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The present study investigates the effect of positive school environment and agreeableness as protective factors against antisocial behaviors in a sample of undergraduate and graduate students (<jats:italic>n<\/jats:italic> = 304) from northwestern Mexico. Our results demonstrate that a positive school environment has a negative effect on antisocial behaviors via mood and anxiety disorders as well as in interaction with agreeableness, suggesting an interplay between personality and environment. These findings can provide some basis for the development of university programs aimed at fostering positive environments that promote student mental health and protect against antisocial behaviors.<\/jats:p>","DOI":"10.3389\/fpsyg.2021.662146","type":"journal-article","created":{"date-parts":[[2021,7,22]],"date-time":"2021-07-22T10:11:49Z","timestamp":1626948709000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Positive University Environment and Agreeableness as Protective Factors Against Antisocial Behavior in Mexican University Students"],"prefix":"10.3389","volume":"12","author":[{"given":"Martha","family":"Fr\u00edas Armenta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia S.","family":"Corral-Fr\u00edas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,7,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.ijer.2018.01.012","article-title":"The relationships between school climate and adolescent mental health and wellbeing: A systematic literature review.","volume":"88","author":"Aldridge","year":"2018","journal-title":"Int. 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