{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T06:27:33Z","timestamp":1787120853048,"version":"build-2736575974"},"reference-count":129,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Plant Sci."],"abstract":"<jats:p>\n                    Grapevine (\n                    <jats:italic>Vitis<\/jats:italic>\n                    ) is a crop of global importance. Insect pests, such as\n                    <jats:italic>Popillia japonica<\/jats:italic>\n                    (Japanese beetle), threaten yields of this high value crop.\n                    <jats:italic>Vitis labrusca<\/jats:italic>\n                    (accession \u2018GREM4\u2019) exhibits the highly-advantageous trait of resistance to Japanese beetles while\n                    <jats:italic>Vitis vinifera<\/jats:italic>\n                    is susceptible (cultivar \u2018PN40024\u2019). Herein, we undertook an insect herbivory time-course transcriptomic study to identify gene expression differences, and associated processes and pathways, which differ, both temporally and spatially, between \u2018GREM4\u2019 and \u2018PN40024\u2019 under insect herbivory. Upon herbivory, the number of significantly differentially expressed genes (DEGs) increased over time in \u2018GREM4\u2019 but decreased in \u2018PN40024\u2019. \u2018GREM4\u2019 exhibited greater defense gene enrichment after 4h of herbivory compared to 30min, conversely, \u2018PN40024\u2019 exhibited a greater 30min response which diminished by 4h. In systemic leaves, \u2018GREM4\u2019 exhibited 10x more DEGs than \u2018PN40024\u2019. Across herbivory and systemic responses, genes associated with insect herbivory defense, including flavonoids, phenylpropanoids, acyltransferases, and signaling-pathways, were implicated in greater numbers, or exclusively, in \u2018GREM4\u2019 compared to \u2018PN40024\u2019 and likely impact insect resistance. Our findings provide insight into the genetic variation, processes, and pathways which underly insect herbivory resistance in\n                    <jats:italic>Vitis.<\/jats:italic>\n                    We report candidate genes and biological pathways for future functional studies and breeding initiatives to advance cultivar development and yields.\n                  <\/jats:p>","DOI":"10.3389\/fpls.2026.1874271","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T05:45:55Z","timestamp":1787118355000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Insect herbivory time-course reveals unique temporal transcriptomic responses in resistant and susceptible grapevines"],"prefix":"10.3389","volume":"17","author":[{"given":"Cullen W.","family":"Dixon","sequence":"first","affiliation":[{"name":"Department of Horticulture and Crop Science, The Ohio State University","place":["Columbus, OH, United States"]},{"name":"Center for Applied Plant Sciences, The Ohio State University","place":["Columbus, OH, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea R.","family":"Gschwend","sequence":"additional","affiliation":[{"name":"Department of Horticulture and Crop Science, The Ohio State University","place":["Columbus, OH, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"D7","DOI":"10.1093\/nar\/gkv1290","article-title":"Database resources of the national center for biotechnology information","volume":"44","author":"Agarwala","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2014.00565","article-title":"Transcriptional responses of Arabidopsis thaliana to chewing and sucking insect herbivores","volume":"5","author":"Appel","year":"2014","journal-title":"Front. 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