{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T05:24:36Z","timestamp":1786944276638,"version":"build-2736575974"},"reference-count":99,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2020\/07045-3"],"award-info":[{"award-number":["2020\/07045-3"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Plant Sci."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Huanglongbing (HLB) is a devastating disease impacting citrus orchards worldwide. Identifying candidate genes and\/or genomic regions that significantly influence plants' response to HLB is essential for breeding programs. Nevertheless, this remains a challenge, especially during the early stages of the citrus-pathogen interaction, when phenotypically distinguishing tolerant genotypes is not trivial. This work focused on identifying genomic regions and candidate genes associated with citrus response to\n                      <jats:italic>Candidatus<\/jats:italic>\n                      Liberibacter asiaticus (\n                      <jats:italic>C<\/jats:italic>\n                      Las).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Quantitative trait loci (QTL) mapping was performed in a citrandarin population (278 individuals) derived from a fullsib cross between susceptible\n                      <jats:italic>Citrus sunki<\/jats:italic>\n                      (CS) and tolerant\n                      <jats:italic>Poncirus trifoliata<\/jats:italic>\n                      (PT). The mapping population was genotyped using DArTseq markers and the SNPs obtained from them (DArTseq-derived SNPs), as well as the EMBRAPA Multispecies 65K Illumina Infinium\u00ae chip. Phenotyping was based on four individual trials (two in a greenhouse and two in field conditions). QTL mapping was based on composite interval mapping implemented in the fullsibQTL software, with the cycle threshold (Ct) of quantitative PCR (qPCR) as the trait of interest for assessing\n                      <jats:italic>C<\/jats:italic>\n                      Las quantification in infected tissues, which can be evaluated in plants at any developmental stage. The biological function of QTLs was investigated by gene annotation using the chromosome-level phased\n                      <jats:italic>Citrus sinensis<\/jats:italic>\n                      genome (assembly DVS_A1.0) as the reference. The candidate genes were functionally annotated using Blast2Go software.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A predominance of markers in a 1:1 ratio was observed, resulting in two maps, one for each parent. The linkage map had 5464 cM (1872 markers) for CS and 4794 cM (1340 markers) for PT. A total of 44 QTLs were mapped: 25 for the CS map (13 for field and 12 for greenhouse conditions), of which 17 were located at gene sites; and 19 were mapped for the PT (nine for field and 10 for greenhouse conditions), of which 16 were located at gene sites.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Several genes associated with the identified QTLs are involved in stress responses, making them potential targets for further functional validation. These genomic regions and candidate genes provide valuable targets for future incorporation into citrus breeding programs aimed at developing HLB tolerance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpls.2026.1864793","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T04:34:17Z","timestamp":1786941257000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Genetic mapping reveals QTLs associated with HLB response determined by Candidatus Liberibacter asiaticus quantification in a Citrus sunki \u00d7 Poncirus trifoliata segregating population"],"prefix":"10.3389","volume":"17","author":[{"given":"Luciane","family":"Santini-Gazaffi","sequence":"first","affiliation":[{"name":"Instituto Agron\u00f4mico de Campinas, Centro APTA Citros Sylvio Moreira","place":["Sao Paulo, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Gazaffi","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Carlos, Centro de Ci\u00eancias Agr\u00e1rias, Departamento de Biotecnologia e Produ\u00e7\u00e3o Vegetal e Animal","place":["Sao Paulo, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinara Oliveira","family":"de Aquino","sequence":"additional","affiliation":[{"name":"Instituto Agron\u00f4mico de Campinas, Centro APTA Citros Sylvio Moreira","place":["Sao Paulo, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e1rio","family":"Grattapaglia","sequence":"additional","affiliation":[{"name":"Empresa Brasileira de Pesquisa Agropecu\u00e1ria (EMBRAPA) - Recursos Gen\u00e9ticos e Biotecnologia","place":["Bras\u00edlia, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marin\u00eas","family":"Bastianel","sequence":"additional","affiliation":[{"name":"Instituto Agron\u00f4mico de Campinas, Centro APTA Citros Sylvio Moreira","place":["Sao Paulo, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari\u00e2ngela","family":"Cristofani-Yaly","sequence":"additional","affiliation":[{"name":"Instituto Agron\u00f4mico de Campinas, Centro APTA Citros Sylvio Moreira","place":["Sao Paulo, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos Antonio","family":"Machado","sequence":"additional","affiliation":[{"name":"Instituto Agron\u00f4mico de Campinas, Centro APTA Citros Sylvio Moreira","place":["Sao Paulo, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.scienta.2012.08.036","article-title":"Tolerance of trifoliate citrus rootstock hybrids to Candidatus Liberibacter asiaticus","volume":"147","author":"Albrecht","year":"2012","journal-title":"Sci. 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