{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T01:29:43Z","timestamp":1788658183459,"version":"build-2803163510"},"reference-count":77,"publisher":"Frontiers Media SA","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Front. Psychol."],"DOI":"10.3389\/fpsyg.2015.00147","type":"journal-article","created":{"date-parts":[[2015,3,4]],"date-time":"2015-03-04T10:00:36Z","timestamp":1425463236000},"source":"Crossref","is-referenced-by-count":64,"title":["A brief review of exercise, bipolar disorder, and mechanistic pathways"],"prefix":"10.3389","volume":"6","author":[{"given":"Daniel","family":"Thomson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyna","family":"Turner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue","family":"Lauder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret E.","family":"Gigler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lesley","family":"Berk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajeet B.","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A.","family":"Pasco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Berk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louisa","family":"Sylvia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2015,3,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1037\/a0025877","article-title":"High Behavioral Approach System (BAS) sensitivity, reward responsiveness, and goal-striving predict first onset of bipolar spectrum disorders: a prospective behavioral high-risk design","volume":"121","author":"Alloy","year":"2012","journal-title":"J. Abnorm. Psychol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1007\/s12017-009-8079-9","article-title":"Exercise and bipolar disorder: a review of neurobiological mediators","volume":"11","author":"Alsuwaidan","year":"2009","journal-title":"Neuromolecular Med."},{"key":"B3","doi-asserted-by":"publisher","first-page":"e48814","DOI":"10.1371\/journal.pone.0048814","article-title":"Differential expression of exosomal microRNAs in prefrontal cortices of schizophrenia and bipolar disorder patients","volume":"8","author":"Banigan","year":"2013","journal-title":"PLoS ONE"},{"key":"B4","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1097\/01.HCR.0000300262.69645.95","article-title":"Exercise as a treatment for depression and other psychiatric disorders: a review","volume":"27","author":"Barbour","year":"2007","journal-title":"J. Cardiopulm. Rehabil. Prev."},{"key":"B5","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/j.cmet.2012.01.001","article-title":"Acute exercise remodels promoter methylation in human skeletal muscle","volume":"15","author":"Barres","year":"2012","journal-title":"Cell Metab."},{"key":"B6","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1016\/j.neubiorev.2010.10.001","article-title":"Pathways underlying neuroprogression in bipolar disorder: focus on inflammation, oxidative stress and neurotrophic factors","volume":"35","author":"Berk","year":"2011","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B7","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1186\/1741-7015-11-200","article-title":"So depression is an inflammatory disease, but where does the inflammation come from?","volume":"11","author":"Berk","year":"2013","journal-title":"BMC Med."},{"key":"B8","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1249\/JES.0000000000000025","article-title":"Mitochondrial plasticity with exercise training and extreme environments","volume":"42","author":"Boushel","year":"2014","journal-title":"Exerc. Sport Sci. Rev."},{"key":"B9","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.mhpa.2009.09.003","article-title":"Bipolar disorder and leisure-time physical activity: results from a national survey of Canadians","volume":"2","author":"Cairney","year":"2009","journal-title":"Ment. Health Phys. Act."},{"key":"B10","doi-asserted-by":"publisher","first-page":"15","DOI":"10.2190\/PM.41.1.c","article-title":"Exercise for the treatment of depression and anxiety","volume":"41","author":"Carek","year":"2011","journal-title":"Int. J. Psychiatry Med."},{"key":"B11","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.jpsychires.2014.08.002","article-title":"Adipokines as emerging depression biomarkers: a systematic review and meta-analysis","volume":"59","author":"Carvalho","year":"2014","journal-title":"J. Psychiatr. Res."},{"key":"B12","first-page":"126","article-title":"Physical activity, exercise, and physical fitness: definitions and distinctions for health-related research","volume":"100","author":"Caspersen","year":"1985","journal-title":"Public Health Rep."},{"key":"B13","doi-asserted-by":"publisher","first-page":"2081","DOI":"10.1001\/jama.297.19.2081","article-title":"Effects of different doses of physical activity on cardiorespiratory fitness among sedentary, overweight or obese postmenopausal women with elevated blood pressure: a randomized controlled trial","volume":"297","author":"Church","year":"2007","journal-title":"JAMA"},{"key":"B14","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1161\/01.HYP.0000184225.05629.51","article-title":"Effects of endurance training on blood pressure, blood pressure-regulating mechanisms, and cardiovascular risk factors","volume":"46","author":"Cornelissen","year":"2005","journal-title":"Hypertension"},{"key":"B15","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1016\/j.tins.2007.06.011","article-title":"Exercise builds brain health: key roles of growth factor cascades and inflammation","volume":"30","author":"Cotman","year":"2007","journal-title":"Trends Neurosci."},{"key":"B16","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1001\/jamapsychiatry.2013.1394","article-title":"Comorbidities and mortality in bipolar disorder: a Swedish national cohort study","volume":"70","author":"Crump","year":"2013","journal-title":"JAMA Psychiatry"},{"key":"B17","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1007\/s10880-008-9105-z","article-title":"Exercise and depression: a review of reviews","volume":"15","author":"Daley","year":"2008","journal-title":"J. Clin. Psychol. Med. Settings"},{"key":"B18","doi-asserted-by":"publisher","first-page":"1594","DOI":"10.1056\/NEJMoa1214530","article-title":"A behavioral weight-loss intervention in persons with serious mental illness","volume":"368","author":"Daumit","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"B19","volume-title":"At Least Five a Week: Start Active, Stay Active: A Report on Physical Activity from the Four Home Countries\u2019 Chief Medical Officers","author":"Department of Health.","year":"2011"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1517\/14728222.2014.940893","article-title":"Targeting mitochondrially mediated plasticity to develop improved therapeutics for bipolar disorder","volume":"18","author":"de Sousa","year":"2014","journal-title":"Expert Opin. Ther. Targets"},{"key":"B21","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1016\/j.comppsych.2009.12.001","article-title":"A prospective study of the impact of smoking on outcomes in bipolar and schizoaffective disorder","volume":"51","author":"Dodd","year":"2010","journal-title":"Compr. Psychiatry"},{"key":"B22","doi-asserted-by":"publisher","first-page":"429","DOI":"10.2217\/npy.12.51","article-title":"Effects of smoking on health outcomes in bipolar disorder with a special focus on suicidal behavior","volume":"2","author":"Dome","year":"2012","journal-title":"Neuropsychiatry"},{"key":"B23","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.brainres.2007.12.047","article-title":"Voluntary exercise produces antidepressant and anxiolytic behavioral effects in mice","volume":"1199","author":"Duman","year":"2008","journal-title":"Brain Res."},{"key":"B24","doi-asserted-by":"publisher","first-page":"486","DOI":"10.4088\/JCP.v62n0614","article-title":"Determinants of overweight and obesity in patients with bipolar disorder","volume":"62","author":"Elmslie","year":"2001","journal-title":"J. Clin. Psychiatry"},{"key":"B25","first-page":"84","article-title":"Antidepressant effects of exercise: evidence for an adult-neurogenesis hypothesis?","volume":"31","author":"Ernst","year":"2006","journal-title":"J. Psychiatry Neurosci."},{"key":"B26","volume-title":"Mastering Bipolar Disorder: An Insider\u2019s Guide to Managing Mood Swings and Finding Balance","author":"Eyers","year":"1997"},{"key":"B27","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.psychres.2014.03.009","article-title":"Smartphone data as objective measures of bipolar disorder symptoms","volume":"217","author":"Faurholt-Jepsen","year":"2014","journal-title":"Psychiatry Res."},{"key":"B28","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1038\/mp.2013.172","article-title":"Decreased peripheral brain-derived neurotrophic factor levels are a biomarker of disease activity in major psychiatric disorders: a comparative meta-analysis","volume":"19","author":"Fernandes","year":"2014","journal-title":"Mol. Psychiatry"},{"key":"B29","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1177\/0004867413478217","article-title":"Biomarkers in bipolar disorder: a positional paper from the International Society for Bipolar Disorders Biomarkers Task Force","volume":"47","author":"Frey","year":"2013","journal-title":"Aust. N. Z. J. Psychiatry"},{"key":"B30","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1038\/mp.2011.174","article-title":"Enrichment of cis-regulatory gene expression SNPs and methylation quantitative trait loci among bipolar disorder susceptibility variants","volume":"18","author":"Gamazon","year":"2013","journal-title":"Mol. Psychiatry"},{"key":"B31","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1111\/j.1460-9568.2010.07508.x","article-title":"Exercise impacts brain-derived neurotrophic factor plasticity by engaging mechanisms of epigenetic regulation","volume":"33","author":"Gomez-Pinilla","year":"2011","journal-title":"Eur. J. Neurosci."},{"key":"B32","doi-asserted-by":"publisher","first-page":"S17","DOI":"10.1249\/01.mss.0000321518.49773.7e","article-title":"Hormonal and perceptual changes in bipolar subjects after acute aerobic exercise","volume":"40","author":"Hays","year":"2008","journal-title":"Med. Sci. Sports Exerc."},{"key":"B33","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1038\/jhg.2013.65","article-title":"DNA methylation of the BDNF gene and its relevance to psychiatric disorders","volume":"58","author":"Ikegame","year":"2013","journal-title":"J. Hum. Genet."},{"key":"B34","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1016\/j.jad.2013.09.009","article-title":"Are adults with bipolar disorder active? Objectively measured physical activity and sedentary behavior using accelerometry","volume":"152\u2013154","author":"Janney","year":"2014","journal-title":"J. Affect. Disord."},{"key":"B35","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1097\/SPC.0000000000000014","article-title":"Anti-inflammatory therapy: exploring exercise, serum-derived bovine immunoglobulin\/protein isolates, and ruxolitinib for the cancer-associated weight loss syndrome","volume":"7","author":"Jatoi","year":"2013","journal-title":"Curr. Opin. Support. Palliat. Care"},{"key":"B36","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1016\/j.genhosppsych.2009.07.008","article-title":"Excess heart-disease-related mortality in a national study of patients with mental disorders: identifying modifiable risk factors","volume":"31","author":"Kilbourne","year":"2009","journal-title":"Gen. Hosp. Psychiatry"},{"key":"B37","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1111\/j.1399-5618.2007.00386.x","article-title":"Nutrition and exercise behavior among patients with bipolar disorder","volume":"9","author":"Kilbourne","year":"2007","journal-title":"Bipolar Disord."},{"key":"B38","doi-asserted-by":"publisher","first-page":"277","DOI":"10.2165\/00007256-199621040-00004","article-title":"The effects of acute and chronic exercise on sleep. a meta-analytic review","volume":"21","author":"Kubitz","year":"1996","journal-title":"Sports Med."},{"key":"B39","doi-asserted-by":"publisher","first-page":"107","DOI":"10.3810\/pgm.2010.11.2228","article-title":"Aerobic physical exercise as a possible treatment for neurocognitive dysfunction in bipolar disorder","volume":"122","author":"Kucyi","year":"2010","journal-title":"Postgrad. Med."},{"key":"B40","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1007\/s11011-009-9157-2","article-title":"Exercise increases BDNF levels in the striatum and decreases depressive-like behavior in chronically stressed rats","volume":"24","author":"Marais","year":"2009","journal-title":"Metab. Brain Dis."},{"key":"B41","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1152\/japplphysiol.00979.2010","article-title":"Histone modifications and exercise adaptations","volume":"110","author":"McGee","year":"2011","journal-title":"J. Appl. Physiol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1016\/j.paid.2006.08.024","article-title":"Hypomanic personality features and addictive tendencies","volume":"42","author":"Meyer","year":"2007","journal-title":"Pers. Indiv. Dif."},{"key":"B43","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1177\/0269881105058678","article-title":"Metabolism, lifestyle and bipolar affective disorder","volume":"19","author":"Morriss","year":"2005","journal-title":"J. Psychopharmacol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.neubiorev.2014.05.007","article-title":"Oxidative & nitrosative stress in depression: why so much stress?","volume":"45","author":"Moylan","year":"2014","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B45","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/j.neubiorev.2013.02.003","article-title":"Exercising the worry away: how inflammation, oxidative and nitrogen stress mediates the beneficial effect of physical activity on anxiety disorder symptoms and behaviours","volume":"37","author":"Moylan","year":"2013","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B46","volume-title":"Bipolar Disorder Clinical Guidelines","author":"National Institute for Health","year":"2006"},{"key":"B47","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.jad.2006.11.014","article-title":"The effects of physical activity in the acute treatment of bipolar disorder: a pilot study","volume":"101","author":"Ng","year":"2007","journal-title":"J. Affect. Disord."},{"key":"B48","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1002\/ajmg.b.32163","article-title":"Convergent functional genomics of psychiatric disorders","volume":"162B","author":"Niculescu","year":"2013","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"B49","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1037\/0021-843X.116.1.105","article-title":"A goal-striving life event and the onset of hypomanic and depressive episodes and symptoms: perspective from the behavioral approach system (BAS) dysregulation theory","volume":"116","author":"Nusslock","year":"2007","journal-title":"J. Abnorm. Psychol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/BF00421628","article-title":"Urinary epinephrine and norepinephrine levels in women athletes during training and competition","volume":"36","author":"Pierce","year":"1976","journal-title":"Eur. J. Appl. Physiol. Occup. Physiol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.jad.2010.10.051","article-title":"The precipitants of manic\/hypomanic episodes in the context of bipolar disorder: a review","volume":"133","author":"Proudfoot","year":"2011","journal-title":"J. Affect. Disord."},{"key":"B52","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.jad.2012.05.052","article-title":"Triggers of mania and depression in young adults with bipolar disorder","volume":"143","author":"Proudfoot","year":"2012","journal-title":"J. Affect. Disord."},{"key":"B53","doi-asserted-by":"publisher","first-page":"e132","DOI":"10.1038\/tp.2012.55","article-title":"Epigenetic modifications in frontal cortex from Alzheimer\u2019s disease and bipolar disorder patients","volume":"2","author":"Rao","year":"2012","journal-title":"Transl. Psychiatry"},{"key":"B54","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1097\/01.pra.0000430504.16952.3e","article-title":"Evidence-based recommendations for the prescription of exercise for major depressive disorder","volume":"19","author":"Rethorst","year":"2013","journal-title":"J. Psychiatr. Pract."},{"key":"B55","doi-asserted-by":"publisher","first-page":"491","DOI":"10.2165\/00007256-200939060-00004","article-title":"The antidepressive effects of exercise: a meta-analysis of randomized trials","volume":"39","author":"Rethorst","year":"2009","journal-title":"Sports Med."},{"key":"B56","first-page":"244","article-title":"Hormonal responses of combining endurance-resistance exercise in healthy young men","volume":"54","author":"Rezaee","year":"2014","journal-title":"J. Sports Med. Phys. Fitness"},{"key":"B57","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1176\/ps.2009.60.2.147","article-title":"Premature mortality from general medical illnesses among persons with bipolar disorder: a review","volume":"60","author":"Roshanaei-Moghaddam","year":"2009","journal-title":"Psychiatr. Serv."},{"key":"B58","doi-asserted-by":"publisher","first-page":"3469","DOI":"10.1519\/JSC.0b013e31825bb594","article-title":"Physical exercise as an epigenetic modulator: eustress, the \u201cpositive stress\u201d as an effector of gene expression","volume":"26","author":"Sanchis-Gomar","year":"2012","journal-title":"J. Strength Cond. Res."},{"key":"B59","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.jad.2007.03.002","article-title":"Exercise tolerance is reduced in bipolar illness","volume":"104","author":"Shah","year":"2007","journal-title":"J. Affect. Disord."},{"key":"B60","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1016\/0091-3057(85)90083-8","article-title":"Introduction to symposium on endorphins and behavioural processes; review of literature on endorphins and exercise","volume":"23","author":"Steinberg","year":"1985","journal-title":"Pharmacol. Biochem. Behav."},{"key":"B61","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.jad.2009.11.004","article-title":"What works for people with bipolar disorder? Tips from the experts","volume":"124","author":"Suto","year":"2010","journal-title":"J. Affect. Disord."},{"key":"B62","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1159\/000270916","article-title":"Exercise treatment for bipolar disorder: potential mechanisms of action mediated through increased neurogenesis and decreased allostatic load","volume":"79","author":"Sylvia","year":"2010","journal-title":"Psychother. Psychosom."},{"key":"B63","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1016\/j.jad.2013.07.031","article-title":"Association of exercise with quality of life and mood symptoms in a comparative effectiveness study of bipolar disorder","volume":"151","author":"Sylvia","year":"2013a","journal-title":"J. Affect. Disord."},{"key":"B64","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/2194-7511-1-24","article-title":"Nutrition, Exercise, and Wellness Treatment in bipolar disorder: proof of concept for a consolidated intervention","volume":"1","author":"Sylvia","year":"2013b","journal-title":"Int. J. Bipolar Disord."},{"key":"B65","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1097\/01.pra.0000398419.82362.32","article-title":"Development of an integrated psychosocial treatment to address the medical burden associated with bipolar disorder","volume":"17","author":"Sylvia","year":"2011","journal-title":"J. Psychiatr. Pract."},{"key":"B66","doi-asserted-by":"publisher","first-page":"3109","DOI":"10.1161\/01.CIR.0000075572.40158.77","article-title":"Exercise and physical activity in the prevention and treatment of atherosclerotic cardiovascular disease: a statement from the Council on Clinical Cardiology (Subcommittee on Exercise, Rehabilitation, and Prevention) and the Council on Nutrition, Physical Activity, and Metabolism (Subcommittee on Physical Activity)","volume":"107","author":"Thompson","year":"2003","journal-title":"Circulation"},{"key":"B67","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1016\/j.cpr.2008.04.004","article-title":"Dysregulation of the behavioral approach system (BAS) in bipolar spectrum disorders: review of theory and evidence","volume":"28","author":"Urosevic","year":"2008","journal-title":"Clin. Psychol. Rev."},{"key":"B68","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.jad.2012.07.020","article-title":"A review of physical activity correlates in patients with bipolar disorder","volume":"145","author":"Vancampfort","year":"2013","journal-title":"J. Affect. Disord."},{"key":"B69","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1007\/s10597-009-9272-x","article-title":"A pilot evaluation of the in SHAPE individualized health promotion intervention for adults with mental illness","volume":"46","author":"Van Citters","year":"2010","journal-title":"Community Ment. Health J."},{"key":"B70","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.jad.2009.02.001","article-title":"Lifetime psychiatric disorders and body composition: a population-based study","volume":"118","author":"Williams","year":"2009","journal-title":"J. Affect. Disord."},{"key":"B71","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1123\/jsep.30.4.392","article-title":"The anxiolytic effects of exercise: a meta-analysis of randomized trials and dose-response analysis","volume":"30","author":"Wipfli","year":"2008","journal-title":"J. Sport Exerc. Psychol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/j.cmet.2013.09.008","article-title":"Exercise induces hippocampal BDNF through a PGC-1\u03b1\/FNDC5 pathway","volume":"18","author":"Wrann","year":"2013","journal-title":"Cell Metab."},{"key":"B73","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1016\/j.jad.2011.10.017","article-title":"\u201cIt\u2019s a double edged sword\u201d: a qualitative analysis of the experiences of exercise amongst people with Bipolar Disorder","volume":"136","author":"Wright","year":"2012","journal-title":"J. Affect. Disord."},{"key":"B74","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.mhpa.2009.09.001","article-title":"The effects of physical activity on physical and mental health among individuals with bipolar disorder: a systematic review","volume":"2","author":"Wright","year":"2009","journal-title":"Mental Health Phys. Act."},{"key":"B75","doi-asserted-by":"publisher","first-page":"15810","DOI":"10.1073\/pnas.1415219111","article-title":"Physical exercise-induced hippocampal neurogenesis and antidepressant effects are mediated by the adipocyte hormone adiponectin","volume":"111","author":"Yau","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B76","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1093\/sleep\/20.3.203","article-title":"The effects of acute exercise on sleep: a quantitative synthesis","volume":"20","author":"Youngstedt","year":"1997","journal-title":"Sleep"},{"key":"B77","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.bbr.2005.10.007","article-title":"Beneficial effects of exercise and its molecular mechanisms on depression in rats","volume":"168","author":"Zheng","year":"2006","journal-title":"Behav. Brain Res."}],"container-title":["Frontiers in Psychology"],"original-title":[],"deposited":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T12:52:59Z","timestamp":1566391979000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/Article\/10.3389\/fpsyg.2015.00147\/abstract"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,4]]},"references-count":77,"URL":"https:\/\/doi.org\/10.3389\/fpsyg.2015.00147","relation":{},"ISSN":["1664-1078"],"issn-type":[{"value":"1664-1078","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,4]]}}}