{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T06:27:31Z","timestamp":1787120851750,"version":"build-2736575974"},"reference-count":58,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100020760","name":"Sanya Yazhou Bay Science and Technology City","doi-asserted-by":"publisher","award":["Grant No: SKJC-JYRC-2025-69"],"award-info":[{"award-number":["Grant No: SKJC-JYRC-2025-69"]}],"id":[{"id":"10.13039\/100020760","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013142","name":"Key Research and Development Project of Hainan Province","doi-asserted-by":"publisher","award":["Grant No. ZDYF2025GXJS137"],"award-info":[{"award-number":["Grant No. ZDYF2025GXJS137"]}],"id":[{"id":"10.13039\/501100013142","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Plant Sci."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Fusarium wilt of banana (FWB), caused by\n                      <jats:italic>Fusarium oxysporum<\/jats:italic>\n                      f. sp.\n                      <jats:italic>cubense<\/jats:italic>\n                      tropical race 4 (Foc TR4), poses a serious threat to the safety and sustainable development of the banana industry. Biological control represents one of the most environmentally friendly approaches for managing this disease.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this study,\n                      <jats:italic>Streptomyces violaceusniger<\/jats:italic>\n                      WZS5\u20136 antifungal activity against Foc TR4 has been investigated through an integrated approach combining antifungal assays, genome analysis, and metabolomic profiling. For the purpose, the effects of the bacterial strain and its cell-free extract on morphological and ultrastructural changes on pathogenic fungal hyphae and spores were assessed using scanning and transmission electron microscopy. LC\u2013MS analysis was used to identify the metabolites responsible for antifungal activity. We further explored the potential of\n                      <jats:italic>S. violaceusniger<\/jats:italic>\n                      WZS5\u20136 against Foc TR4 through\n                      <jats:italic>in planta<\/jats:italic>\n                      validation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Streptomyces violaceusniger<\/jats:italic>\n                      WZS5\u20136 exhibited a strong inhibition rate of 91.57% on Foc TR4. The cell-free extract obtained from\n                      <jats:italic>S. violaceusniger<\/jats:italic>\n                      WZS5\u20136 strongly inhibited Foc TR4 with an EC\n                      <jats:sub>50<\/jats:sub>\n                      value of 91.62 \u00b5g\u00b7mL\n                      <jats:sup>-1<\/jats:sup>\n                      , indicating the presence of antifungal bioactive metabolites. The results showed that\n                      <jats:italic>S. violaceusniger<\/jats:italic>\n                      WZS5\u20136 significantly inhibited the mycelial growth of Foc TR4 and induced alterations in spore morphology, mycelial ultrastructure, and cell membrane leakage. Metabolomic profiling of the\n                      <jats:italic>S. violaceusniger<\/jats:italic>\n                      WZS5\u20136 extracts revealed numerous antifungal metabolites, among which the key metabolites, viz., citronellic acid and furanodienone, exhibited strong inhibitory effects on Foc TR4, with antifungal activity of 61.13% and 57.44%, respectively. Moreover, strain WZS5\u20136 not only demonstrated 61.54% control efficacy against FWB in a pot experiment but also showed promising growth-promoting effects on banana plants.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>\n                      This study demonstrates that\n                      <jats:italic>S. violaceusniger<\/jats:italic>\n                      WZS5\u20136 inhibits Foc TR4 through a multi-level mechanism involving cellular disruption, metabolic adaptation, and activation of host defense responses. These findings highlight the potential of\n                      <jats:italic>S. violaceusniger<\/jats:italic>\n                      WZS5\u20136 as a promising novel candidate strain to be employed as a biological control agent of FWB.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpls.2026.1863092","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T05:46:16Z","timestamp":1787118376000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Streptomyces violaceusniger WZS5\u20136 suppresses Fusarium oxysporum f. sp. cubense tropical race 4 via antifungal metabolites and host defense induction"],"prefix":"10.3389","volume":"17","author":[{"given":"Wenjing","family":"Ge","sequence":"first","affiliation":[{"name":"National Key Laboratory of Tropical Crop Breeding, Institute of Tropical Bioscience and Biotechnology & Sanya Research Institute, Chinese Academy of Tropical Agricultural Sciences (CATAS)","place":["Sanya, Hainan, China"]},{"name":"Sanya Institute of Henan University, Henan University","place":["Sanya, Hainan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Jing","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Tropical Crop Breeding, Institute of Tropical Bioscience and Biotechnology & Sanya Research Institute, Chinese Academy of Tropical Agricultural Sciences (CATAS)","place":["Sanya, Hainan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Zang","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Tropical Crop Breeding, Institute of Tropical Bioscience and Biotechnology & Sanya Research Institute, Chinese Academy of Tropical Agricultural Sciences (CATAS)","place":["Sanya, Hainan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hafiz Faiq","family":"Bakhat","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Tropical Crop Breeding, Institute of Tropical Bioscience and Biotechnology & Sanya Research Institute, Chinese Academy of Tropical Agricultural Sciences (CATAS)","place":["Sanya, Hainan, China"]},{"name":"Department of Environmental Sciences, COMSATS University Islamabad","place":["Vehari, Pakistan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyu","family":"Li","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Tropical Crop Breeding, Institute of Tropical Bioscience and Biotechnology & Sanya Research Institute, Chinese Academy of Tropical Agricultural Sciences (CATAS)","place":["Sanya, Hainan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyong","family":"Zi","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Tropical Crop Breeding, Institute of Tropical Bioscience and Biotechnology & Sanya Research Institute, Chinese Academy of Tropical Agricultural Sciences (CATAS)","place":["Sanya, Hainan, China"]},{"name":"School of Tropical Agriculture and Forestry, Hainan University","place":["Sanya, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheli","family":"Ding","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Tropical Crop Breeding, Institute of Tropical Bioscience and Biotechnology & Sanya Research Institute, Chinese Academy of Tropical Agricultural Sciences (CATAS)","place":["Sanya, Hainan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohmed A. 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