{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T06:27:43Z","timestamp":1786429663573,"version":"build-2736575974"},"reference-count":62,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002332","name":"Semmelweis Egyetem","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002332","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011019","name":"Nemzeti Kutat\u00e1si Fejleszt\u00e9si \u00e9s Innov\u00e1ci\u00f3s Hivatal","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011019","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Plant Sci."],"abstract":"<jats:p>\n                    There is a growing demand for effective, environmentally friendly pesticides due to increasing environmental awareness and stricter regulations on chemical use. Natural products, including secondary metabolites of the invasive tree of heaven (\n                    <jats:italic>Ailanthus altissima<\/jats:italic>\n                    ), could represent promising sources for biopesticide development. A bioassay-guided isolation workflow involving thin-layer chromatography (TLC)\u2013\n                    <jats:italic>Bacillus subtilis<\/jats:italic>\n                    bioassay, TLC\u2013high-resolution mass spectrometry (HRMS), and preparative flash column chromatography yielded three antimicrobial\n                    <jats:italic>seco<\/jats:italic>\n                    -dammarane triterpenes from the methanolic extract of\n                    <jats:italic>A. altissima<\/jats:italic>\n                    petioles, namely the known shoreic acid (\n                    <jats:bold>1<\/jats:bold>\n                    ), and the previously undescribed foveolin C (\n                    <jats:bold>2<\/jats:bold>\n                    ), and (20\n                    <jats:italic>S<\/jats:italic>\n                    ,24\n                    <jats:italic>R<\/jats:italic>\n                    )-epoxy-25-hydroxy-A-homo-4-oxadammaran-3-one (\n                    <jats:bold>3<\/jats:bold>\n                    ). Their structures were elucidated by nuclear magnetic resonance (NMR) spectroscopy, supported by high-resolution tandem mass spectrometry (HRMS\/MS) and polarimetry. The presence of the hydroxylated, polyunsaturated fatty acids 13-hydroxy-9,11-octadecadienoic acid (13-HODE,\n                    <jats:bold>4<\/jats:bold>\n                    ) and 9-hydroxy-10,12-octadecadienoic acid (9-HODE,\n                    <jats:bold>5<\/jats:bold>\n                    ), previously isolated from\n                    <jats:italic>A. altissima<\/jats:italic>\n                    bark, was also confirmed in the petioles by high-performance liquid chromatography (HPLC)\u2013HRMS\/MS. To the best of our knowledge, compounds\n                    <jats:bold>2<\/jats:bold>\n                    and\n                    <jats:bold>3<\/jats:bold>\n                    are reported here as new natural products, while compounds\n                    <jats:bold>1<\/jats:bold>\n                    ,\n                    <jats:bold>4<\/jats:bold>\n                    , and\n                    <jats:bold>5<\/jats:bold>\n                    were detected in\n                    <jats:italic>A. altissima<\/jats:italic>\n                    petioles for the first time. In microdilution assays, compounds\n                    <jats:bold>1<\/jats:bold>\n                    \u2013\n                    <jats:bold>5<\/jats:bold>\n                    showed antimicrobial activity against\n                    <jats:italic>B. subtilis<\/jats:italic>\n                    , the plant pathogenic bacteria\n                    <jats:italic>Curtobacterium flaccumfaciens<\/jats:italic>\n                    pv.\n                    <jats:italic>flaccumfaciens<\/jats:italic>\n                    ,\n                    <jats:italic>Clavibacter michiganensis<\/jats:italic>\n                    , and\n                    <jats:italic>Rhodococcus fascians<\/jats:italic>\n                    , as well as the plant pathogenic fungus\n                    <jats:italic>Fusarium graminearum<\/jats:italic>\n                    . Compound\n                    <jats:bold>1<\/jats:bold>\n                    exhibited the strongest antibacterial activity, especially against\n                    <jats:italic>C. michiganensis<\/jats:italic>\n                    and\n                    <jats:italic>R. fascians<\/jats:italic>\n                    , with minimal inhibitory concentration (MIC) values two-fold lower than those of the positive control neomycin. Compounds\n                    <jats:bold>2<\/jats:bold>\n                    \u2013\n                    <jats:bold>5<\/jats:bold>\n                    were the most effective against\n                    <jats:italic>R. fascians<\/jats:italic>\n                    , with MIC values the same as or two-fold higher than those of neomycin. These results indicate that\n                    <jats:italic>A. altissima<\/jats:italic>\n                    petioles represent a promising source of antimicrobial phytochemicals. After proper structure optimization, they could serve as lead compounds for the development of novel antimicrobial agents against certain phytopathogens.\n                  <\/jats:p>","DOI":"10.3389\/fpls.2026.1888371","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T05:34:52Z","timestamp":1786426492000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Novel seco-dammarane triterpenes with antimicrobial activity against plant pathogens from Ailanthus altissima petioles"],"prefix":"10.3389","volume":"17","author":[{"given":"Anna","family":"Csel\u0151tey","sequence":"first","affiliation":[{"name":"Plant Protection Institute, HUN-REN Centre for Agricultural Research","place":["Budapest, Hungary"]},{"name":"Doctoral School, Semmelweis University","place":["Budapest, Hungary"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rton","family":"Baglyas","sequence":"additional","affiliation":[{"name":"Plant Protection Institute, HUN-REN Centre for Agricultural Research","place":["Budapest, Hungary"]},{"name":"Doctoral School, Semmelweis University","place":["Budapest, Hungary"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panna","family":"Aschenbrenner","sequence":"additional","affiliation":[{"name":"Plant Protection Institute, HUN-REN Centre for Agricultural Research","place":["Budapest, Hungary"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zolt\u00e1n","family":"Bozs\u00f3","sequence":"additional","affiliation":[{"name":"Plant Protection Institute, HUN-REN Centre for Agricultural Research","place":["Budapest, Hungary"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ildik\u00f3","family":"Schwarczinger","sequence":"additional","affiliation":[{"name":"Plant Protection Institute, HUN-REN Centre for Agricultural Research","place":["Budapest, Hungary"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f3zsef","family":"Bakonyi","sequence":"additional","affiliation":[{"name":"Plant Protection Institute, HUN-REN Centre for Agricultural Research","place":["Budapest, Hungary"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e1s","family":"Darcsi","sequence":"additional","affiliation":[{"name":"Pharmaceutical Chemistry and Technology Department, National Center for Public Health and Pharmacy","place":["Budapest, Hungary"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vesna","family":"Glavnik","sequence":"additional","affiliation":[{"name":"Laboratory for Food Chemistry, National Institute of Chemistry","place":["Ljubljana, Slovenia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irena","family":"Vovk","sequence":"additional","affiliation":[{"name":"Laboratory for Food Chemistry, National Institute of Chemistry","place":["Ljubljana, Slovenia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1gnes M.","family":"M\u00f3ricz","sequence":"additional","affiliation":[{"name":"Plant Protection Institute, HUN-REN Centre for Agricultural Research","place":["Budapest, Hungary"]},{"name":"Doctoral School, Semmelweis University","place":["Budapest, Hungary"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1088\/1757-899X\/1031\/1\/012087","article-title":"Volatile compounds in flowers, samaras, leaves and stem bark of Ailanthus altissima (Mill.) 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