{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:56:20Z","timestamp":1790751380515,"version":"4.1.0"},"reference-count":64,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Plant Sci."],"abstract":"<jats:p>\n                    UDP-glycosyltransferases (UGTs) play essential roles in glycosylating plant specialized metabolites, thereby modulating their stability, solubility, and bioactivity to regulate growth, development, and environmental adaptation.\n                    <jats:italic>Dendrobium huoshanense<\/jats:italic>\n                    , a rare and endangered medicinal orchid endemic to China, is renowned for its rich bioactive glycosides, including polysaccharides, flavonoids, and alkaloids, which underpin its high medicinal value. However, systematic genome-wide identification and evolutionary analysis of the\n                    <jats:italic>UGT<\/jats:italic>\n                    gene family in\n                    <jats:italic>Dendrobium<\/jats:italic>\n                    remain limited, hindering their application in stress tolerance and quality improvement. In this study, we performed the first comprehensive genome-wide identification and functional characterization of the UGT family in\n                    <jats:italic>D. huoshanense<\/jats:italic>\n                    by integrating bioinformatics analyses with molecular experiments. A total of 71\n                    <jats:italic>DhUGT<\/jats:italic>\n                    genes were identified and phylogenetically classified into 12 subfamilies. These genes are unevenly distributed across chromosomes, with tandem duplications as the primary driver of family expansion. Cis-regulatory element analysis showed that most\n                    <jats:italic>DhUGT<\/jats:italic>\n                    promoters are enriched with phytohormone- and abiotic stress-responsive motifs. By integrating multi-omics transcriptomic data, we identified\n                    <jats:italic>DhUGT44<\/jats:italic>\n                    (subfamily L) as a high priority candidate, exhibiting consistently high expression across tissues, cultivation conditions, and growth stages. Its promoter contains cold-responsive elements, and RT-qPCR confirmed significant induction under low temperature stress in leaves. Subcellular localization assays demonstrated dual localization of DhUGT44 to the plasma membrane and chloroplasts.\n                    <jats:italic>In vitro<\/jats:italic>\n                    enzymatic assays and transient expression in\n                    <jats:italic>Nicotiana benthamiana<\/jats:italic>\n                    revealed that DhUGT44 specifically catalyzes 7-\n                    <jats:italic>O<\/jats:italic>\n                    -glycosylation of flavonoid substrates. Furthermore, heterologous overexpression of\n                    <jats:italic>DhUGT44<\/jats:italic>\n                    in\n                    <jats:italic>Arabidopsis thaliana<\/jats:italic>\n                    significantly enhanced primary root growth under cold stress compared to wild-type plants, indicating its positive role in cold tolerance. This study provides the first systematic insight into the evolutionary dynamics and transcriptional regulation of the UGT family in\n                    <jats:italic>D. huoshanense<\/jats:italic>\n                    , while elucidating the flavonoid glycosylation function and cold tolerance regulatory role of\n                    <jats:italic>DhUGT44<\/jats:italic>\n                    . These findings offer valuable genetic resources and a theoretical basis for molecular breeding and metabolic engineering of stress tolerance and bioactive compounds in\n                    <jats:italic>Dendrobium<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.3389\/fpls.2026.1959202","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:06:59Z","timestamp":1790748419000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Genome-wide identification of UDP-glycosyltransferase gene family in Dendrobium huoshanense and functional characterization of DhUGT44 mediating flavonoid 7-O-glycosylation and cold tolerance"],"prefix":"10.3389","volume":"17","author":[{"given":"Siyuan","family":"Liu","sequence":"first","affiliation":[{"name":"Traditional Chinese Medicine Institute of Anhui Dabie Mountain, Anhui Engineering Research Center for Eco-Agriculture of Traditional Chinese Medicine, West Anhui University","place":["Lu\u2019an, China"]},{"name":"Department of Pharmacy, Anhui University of Chinese Medicine","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiali","family":"Ren","sequence":"additional","affiliation":[{"name":"Traditional Chinese Medicine Institute of Anhui Dabie Mountain, Anhui Engineering Research Center for Eco-Agriculture of Traditional Chinese Medicine, West Anhui University","place":["Lu\u2019an, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengru","family":"Liu","sequence":"additional","affiliation":[{"name":"Traditional Chinese Medicine Institute of Anhui Dabie Mountain, Anhui Engineering Research Center for Eco-Agriculture of Traditional Chinese Medicine, West Anhui University","place":["Lu\u2019an, China"]},{"name":"Department of Pharmacy, Anhui University of Chinese Medicine","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongfei","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Anhui University of Chinese Medicine","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Xu","sequence":"additional","affiliation":[{"name":"Traditional Chinese Medicine Institute of Anhui Dabie Mountain, Anhui Engineering Research Center for Eco-Agriculture of Traditional Chinese Medicine, West Anhui University","place":["Lu\u2019an, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enhui","family":"Lai","sequence":"additional","affiliation":[{"name":"Traditional Chinese Medicine Institute of Anhui Dabie Mountain, Anhui Engineering Research Center for Eco-Agriculture of Traditional Chinese Medicine, West Anhui University","place":["Lu\u2019an, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanping","family":"Guo","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herb, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bangxing","family":"Han","sequence":"additional","affiliation":[{"name":"Traditional Chinese Medicine Institute of Anhui Dabie Mountain, Anhui Engineering Research Center for Eco-Agriculture of Traditional Chinese Medicine, West Anhui University","place":["Lu\u2019an, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanyong","family":"Yi","sequence":"additional","affiliation":[{"name":"Traditional Chinese Medicine Institute of Anhui Dabie Mountain, Anhui Engineering Research Center for Eco-Agriculture of Traditional Chinese Medicine, West Anhui University","place":["Lu\u2019an, China"]},{"name":"State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herb, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3390\/foods13101467","article-title":"Variations in cold resistance and contents of bioactive compounds among Dendrobium officinale Kimura et Migo strains","volume":"13","author":"Bao","year":"2024","journal-title":"Foods"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1093\/plcell\/koaf087","article-title":"Integrating Arabidopsis and crop species gene discovery for crop improvement","volume":"37","author":"Bevan","year":"2025","journal-title":"Plant Cell"},{"key":"B3","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/j.pbi.2005.03.007","article-title":"Glycosyltransferases: managers of small molecules","volume":"8","author":"Bowles","year":"2005","journal-title":"Curr. 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