{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T07:10:32Z","timestamp":1772521832959,"version":"3.50.1"},"reference-count":37,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:00:00Z","timestamp":1772496000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010203","name":"Agriculture Research System of China","doi-asserted-by":"publisher","award":["CARS-21"],"award-info":[{"award-number":["CARS-21"]}],"id":[{"id":"10.13039\/501100010203","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Plant Sci."],"abstract":"<jats:p>\n                    The depletion of wild\n                    <jats:italic>Glycyrrhiza<\/jats:italic>\n                    resources has made artificial cultivation essential; however, soil salinization severely limits the yield and quality of\n                    <jats:italic>G. uralensis<\/jats:italic>\n                    . Zinc oxide nanoparticles (ZnO NPs) exhibit promising potential in phytoremediation, yet their regulatory mechanisms under salt stress remain unclear. In this study,\n                    <jats:italic>Glycyrrhiza uralensis<\/jats:italic>\n                    was used to investigate the effects of salt stress and the modulating effects of ZnO NPs. Our results showed that ZnO NPs application enhanced salt accumulation in\n                    <jats:italic>Glycyrrhiza uralensis<\/jats:italic>\n                    while maintaining photosynthetic performance and root growth. Integrated transcriptomic and metabolomic analyses revealed that salt stress disrupted phenylpropanoid and flavonoid biosynthesis pathways, leading to detectable alterations in root metabolic profiles. Moreover, ZnO NPs modulated root metabolite accumulation and related gene expression, which further affected root metabolites and activated plant defense systems, contributing to enhanced root system adaptation and overall plant resilience under salt stress. These findings suggest that ZnO NPs treatment is associated with improved salt stress performance in\n                    <jats:italic>G. uralensis<\/jats:italic>\n                    under the present experimental conditions. This study provides insights into the potential application of ZnO nanoparticles in improving salt tolerance, thereby offering a promising strategy for the sustainable cultivation of\n                    <jats:italic>Glycyrrhiza uralensis<\/jats:italic>\n                    in saline-alkali soils.\n                  <\/jats:p>","DOI":"10.3389\/fpls.2026.1767899","type":"journal-article","created":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T06:49:25Z","timestamp":1772520565000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrated transcriptomic and metabolomic analysis reveals zinc oxide nanoparticles associated modulation of salt stress responses in Glycyrrhiza uralensis"],"prefix":"10.3389","volume":"17","author":[{"given":"Shangtao","family":"Wang","sequence":"first","affiliation":[{"name":"School of Chinese Materia Medica, Beijing University of Chinese Medicine","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang","family":"Liang","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica, Beijing University of Chinese Medicine","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shurui","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica, Beijing University of Chinese Medicine","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siyu","family":"Ma","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica, Beijing University of Chinese Medicine","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaping","family":"Li","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica, Beijing University of Chinese Medicine","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yifan","family":"Yan","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica, Beijing University of Chinese Medicine","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gonghao","family":"Xu","sequence":"additional","affiliation":[{"name":"Luxi-ratio Ltd.","place":["Taipei, Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenghao","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica, Beijing University of Chinese Medicine","place":["Beijing, China"]},{"name":"Guangxi Institute of Botany, Chinese Academy of Sciences","place":["Guilin, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhirong","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica, Beijing University of Chinese Medicine","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2022.932861","article-title":"Zinc oxide nanoparticles improved chlorophyll contents, physical parameters, and wheat yield under salt stress","volume":"13","author":"Adil","year":"2022","journal-title":"Front. 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