{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T08:10:31Z","timestamp":1792138231765,"version":"4.4.0"},"reference-count":52,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Plant Sci."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Pine wilt disease caused by\n                      <jats:italic>Bursaphelenchus xylophilus<\/jats:italic>\n                      constitutes a severe threat to global pine forests. The UDP-glycosyltransferase (\n                      <jats:italic>UGT<\/jats:italic>\n                      ) gene family is involved in xenobiotic detoxification, environmental adaptation, and other biological processes, but systematic identification of this family in\n                      <jats:italic>B. xylophilus<\/jats:italic>\n                      has not yet been performed. This study aimed to comprehensively identify\n                      <jats:italic>UGT<\/jats:italic>\n                      family members in\n                      <jats:italic>B. xylophilus<\/jats:italic>\n                      and clarify their molecular roles in xenobiotic detoxification and host adaptation regulation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Based on genome-wide data, we identified 47\n                      <jats:italic>UGT<\/jats:italic>\n                      genes in\n                      <jats:italic>B. xylophilus<\/jats:italic>\n                      and systematically analyzed their phylogenetic relationships, physicochemical properties, gene structures, transcription factor binding sites, as well as expression profiles under nematicide stress and during the infection stage.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The results showed that the\n                      <jats:italic>UGT<\/jats:italic>\n                      genes are distributed across 5 chromosomes. Compared with those of\n                      <jats:italic>Caenorhabditis elegans<\/jats:italic>\n                      , these genes exhibit both conserved and species-specific evolutionary patterns, and no gene duplication events were detected in the\n                      <jats:italic>UGT<\/jats:italic>\n                      genes. Expression profile analysis revealed that members of this gene family are involved in the stress response of\n                      <jats:italic>B. xylophilus<\/jats:italic>\n                      to nematicide exposure; most\n                      <jats:italic>UGT<\/jats:italic>\n                      genes were significantly upregulated during the infection stage, and several genes maintained high expression levels, suggesting that they may play key roles in xenobiotic detoxification and host adaptation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>\n                      This study clarifies the functional importance of the\n                      <jats:italic>UGT<\/jats:italic>\n                      gene family in\n                      <jats:italic>B. xylophilus<\/jats:italic>\n                      , providing a theoretical basis for elucidating its adaptive mechanisms and developing control strategies.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpls.2026.1786843","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T06:06:40Z","timestamp":1775801200000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Genome-wide characterization of the Bursaphelenchus xylophilus UGT gene family and its potential roles in detoxification and host interaction"],"prefix":"10.3389","volume":"17","author":[{"given":"Xiong","family":"Xiong","sequence":"first","affiliation":[{"name":"College of Forestry, Shandong Agricultural University","place":["Tai\u2019an, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Li","sequence":"additional","affiliation":[{"name":"College of Plant Protection, Shandong Agricultural University","place":["Tai\u2019an, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuaibin","family":"Sun","sequence":"additional","affiliation":[{"name":"College of Plant Protection, Shandong Agricultural University","place":["Tai\u2019an, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunyang","family":"Ju","sequence":"additional","affiliation":[{"name":"College of Plant Protection, Shandong Agricultural University","place":["Tai\u2019an, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengming","family":"Yu","sequence":"additional","affiliation":[{"name":"College of Plant Protection, Shandong Agricultural University","place":["Tai\u2019an, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yehan","family":"Tian","sequence":"additional","affiliation":[{"name":"College of Plant Protection, Shandong Agricultural University","place":["Tai\u2019an, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhua","family":"Xu","sequence":"additional","affiliation":[{"name":"Weihai Wendeng District Forestry Development Center","place":["Weihai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gengwu","family":"Sun","sequence":"additional","affiliation":[{"name":"Weihai Wendeng District Forestry Development Center","place":["Weihai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanrong","family":"Li","sequence":"additional","affiliation":[{"name":"College of Forestry, Shandong Agricultural University","place":["Tai\u2019an, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huixiang","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Plant Protection, Shandong Agricultural University","place":["Tai\u2019an, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1038\/s41586-024-07487-w","article-title":"Accurate structure prediction of biomolecular interactions with AlphaFold 3","volume":"630","author":"Abramson","year":"2024","journal-title":"Nature"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.748290","article-title":"Editorial: Invertebrate UDP-glycosyltransferases: Nomenclature, diversity and functions","volume":"12","author":"Ahn","year":"2021","journal-title":"Front. 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