{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:24:29Z","timestamp":1787063069590,"version":"build-2736575974"},"reference-count":55,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Plant Sci."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Sweet potato weevils (\n                      <jats:italic>Cylas formicarius<\/jats:italic>\n                      ) are devastating pest that seriously affect sweet potato production, and their feeding can significantly reduce sweet potato yield and quality.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      To elucidate the molecular mechanisms underlying sweet potato responses to\n                      <jats:italic>C. formicarius<\/jats:italic>\n                      herbivory, the resistant cultivar J2 and the susceptible cultivar G12 were selected for integrated transcriptomic and metabolomic analyses of leaves and storage roots during the early stage of infestation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The results demonstrated that, in storage roots, the resistant J2 exhibited a greater number of differentially expressed genes (DEGs) and differentially accumulated metabolites (DAMs) than G12; however, in leaves, J2 displayed more DEGs but fewer DAMs than G12, and these were primarily enriched in defense-related pathways, including phenylpropanoid biosynthesis, amino acid biosynthesis, flavonoid biosynthesis, and \u03b1-linolenic acid metabolism. Integrated multi-omics analysis further suggested that phenylpropanoid metabolism and amino acid biosynthesis may represent key regulatory pathways involved in sweet potato responses to\n                      <jats:italic>C. formicarius<\/jats:italic>\n                      herbivory. Weighted gene co-expression network analysis (WGCNA) identified candidate modules and hub genes significantly associated with resistance to\n                      <jats:italic>C. formicarius<\/jats:italic>\n                      , including key phenylpropanoid biosynthesis genes such as\n                      <jats:italic>PAL<\/jats:italic>\n                      ,\n                      <jats:italic>C4H<\/jats:italic>\n                      , and\n                      <jats:italic>PPO<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>\n                      These results suggest that the resistant cultivar J2 enhances is associated with defense against\n                      <jats:italic>C. formicarius<\/jats:italic>\n                      by activating phenylpropanoid and flavonoid metabolism, upregulating JA-associated signaling, and coordinating physical barrier formation with chemical defense accumulation. This study provides a theoretical basis and potential targets for molecular breeding and candidate gene mining in insect-resistant sweet potato.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpls.2026.1901251","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:26:01Z","timestamp":1787059561000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrated transcriptomic and metabolomic analyses of early defense responses in resistant and susceptible sweet potato cultivars under Cylas formicarius herbivory"],"prefix":"10.3389","volume":"17","author":[{"given":"Youmiao","family":"Li","sequence":"first","affiliation":[{"name":"Department of Sweet Potato Genetic Breeding and Application, Institute of Maize Research, Guangxi Academy of Agricultural Sciences","place":["Nanning, China"]},{"name":"College of Agriculture, Guangxi University","place":["Nanning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henan","family":"Ju","sequence":"additional","affiliation":[{"name":"Department of Sweet Potato Genetic Breeding and Application, Institute of Maize Research, Guangxi Academy of Agricultural Sciences","place":["Nanning, China"]},{"name":"College of Agriculture, Guangxi University","place":["Nanning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanqiu","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Sweet Potato Genetic Breeding and Application, Institute of Maize Research, Guangxi Academy of Agricultural Sciences","place":["Nanning, China"]},{"name":"College of Agriculture, Guangxi University","place":["Nanning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huifeng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Sweet Potato Genetic Breeding and Application, Institute of Maize Research, Guangxi Academy of Agricultural Sciences","place":["Nanning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongmei","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Sweet Potato Genetic Breeding and Application, Institute of Maize Research, Guangxi Academy of Agricultural Sciences","place":["Nanning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Sweet Potato Genetic Breeding and Application, Institute of Maize Research, Guangxi Academy of Agricultural Sciences","place":["Nanning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenwei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Sweet Potato Genetic Breeding and Application, Institute of Maize Research, Guangxi Academy of Agricultural Sciences","place":["Nanning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xialin","family":"Zheng","sequence":"additional","affiliation":[{"name":"College of Agriculture, Guangxi University","place":["Nanning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinfeng","family":"Hua","sequence":"additional","affiliation":[{"name":"Department of Sweet Potato Genetic Breeding and Application, Institute of Maize Research, Guangxi Academy of Agricultural Sciences","place":["Nanning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1093\/hr\/uhae014","article-title":"A comprehensive overview of omics-based approaches to enhance biotic and abiotic stress tolerance in sweet potato","volume":"11","author":"Ahmed","year":"2024","journal-title":"Hortic. 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