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Plant Sci."],"abstract":"<jats:p>\n                    Here, we aimed to deepen our understanding of the integration between root and shoot signaling during early nodulation by jointly analyzing proteome-level dynamics in roots and leaves of the wild type (WT) and the hypernodulating autoregulation-of-nodulation (AON) mutant,\n                    <jats:italic>nark<\/jats:italic>\n                    . To this end, we performed a time-course shotgun proteomics experiment in soybean roots and leaves of the same plants inoculated with\n                    <jats:italic>Bradyrhizobium diazoefficiens.<\/jats:italic>\n                    In WT roots, we observed proteome changes linked to calcium-dependent signaling, cellular reorganization, and nutrient allocation. In the leaves, isoflavonoid biosynthesis and immunity-associated responses were differentially regulated in the WT and\n                    <jats:italic>nark<\/jats:italic>\n                    mutant during nodulation. We hypothesize that AON signaling involves a complex interplay between isoflavonoids and immunity, which might be associated with jasmonic acid and\/or systemic auxin transport.\n                  <\/jats:p>","DOI":"10.3389\/fpls.2026.1952260","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T05:32:37Z","timestamp":1789536757000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Systemic proteome remodeling in soybean during early nodulation: distinct responses in roots and leaves"],"prefix":"10.3389","volume":"17","author":[{"given":"Afrodite","family":"Katsaouni","sequence":"first","affiliation":[{"name":"Department of Plant Biotechnology and Bioinformatics, Ghent University","place":["Ghent, Belgium"]},{"name":"VIB Center for Plant Systems Biology, VIB","place":["Ghent, Belgium"]},{"name":"Department of Biomolecular Medicine, Ghent University","place":["Ghent, Belgium"]},{"name":"VIB Center for Medical Biotechnology, VIB","place":["Ghent, Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Guillierme","sequence":"additional","affiliation":[{"name":"Department of Plant Biotechnology and Bioinformatics, Ghent University","place":["Ghent, Belgium"]},{"name":"VIB Center for Plant Systems Biology, VIB","place":["Ghent, Belgium"]},{"name":"Department of Biomolecular Medicine, Ghent University","place":["Ghent, Belgium"]},{"name":"VIB Center for Medical Biotechnology, VIB","place":["Ghent, Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sander E.","family":"Van der Verren","sequence":"additional","affiliation":[{"name":"Department of Plant Biotechnology and Bioinformatics, Ghent University","place":["Ghent, Belgium"]},{"name":"VIB Center for Plant Systems Biology, VIB","place":["Ghent, Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kris","family":"Gevaert","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Medicine, Ghent University","place":["Ghent, Belgium"]},{"name":"VIB Center for Medical Biotechnology, VIB","place":["Ghent, Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofie","family":"Goormachtig","sequence":"additional","affiliation":[{"name":"Department of Plant Biotechnology and Bioinformatics, Ghent University","place":["Ghent, Belgium"]},{"name":"VIB Center for Plant Systems Biology, VIB","place":["Ghent, Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylwia","family":"Struk","sequence":"additional","affiliation":[{"name":"Department of Plant Biotechnology and Bioinformatics, Ghent University","place":["Ghent, Belgium"]},{"name":"VIB Center for Plant Systems Biology, VIB","place":["Ghent, Belgium"]},{"name":"Department of Biomolecular Medicine, Ghent University","place":["Ghent, Belgium"]},{"name":"VIB Center for Medical Biotechnology, VIB","place":["Ghent, Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1023\/A:1013329422954","article-title":"Regulation of nodule formation in soybean-Bradyrhizobium symbiosis is controlled by shoot or\/and root signals","volume":"34","author":"Abd-Alla","year":"2001","journal-title":"Plant Growth Regul."},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1093\/pcp\/pcr165","article-title":"KNApSAcK family databases: integrated metabolite-plant species databases for multifaceted plant research","volume":"53","author":"Afendi","year":"2012","journal-title":"Plant Cell Physiol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s11882-020-00918-4","article-title":"Ligand binding of PR-10 proteins with a particular focus on the Bet v 1 allergen family","volume":"20","author":"Aglas","year":"2020","journal-title":"Curr. 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