{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T13:20:59Z","timestamp":1787664059909,"version":"build-2736575974"},"reference-count":72,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Plant Sci."],"abstract":"<jats:p>\n                    Drought stress severely limits grapevine productivity and compromises fruit quality, with its adverse effects expected to intensify under ongoing climate change. This review synthesizes recent advances in elucidating the molecular and physiological mechanisms underlying drought tolerance in\n                    <jats:italic>Vitis vinifera<\/jats:italic>\n                    . Key physiological responses include abscisic acid (ABA)-mediated amplification of stomatal closure, osmotic adjustment, activation of antioxidant defense systems, and hydraulic vulnerability segmentation-a protective strategy involving the targeted sacrifice of petioles and basal leaves to maintain hydraulic integrity in stems and roots. These coordinated responses are regulated by a complex transcriptional network centered on NAC, WRKY, MYB, and bZIP transcription factors, and further modulated by hormone metabolism, potassium channel activity, aquaporin-facilitated water transport, and both enzymatic and non-enzymatic antioxidant pathways. We also identify critical knowledge gaps requiring urgent attention: (First) field-scale validation of transgenic or CRISPR-edited grapevine lines; (Second) the molecular basis of rootstock\u2013scion signaling during drought stress; and (Third) the integration of multi-omics data with high-resolution phenotyping to accelerate precision breeding. Collectively, this review provides an integrative conceptual framework to support sustainable viticulture in water-limited environments.\n                  <\/jats:p>","DOI":"10.3389\/fpls.2026.1944974","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T12:41:15Z","timestamp":1787661675000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Molecular and physiological mechanisms of drought tolerance in grapevine"],"prefix":"10.3389","volume":"17","author":[{"given":"Yongqiang","family":"Chen","sequence":"first","affiliation":[{"name":"College of Horticulture and Forestry, Tarim University","place":["Alar, China"]},{"name":"National and Local Joint Engineering Laboratory of Efficient and High-Quality Cultivation and Deep Processing Technology of Characteristic Fruit Trees in Southern Xinjiang","place":["Alar, China"]},{"name":"Characteristic Forest and Fruit Technology Innovation Center of Southern Xinjiang in XPCC","place":["Alar, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqin","family":"Tu","sequence":"additional","affiliation":[{"name":"College of Horticulture and Forestry, Tarim University","place":["Alar, China"]},{"name":"Xinjiang Production & Construction Corps Key Laboratory of Protected Agriculture","place":["Alar, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Luo","sequence":"additional","affiliation":[{"name":"College of Horticulture and Forestry, Tarim University","place":["Alar, China"]},{"name":"National and Local Joint Engineering Laboratory of Efficient and High-Quality Cultivation and Deep Processing Technology of Characteristic Fruit Trees in Southern Xinjiang","place":["Alar, China"]},{"name":"Characteristic Forest and Fruit Technology Innovation Center of Southern Xinjiang in XPCC","place":["Alar, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"7286","DOI":"10.1093\/jxb\/eraa392","article-title":"Coordinated decline of leaf hydraulic and stomatal conductances under drought is not linked to leaf xylem embolism for different grapevine cultivars","volume":"71","author":"Albuquerque","year":"2020","journal-title":"J. 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