{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T05:52:51Z","timestamp":1785909171134,"version":"3.56.0"},"reference-count":43,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Plant Sci."],"abstract":"<jats:p>\n                    Transcriptional reprogramming is a critical process in plant immune responses, in which Calmodulin-Binding Protein 60b (CBP60b), a plant-specific atypical transcription factor family, plays an essential role. However, how its transcriptional activity is regulated during immunity remains unclear. Here, we report that 14-3\u20133 proteins, conserved scaffolding proteins in eukaryotes, interact with CBP60b in a calcium-dependent manner and enhance its transcriptional activity on downstream genes. The 14-3\u20133 variant deficient in calcium binding, 14-3-3\u03bb\n                    <jats:sup>G216A<\/jats:sup>\n                    , disrupted the interaction with CBP60b and failed to fully complement the pathogen-sensitive phenotype of the\n                    <jats:italic>14-3-3\u03bb;\u03ba<\/jats:italic>\n                    mutant. Furthermore, we show that the pathogen-induced transcriptional upregulation of\n                    <jats:italic>14-3-3\u03bb<\/jats:italic>\n                    and\n                    <jats:italic>14-3-3\u03ba<\/jats:italic>\n                    is dependent on CBP60b. Finally, genetic evidence demonstrates that 14-3-3s are required for CBP60b function. Collectively, our findings reveal that CBP60b and 14-3\u20133 proteins form an interactome-mediated positive feedback loop to orchestrate immune responses in a calcium-dependent manner.\n                  <\/jats:p>","DOI":"10.3389\/fpls.2026.1916745","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T05:41:52Z","timestamp":1785908512000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The CBP60b-14-3\u20133 functional module regulates immunity in arabidopsis"],"prefix":"10.3389","volume":"17","author":[{"given":"Lu-Shen","family":"Li","sequence":"first","affiliation":[{"name":"College of Agriculture and Biology, Liaocheng University","place":["Liaocheng, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Ma","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Wheat Improvement, College of Life Sciences, Shandong Agricultural University","place":["Tai\u2019an, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Xia","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Wheat Improvement, College of Life Sciences, Shandong Agricultural University","place":["Tai\u2019an, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sha","family":"Li","sequence":"additional","affiliation":[{"name":"Frontiers Science Center for Cell Responses, College of Life Sciences, Nankai University","place":["Tian\u2019jin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.4161\/psb.23182","article-title":"The function of the Mediator complex in plant immunity","volume":"8","author":"An","year":"2013","journal-title":"Plant Signal. 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