{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T23:14:30Z","timestamp":1792624470149,"version":"4.5.0"},"reference-count":69,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:00:00Z","timestamp":1772755200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Plant Sci."],"abstract":"<jats:p>\n                    Diabetes mellitus is a chronic metabolic disorder that affects millions of people globally. Among three types of diabetes, Type 2 diabetes mellitus (T2DM) is a rapidly growing global health challenge. Despite available modern antidiabetic drugs, patients still struggle with side effects and treatment failure, as an alternative to this, there is a crucial requirement to develop a potential and traditional plant-based medicine which could be a safer sources and multi-target therapies to treat chronic disease like diabetes.\n                    <jats:italic>Solanum lasiocarpum<\/jats:italic>\n                    (\n                    <jats:italic>S. lasiocarpum<\/jats:italic>\n                    ) is a sour fruit-vegetable being widely used in Southeast Asia as both food and traditional medicine, including for the management of diabetes. However, its active components and antidiabetic mechanisms have not been systematically explored. In this study, we combined metabolomics, proteomics, and transcriptomics to investigate the bioactive pathways and potential molecular targets of\n                    <jats:italic>S. lasiocarpum<\/jats:italic>\n                    . Untargeted UHPLC\u2013QTOF\u2013MS profiling identified 45 candidate bioactive compounds with good predicted gastrointestinal absorption, and the network pharmacology analysis linked these compounds to 43 diabetes-related human targets. Protein\u2013protein interaction analysis highlighted several core nodes, including\n                    <jats:italic>TNF<\/jats:italic>\n                    ,\n                    <jats:italic>PPARG<\/jats:italic>\n                    ,\n                    <jats:italic>IL6<\/jats:italic>\n                    ,\n                    <jats:italic>AKT1<\/jats:italic>\n                    , and\n                    <jats:italic>STAT3<\/jats:italic>\n                    , and functional enrichment suggested roles in hormone regulation, inflammation, glucose and lipid metabolism, and vascular function.\n                    <jats:italic>De novo<\/jats:italic>\n                    transcriptome assembly and data-independent acquisition-based proteomics of mature\n                    <jats:italic>S. lasiocarpum<\/jats:italic>\n                    fruit showed that central carbon metabolism is highly active and that the shikimate, phenylpropanoid, and flavonoid pathways are strongly expressed at both gene and protein levels. Key enzymes such as\n                    <jats:italic>EPSPS<\/jats:italic>\n                    ,\n                    <jats:italic>PAL<\/jats:italic>\n                    ,\n                    <jats:italic>C4H<\/jats:italic>\n                    ,\n                    <jats:italic>4CL<\/jats:italic>\n                    ,\n                    <jats:italic>CHS<\/jats:italic>\n                    ,\n                    <jats:italic>CHI<\/jats:italic>\n                    ,\n                    <jats:italic>F3H<\/jats:italic>\n                    , and\n                    <jats:italic>FLS<\/jats:italic>\n                    formed a coherent biosynthetic network supporting sustained production of phenolic and flavonoid metabolites. Integrating these omics layers with target prediction suggests that\n                    <jats:italic>S. lasiocarpum<\/jats:italic>\n                    may exert antidiabetic effects by modulating a\n                    <jats:italic>TNF\u2013PPARG<\/jats:italic>\n                    axis, reducing pro-inflammatory signaling while supporting insulin-sensitizing pathways. Overall, these results support the traditional use of\n                    <jats:italic>S. lasiocarpum<\/jats:italic>\n                    and provide a multi-omics resource to prioritise candidate metabolites, enzymes and targets for follow-up studies. As the pathway links were inferred computationally, the proposed\n                    <jats:italic>TNF\u2013PPARG<\/jats:italic>\n                    -centred mechanism should be regarded as hypothesis-generating and will require validation in experimental models and, ultimately, well-designed human intervention trials.\n                  <\/jats:p>","DOI":"10.3389\/fpls.2026.1774981","type":"journal-article","created":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T06:40:35Z","timestamp":1772779235000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Integrated metabolomic, proteomic, and transcriptomic analyses reveal the production of bioactive metabolites and antidiabetic effects in mature Solanum lasiocarpum fruit"],"prefix":"10.3389","volume":"17","author":[{"given":"Fangbo","family":"Li","sequence":"first","affiliation":[{"name":"Faculty of Health and Life Sciences, INTI International University","place":["Nilai, Negeri Sembilan, Malaysia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixiao","family":"Jiang","sequence":"additional","affiliation":[{"name":"Faculty of Health and Life Sciences, INTI International University","place":["Nilai, Negeri Sembilan, Malaysia"]},{"name":"Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine; 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