabis glandular trichomes alter morphology and metabolite content during flower maturation","volume":"101","author":"Livingston","year":"2020","journal-title":"Plant J."},{"key":"B29","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1104\/pp.010907","article-title":"Plant two-component signaling systems and the role of response regulators","volume":"128","author":"Lohrmann","year":"2002","journal-title":"Plant Physiol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.48130\/VR-2022-0005","article-title":"The regulation of nutrient and flavor metabolism in tomato fruit","volume":"2","author":"Lu","year":"2022","journal-title":"Veg Res."},{"key":"B31","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1038\/s41586-019-0978-9","article-title":"Complete biosynthesis of cannabinoids and their unnatural analogues in yeast","volume":"567","author":"Luo","year":"2019","journal-title":"Nature"},{"key":"B32","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1104\/pp.108.125385","article-title":"Functional specialization of the TRANSPARENT TESTA GLABRA1 network allows differential hormonal control of laminal and marginal trichome initiation in Arabidopsis rosette leaves","volume":"148","author":"Maes","year":"2008","journal-title":"Plant Physiol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1300\/J237v09n01_04","article-title":"Accumulation of cannabinoids in glandular trichomes of cannabis (Cannabaceae)","volume":"9","author":"Mahlberg","year":"2004","journal-title":"J. Ind. Hmp"},{"key":"B34","doi-asserted-by":"publisher","first-page":"2881","DOI":"10.1021\/jo01284a051","article-title":"Novel condensation products of diketene","volume":"32","author":"Marcus","year":"1967","journal-title":"J. Org Chem."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1093\/jxb\/erv534","article-title":"Flowering and trichome development share hormonal and transcription factor regulation","volume":"67","author":"Mat\u00edas-Hern\u00e1ndez","year":"2016","journal-title":"J. Exp. Bot."},{"key":"B36","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1016\/j.molcel.2019.12.021","article-title":"Chromosome conformation capture and beyond: toward an integrative view of chromosome structure and function","volume":"77","author":"McCord","year":"2020","journal-title":"Mol. Cell"},{"key":"B37","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1007\/s00425-007-0668-y","article-title":"Physiological roles of plant glycoside hydrolases","volume":"227","author":"Minic","year":"2008","journal-title":"Planta"},{"key":"B38","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1038\/ng1180","article-title":"PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes","volume":"34","author":"Mootha","year":"2003","journal-title":"Nat. Genet."},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.3390\/plants10040706","article-title":"Genome-wide mapping of histone H3 lysine 4 trimethylation (H3K4me3) and its involvement in fatty acid biosynthesis in sunflower developing seeds","volume":"10","author":"Moreno-P\u00e9rez","year":"2021","journal-title":"Plants"},{"key":"B40","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.indcrop.2019.02.016","article-title":"LED lighting affects the composition and biological activity of Cannabis sativa secondary metabolites","volume":"132","author":"Namdar","year":"2019","journal-title":"Ind. Crops Prod"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.3390\/horticulturae10121269","article-title":"Transcriptomic and metabolomic analysis reveals improved fruit quality in grafted watermelon","volume":"10","author":"Ning","year":"2024","journal-title":"Horticulturae"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2022.904163","article-title":"Metabolomics analysis revealed the characteristic metabolites of hemp seeds varieties and metabolites responsible for antioxidant properties","volume":"13","author":"Ning","year":"2022","journal-title":"Front. Plant Sci."},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2021.775019","article-title":"Genomic and transcriptomic analysis provide insights into root rot resistance in panax notoginseng","volume":"12","author":"Ning","year":"2021","journal-title":"Front. Plant Sci."},{"key":"B44","doi-asserted-by":"publisher","first-page":"6008","DOI":"10.1002\/jsfa.13429","article-title":"Selective penetration of fullerenol through pea seed coats mitigates osmosis-repressed germination via chromatin remodeling and transcriptional reprograming","volume":"104","author":"Ning","year":"2024","journal-title":"J. Sci. Food Agric."},{"key":"B45","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1046\/j.0960-7412.2001.01214.x","article-title":"Entopically additive expression of GLABRA2 alters the frequency and spacing of trichome initiation","volume":"29","author":"Ohashi","year":"2002","journal-title":"Plant J."},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.3389\/fagro.2025.1539426","article-title":"Agronomic evaluation of hemp (Cannabis sativa L.) for cannabidiol production in Yunnan, China","volume":"7","author":"Ouyang","year":"2025","journal-title":"Front. Agron."},{"key":"B47","doi-asserted-by":"publisher","first-page":"5619","DOI":"10.3390\/ijms24065619","article-title":"Integrated ATAC-seq and RNA-seq data analysis to reveal osbZIP14 function in rice in response to heat stress","volume":"24","author":"Qiu","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"B48","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.1101\/gad.8.12.1388","article-title":"The GLABRA2 gene encodes a homeo domain protein required for normal trichome development in Arabidopsis","volume":"8","author":"Rerie","year":"1994","journal-title":"Genes Dev."},{"key":"B49","doi-asserted-by":"publisher","first-page":"3709","DOI":"10.1111\/febs.12363","article-title":"Medicago truncatula histidine-containing phosphotransfer protein: structural and biochemical insights into the cytokinin transduction pathway in plants","volume":"280","author":"Ruszkowski","year":"2013","journal-title":"FEBS J."},{"key":"B50","doi-asserted-by":"publisher","first-page":"e201301011","DOI":"10.5936\/csbj.201301011","article-title":"Integrated LC-MS\/MS system for plant metabolomics","volume":"4","author":"Sawada","year":"2013","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"B51","doi-asserted-by":"publisher","first-page":"e0133292","DOI":"10.1371\/journal.pone.0133292","article-title":"The genetic structure of marijuana and hemp","volume":"10","author":"Sawler","year":"2015","journal-title":"PloS One"},{"key":"B52","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1038\/s41576-019-0128-0","article-title":"Long-range enhancer-promoter contacts in gene expression control","volume":"20","author":"Schoenfelder","year":"2019","journal-title":"Nat. Rev. Genet."},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1093\/nargab\/lqab101","article-title":"PEPATAC: an optimized pipeline for ATAC-seq data analysis with serial alignments","volume":"3","author":"Smith","year":"2021","journal-title":"NAR Genom Bioinform."},{"key":"B54","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/s13072-019-0260-2","article-title":"Combined analysis of dissimilar promoter accessibility and gene expression profiles identifies tissue-specific genes and actively repressed networks","volume":"12","author":"Starks","year":"2019","journal-title":"Epigenet. Chromatin"},{"key":"B55","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1111\/j.1365-313X.2012.04949.x","article-title":"The hexanoyl-CoA precursor for cannabinoid biosynthesis is formed by an acyl-activating enzyme in Cannabis sativa trichomes","volume":"71","author":"Stout","year":"2012","journal-title":"Plant J."},{"key":"B56","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1046\/j.1432-1327.1999.00509.x","article-title":"Structural maintenance of chromosomes (SMC) proteins: conserved molecular properties for multiple biological functions","volume":"263","author":"Strunnikov","year":"1999","journal-title":"Eur. J. Biochem."},{"key":"B57","doi-asserted-by":"publisher","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B58","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1111\/plb.13223","article-title":"The gene NtMYC2a acts as a 'master switch' in the regulation of JA-induced nicotine accumulation in tobacco","volume":"23","author":"Sui","year":"2021","journal-title":"Plant Biol. (Stuttg)"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1016\/j.atech.2022.100111","article-title":"Characterization of trichome phenotypes to assess maturation and flower development in Cannabis sativa L. (cannabis) by automatic trichome gland analysis","volume":"3","author":"Sutton","year":"2023","journal-title":"Smt Agric. Technol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"355","DOI":"10.3390\/microorganisms8030355","article-title":"Cannabis microbiome and the role of endophytes in modulating the production of secondary metabolites: an overview","volume":"8","author":"Taghinasab","year":"2020","journal-title":"Microorganisms"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2021.721986","article-title":"Cannabis glandular trichomes: A cellular metabolite factory","volume":"12","author":"Tanney","year":"2021","journal-title":"Front. Plant Sci."},{"key":"B62","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1111\/j.1469-8137.2009.03067.x","article-title":"Distinct relationships between GLABRA2 and single-repeat R3 MYB transcription factors in the regulation of trichome and root hair patterning in Arabidopsis","volume":"185","author":"Wang","year":"2010","journal-title":"New Phytol."},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1186\/s12870-021-02840-x","article-title":"Analysis and review of trichomes in plants","volume":"21","author":"Wang","year":"2021","journal-title":"BMC Plant Biol."},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1093\/hr\/uhad150","article-title":"Cannabis sativa: origin and history, glandular trichome development, and cannabinoid biosynthesis","volume":"10","author":"Xie","year":"2023","journal-title":"Hortic. Res."},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1016\/j.xplc.2023.100666","article-title":"3D genome structural variations play important roles in regulating seed oil content of Brassica napus","volume":"5","author":"Zhang","year":"2024","journal-title":"Plant Commun."},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2025.121380","article-title":"Integrated transcriptome and chromatin accessibility dynamics in developing walnut kernels reveal regulators of oil accumulation","volume":"233","author":"Zhang","year":"2025","journal-title":"Ind. Crops Prod"},{"key":"B67","doi-asserted-by":"publisher","first-page":"e70073","DOI":"10.1111\/tpj.70073","article-title":"The chromatin accessibility landscape during early maize seed development","volume":"121","author":"Zheng","year":"2025","journal-title":"Plant J."},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1016\/j.plaphy.2025.110242","article-title":"miRNA rco-MIR395a-p5_1ss8TC suppresses CsOMT957 expression leading to reduction in cannflavin A accumulation in Cannabis sativa L","volume":"228","author":"Zhou","year":"2025","journal-title":"Plant Physiol. Biochem."}],"container-title":["Frontiers in Plant Science"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpls.2025.1687700\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T06:31:59Z","timestamp":1768804319000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpls.2025.1687700\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,19]]},"references-count":68,"alternative-id":["10.3389\/fpls.2025.1687700"],"URL":"https:\/\/doi.org\/10.3389\/fpls.2025.1687700","relation":{},"ISSN":["1664-462X"],"issn-type":[{"value":"1664-462X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,19]]},"article-number":"1687700"}}