{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T06:05:35Z","timestamp":1790057135701,"version":"4.0.1"},"reference-count":38,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Plant Sci."],"abstract":"<jats:p>The hollowed root formation and 4\u2032-deoxyflavone accumulation in Scutellaria baicalensis are associated with jasmonate (JAs) signaling, but the upstream regulators integrating these processes with drought tolerance remain unknown. This study investigated whether the 13-lipoxygenase gene SbLOX3 may act as a modulator. Transgenic plants overexpressing SbLOX3 or with RNAi suppression were exposed to polyethylene glycol-simulated and long-term soil drought stress. Metabolite profiling, gene expression analysis, root morphological measurements, and histological observations were conducted. Overexpression of SbLOX3 elevated JAs and 4\u2032-deoxyflavone levels, enhanced root growth and drought tolerance, and induced precocious hollow development in roots under water deficit. In contrast, RNAi lines showed reduced JAs and flavonoid contents, impaired drought tolerance, and absence of hollow formation. SbLOX3 was strongly expressed in xylem, cambium, and phloem under drought. The results suggest that SbLOX3 is associated with a coordinated responseregulate to drought by promoting defensive flavonoid biosynthesis and morphological adaptation, thereby potentially contributing to the accumulation of measured flavonoids.<\/jats:p>","DOI":"10.3389\/fpls.2026.1951407","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T05:40:53Z","timestamp":1790055653000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["SbLOX3 modulates jasmonate-associated flavonoid accumulation, root growth, and drought-induced root hollow formation in Scutellaria baicalensis"],"prefix":"10.3389","volume":"17","author":[{"given":"Dali","family":"Geng","sequence":"first","affiliation":[{"name":"Department of Forestry Engineering, Shandong Agriculture and Engineering University","place":["Jinan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Zhang","sequence":"additional","affiliation":[{"name":"Tea Research Institute, Shandong Academy of Agricultural Sciences","place":["Jinan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saqi","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Forestry Engineering, Shandong Agriculture and Engineering University","place":["Jinan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohan","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Forestry Engineering, Shandong Agriculture and Engineering University","place":["Jinan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Forestry Engineering, Shandong Agriculture and Engineering University","place":["Jinan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojun","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Forestry Engineering, Shandong Agriculture and Engineering University","place":["Jinan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Forestry Engineering, Shandong Agriculture and Engineering University","place":["Jinan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Shu","sequence":"additional","affiliation":[{"name":"Department of Forestry Engineering, Shandong Agriculture and Engineering University","place":["Jinan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"8898","DOI":"10.1111\/pce.70178","article-title":"The transcription factor MYB8 positively regulates flavonoid biosynthesis of Scutellaria baicalensis in response to drought stress","volume":"48","author":"Chen","year":"2025","journal-title":"Plant Cell Environ."},{"key":"B2","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1111\/ppl.12043","article-title":"The role of anthocyanin in photoprotection and its relationship with the xanthophyll cycle and the antioxidant system in apple peel depends on the light conditions","volume":"149","author":"Chen","year":"2013","journal-title":"Physiologia Plantarum"},{"key":"B3","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1093\/jxb\/32.1.93","article-title":"Leaf senescence: correlated with increased levels of membrane permeability and lipid peroxidation, and decreased levels of superoxide dismutase and catalase","volume":"32","author":"Dhindas","year":"1981","journal-title":"J. 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