{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T14:08:38Z","timestamp":1780063718477,"version":"3.54.0"},"reference-count":138,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Plant Sci."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Multiple-stress is defined as the simultaneous or sequential exposure of plants to multiple abiotic constraints, which triggers regulatory programs that differ fundamentally from single-stress responses. In potato (\n                      <jats:italic>Solanum tuberosum<\/jats:italic>\n                      L.), drought, salinity, heat, and cold severely impair tuber development, yet the molecular architecture underlying resilience to combined stress remains unclear. We hypothesized that multi-stress conditions activate an integrated regulatory network linking tuber induction with stress-responsive metabolic and redox pathways.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>RNA-seq profiling of microtuberization under combined osmotic, salinity, heat, and cold stress was performed. Differential expression analysis identified shared differentially expressed genes (DEGs). A subset of upregulated genes was used for protein\u2013protein interaction (PPI) network construction. Comparative regulatory analyses were performed, and selected genes were validated by qPCR. Statistical analyses were conducted to assess differential expression and network enrichment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 2,046 shared DEGs were identified, including 1,212 upregulated and 834 downregulated genes. A PPI network constructed from 1,475 unique upregulated genes revealed 317 highly interconnected components. Network analysis identified the StSP6A\u2013FD tuberigen complex as a central regulatory hub integrating developmental signaling with phenylpropanoid metabolism, oxylipin biosynthesis, and redox regulation. Multiple components were associated with hydrogen sulfide (H\u2082S) signaling, suggesting redox\u2013gasotransmitter integration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Comparative regulatory analysis revealed conservation of the ERF\u2013NAC\u2013MYB\u2013bZIP transcription factor framework, along with expansion of stress-responsive modules. Collectively, these findings establish a mechanistic framework linking tuber induction with adaptive metabolic remodeling under multi-stress conditions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpls.2026.1828205","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T13:32:39Z","timestamp":1780061559000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Molecular resilience: genetic analysis of multiple-stress tolerance (osmotic, salinity, cold and heat) during potato (Solanum tuberosum L.) microtuberization"],"prefix":"10.3389","volume":"17","author":[{"given":"Lisset","family":"Herrera-Isidron","sequence":"first","affiliation":[{"name":"Unidad Profesional Interdisciplinaria de Ingenier\u00eda Campus Guanajuato (UPIIG), Instituto Polit\u00e9cnico Nacional","place":["Silao de la Victoria, Guanajuato, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilse Araceli","family":"Careaga-Rojas","sequence":"additional","affiliation":[{"name":"Unidad Profesional Interdisciplinaria de Ingenier\u00eda Campus Guanajuato (UPIIG), Instituto Polit\u00e9cnico Nacional","place":["Silao de la Victoria, Guanajuato, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Braulio","family":"Uribe-Lopez","sequence":"additional","affiliation":[{"name":"Departamento de Biotecnologia y Bioquimica, Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional (IPN)","place":["Irapuato, Guanajuato, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea-Maria","family":"Navarro-Vega","sequence":"additional","affiliation":[{"name":"Unidad Profesional Interdisciplinaria de Ingenier\u00eda Campus Guanajuato (UPIIG), Instituto Polit\u00e9cnico Nacional","place":["Silao de la Victoria, Guanajuato, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Barraza","sequence":"additional","affiliation":[{"name":"Laboratorio Biotechnolgika","place":["La Paz, Baja California Sur, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliana","family":"Valencia-Lozano","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigaci\u00f3n Interdisciplinaria (LII), Universidad Nacional Aut\u00f3noma de M\u00e9xico, Escuela Nacional de Estudios Superiores","place":["Le\u00f3n de los Aldama, Guanajuato, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Luis","family":"Cabrera-Ponce","sequence":"additional","affiliation":[{"name":"Laboratorio Nacional PlanTECC, Departamento de Ingenier\u00eda Gen\u00e9tica, Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional (IPN)","place":["Irapuato, Guanajuato, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2200100","DOI":"10.1002\/pmic.202200100","article-title":"Proteomic analysis of the meristematic root zone in contrasting genotypes reveals new insights in drought tolerance in rice","volume":"22","author":"Abdirad","year":"2022","journal-title":"Proteomics"},{"key":"B2","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1007\/978-3-030-66965-2_10","article-title":"Recent advances in potato (Solanum tuberosum L.) breeding","volume":"8","author":"Aksoy","year":"2021","journal-title":"Adv. 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