{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T05:28:18Z","timestamp":1786512498438,"version":"build-2736575974"},"reference-count":73,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Plant Sci."],"abstract":"<jats:p>\n                    Oat (\n                    <jats:italic>Avena sativa<\/jats:italic>\n                    L.) is an important dual-purpose crop used for both food and feed; however, drought stress severely restricts its growth and productivity. Growth-regulating factors (\n                    <jats:italic>GRFs<\/jats:italic>\n                    ) are key regulators of plant growth and development and are also involved in plant responses to abiotic stresses. Nevertheless, the\n                    <jats:italic>GRF<\/jats:italic>\n                    gene family in oat and its potential role in drought tolerance remain largely unclear. In this study, the\n                    <jats:italic>GRF<\/jats:italic>\n                    gene family in oat was systematically identified and characterized using bioinformatics analyses, including phylogenetic analysis, conserved motif analysis, and cis-acting element analysis. The expression patterns of oat\n                    <jats:italic>GRF<\/jats:italic>\n                    genes under drought, cold, salt, and abscisic acid (ABA) treatments were examined. Among the identified genes,\n                    <jats:italic>AsGRF17<\/jats:italic>\n                    was selected for further functional characterization. The\n                    <jats:italic>AsGRF17<\/jats:italic>\n                    gene was cloned, and its subcellular localization was analyzed. In addition, transgenic tobacco plants overexpressing\n                    <jats:italic>AsGRF17<\/jats:italic>\n                    were generated to evaluate its function in drought tolerance using molecular biology, genetic, and physiological approaches. A total of 21\n                    <jats:italic>GRF<\/jats:italic>\n                    family members were identified in the oat genome. Expression profiling showed that most AsGRF genes were upregulated in response to abiotic stresses, including drought, cold, and salt, as well as ABA treatment, whereas a small number of genes were downregulated. Among these members,\n                    <jats:italic>AsGRF17<\/jats:italic>\n                    exhibited the most pronounced transcriptional response in both aboveground and underground tissues. Subcellular localization analysis revealed that\n                    <jats:italic>AsGRF17<\/jats:italic>\n                    is localized in the nucleus. Functional characterization further demonstrated that transgenic tobacco plants overexpressing\n                    <jats:italic>AsGRF17<\/jats:italic>\n                    displayed significantly enhanced drought tolerance compared with wild-type plants. Under drought stress, the transgenic plants showed increased antioxidant enzyme activities, reduced membrane lipid damage, and elevated soluble sugar content, indicating improved antioxidant capacity and osmotic adjustment ability. These findings suggest that\n                    <jats:italic>AsGRF17<\/jats:italic>\n                    positively regulates plant drought tolerance, likely by enhancing antioxidant defense systems and osmotic adjustment capacity. This study provides new insights into the molecular mechanisms underlying\n                    <jats:italic>AsGRF17<\/jats:italic>\n                    -mediated drought tolerance in oat and offers a theoretical basis for the genetic improvement and breeding of drought-resistant oat cultivars.\n                  <\/jats:p>","DOI":"10.3389\/fpls.2026.1885755","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T04:43:50Z","timestamp":1786509830000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Genome-wide identification and characterization of the growth-regulating factor gene family in oat (Avena sativa L.) and functional analysis of AsGRF17 under drought stress"],"prefix":"10.3389","volume":"17","author":[{"given":"Jingya","family":"Li","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology, Northeast Agricultural University","place":["Harbin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilun","family":"Tong","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Northeast Agricultural University","place":["Harbin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaijun","family":"Li","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Northeast Agricultural University","place":["Harbin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiwen","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Northeast Agricultural University","place":["Harbin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Yin","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Northeast Agricultural University","place":["Harbin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Northeast Agricultural University","place":["Harbin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youxu","family":"Jiang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Northeast Agricultural University","place":["Harbin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshui","family":"Zheng","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Northeast Agricultural University","place":["Harbin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Li","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Northeast Agricultural University","place":["Harbin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lulu","family":"He","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Northeast Agricultural University","place":["Harbin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/360438","article-title":"Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal","volume":"2014","author":"Ayala","year":"2014","journal-title":"Oxid. 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