{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:25:38Z","timestamp":1785198338318,"version":"3.55.0"},"reference-count":84,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T00:00:00Z","timestamp":1641340800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychol."],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The prevalence of anxiety and depression in young students is associated with biosocial factors and scholastic stress. However, few studies have evaluated emotional-affective symptoms that are related to the immune system and antioxidant parameters in young individuals without diagnoses of affective disorders.<\/jats:p><jats:p><jats:bold>Aim:<\/jats:bold> This study aims to assess the relationship between emotional-affective symptoms and glutathione concentrations and CD4 and CD8 lymphocyte counts in college students.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> College students (<jats:italic>n<\/jats:italic> = 177) completed standardized psychometric instruments, including the Perceived Stress Scale, Hamilton Anxiety Scale, Beck Depression Inventory, Familiar Social and Friends Support Scale, and Rosenberg Scale. Blood samples were biochemically analyzed. Analyses of variance were conducted between four groups according to symptom severity.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> A considerable prevalence of stress, anxiety, and depression symptoms was observed and negatively correlated with self-esteem and socio-familiar support. Perceived stress was sexually dimorphic. Although biochemical parameters were within reference ranges, glutathione, CD4, and CD8 tended to be lower in participants with anxiety and depression symptoms, which may be of predictive value.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> The relationship between antioxidant\/immune parameters and socio-affective scores is latent in undiagnosed college students who might develop affective disorders. The findings suggest that during the initial development of affective disorders, stress management strategies should be implemented to help college students cope with the academic load and monitor negative changes in their physiological state.<\/jats:p>","DOI":"10.3389\/fpsyg.2021.666347","type":"journal-article","created":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T06:30:15Z","timestamp":1641364215000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Association Between Socio-Affective Symptoms and Glutathione and CD4 and CD8 Lymphocytes in College Students"],"prefix":"10.3389","volume":"12","author":[{"given":"Cecilia Luz","family":"Balderas-Vazquez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blandina","family":"Bernal-Morales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliud Alfredo","family":"Garcia-Montalvo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Libia","family":"Vega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma Virginia","family":"Herrera-Huerta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Francisco","family":"Rodr\u00edguez-Landa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Felipe","family":"Vel\u00e1zquez-Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda del Carmen","family":"Xotlanihua-Gervacio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga Lidia","family":"Valenzuela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,1,5]]},"reference":[{"key":"B2","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.ajme.2016.01.005","article-title":"Prevalence and associated factors of stress, anxiety and depression among medical Fayoum University students.","volume":"53","author":"Abdel Wahed","year":"2017","journal-title":"Alexandria J. Med."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.3889\/oamjms.2019.319","article-title":"Influence of motivation on academic performance among dental college students.","volume":"7","author":"Almalki","year":"2019","journal-title":"Open Access Maced J. Med. Sci."},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2019.00204","article-title":"The cognitive, behavioral, and emotional aspects of eating habits and association with impulsivity, chronotype, anxiety, and depression: a cross-sectional study.","volume":"13","author":"Aoun","year":"2019","journal-title":"Front. Behav. Neurosci."},{"key":"B5","first-page":"840","article-title":"Frequency and perceived causes of depression, anxiety and stress among medical students of a private medical institute in Karachi: a mixed method study.","volume":"69","author":"Azim","year":"2019","journal-title":"J. Pak. Med. Assoc."},{"key":"B6","doi-asserted-by":"publisher","first-page":"86","DOI":"10.4103\/ipj.ipj_70_18","article-title":"Perceived stress, anxiety, and coping states in medical and engineering students during examinations.","volume":"28","author":"Balaji","year":"2019","journal-title":"Ind. Psychiatry J."},{"key":"B7","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1207\/s15327752jpa6703_13","article-title":"Comparison of beck depression inventories-IA and -II in psychiatric outpatients.","volume":"67","author":"Beck","year":"1996","journal-title":"J. Pers. Assess."},{"key":"B8","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.jadohealth.2018.02.013","article-title":"Suicidal behaviors in college students: frequency, sex differences, and mental health correlates including sluggish cognitive tempo.","volume":"63","author":"Becker","year":"2018","journal-title":"J. Adolesc. Health"},{"key":"B9","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.tine.2019.03.002","article-title":"Principal component regression of academic performance, substance use and sleep quality in relation to risk of anxiety and depression in young adults.","volume":"15","author":"Begdache","year":"2019","journal-title":"Trends Neurosci. Educ."},{"key":"B10","doi-asserted-by":"publisher","first-page":"225","DOI":"10.5772\/60711","article-title":"Impact of anxiety and depression symptoms on scholar performance in high school and university students","author":"Bernal-Morales","year":"2015","journal-title":"A Fresh Look at Anxiety Disorders"},{"key":"B11","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.psyneuen.2014.09.025","article-title":"Is depression associated with increased oxidative stress? A systematic review and meta-analysis.","volume":"51","author":"Black","year":"2015","journal-title":"Psychoneuroendocrinology"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1186\/s13034-018-0245-0","article-title":"Somatic symptoms in adolescence as a predictor of severe mental illness in adulthood: a long-term community-based follow-up study.","volume":"12","author":"Bohman","year":"2018","journal-title":"Child Adolesc. Psychiatry Ment. Health"},{"key":"B13","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1080\/13803395.2019.1611741","article-title":"Anxious, but not depressive, symptoms are associated with poorer prospective memory performance in healthy college students: preliminary evidence using the tripartite model of anxiety and depression.","volume":"41","author":"Bowman","year":"2019","journal-title":"J. Clin. Exp. Neuropsychol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1716","DOI":"10.1002\/1522-2683(200206)23:11<1716::AID-ELPS1716<3.0.CO;2-A","article-title":"Ultrarapid capillary electrophoresis method for the determination of reduced and oxidized glutathione in red blood cells.","volume":"23","author":"Carru","year":"2002","journal-title":"Electrophoresis"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000017518","article-title":"The relationship between levels of self-esteem and the development of depression in young adults with mild depressive symptoms.","volume":"98","author":"Choi","year":"2019","journal-title":"Medicine"},{"key":"B16","doi-asserted-by":"crossref","first-page":"385","DOI":"10.2307\/2136404","article-title":"A global measure of perceived stress.","volume":"24","author":"Cohen","year":"1983","journal-title":"J. Health Soc. Behav."},{"key":"B17","doi-asserted-by":"publisher","first-page":"206","DOI":"10.4067\/S0717-75182015000200014","article-title":"Antioxidants: present perspective for the human health.","volume":"42","author":"Coronado","year":"2015","journal-title":"Rev. Chil. Nutr."},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2018.02287","article-title":"Emotion regulation and the experience of future negative mood: the importance of assessing social support.","volume":"9","author":"d\u2019Arbeloff","year":"2018","journal-title":"Front. Psychol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1111\/nuf.12316","article-title":"Depression, anxiety, and stress among college students in Jordan and their need for mental health services.","volume":"54","author":"Dalky","year":"2018","journal-title":"Nurs. Forum"},{"key":"B20","doi-asserted-by":"publisher","first-page":"717","DOI":"10.14204\/ejrep.34.14034","article-title":"Competency to study and learn in stressful contexts: fundamentals of the e-Coping with Academic Stress\u2122 utility.","volume":"12","author":"De la Fuente","year":"2014","journal-title":"Rev. Electron. Investig. Psicoeduc"},{"key":"B21","first-page":"529","article-title":"Glutathione homeostasis.","volume":"47","author":"Denzoin Vulcano","year":"2013","journal-title":"Acta Bioquim. Clin. Latinoam."},{"key":"B22","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.jalz.2013.01.005","article-title":"Glutathione relates to neuropsychological functioning in mild cognitive impairment.","volume":"10","author":"Duffy","year":"2014","journal-title":"Alzheimers Dement."},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1186\/2049-3258-71-29","article-title":"Socio-demographic correlates of six indicators of alcohol consumption: survey findings of students across seven universities in England, Wales and Northern Ireland.","volume":"71","author":"El Ansari","year":"2013","journal-title":"Arch Public Health"},{"key":"B24","first-page":"179","article-title":"Depression, gender and cellular immunity: influence of gender and severity of depression on the cellular immunity.","volume":"28","author":"Fagniart","year":"2016","journal-title":"Psychiatr. Danub."},{"key":"B25","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.jtumed.2019.08.003","article-title":"Perceived stress and stressors among first-year undergraduate students at a private medical school in Nigeria.","volume":"14","author":"Fasoro","year":"2019","journal-title":"J. Taibah Univ. Med. Sci."},{"key":"B26","doi-asserted-by":"publisher","first-page":"H920","DOI":"10.1152\/ajpheart.00474.2018","article-title":"Sex differences in cerebral autoregulation are unaffected by menstrual cycle phase in young, healthy women.","volume":"316","author":"Favre","year":"2019","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.psychres.2017.05.027","article-title":"Prevalence of psychological stress, depression and anxiety among medical students in Egypt.","volume":"255","author":"Fawzy","year":"2017","journal-title":"Psychiatry Res."},{"key":"B28","first-page":"94","article-title":"Depresi\u00f3n y ansiedad en estudiantes universitarios.","volume":"10","author":"Flores Ocampo","year":"2007","journal-title":"Rev. Electr\u00f3n. Psicol. Iztacala"},{"key":"B29","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.pscychresns.2017.10.001","article-title":"A pilot study of cortical glutathione in youth with depression.","volume":"270","author":"Freed","year":"2017","journal-title":"Psychiatry Res. Neuroimaging"},{"key":"B30","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.bbi.2019.04.041","article-title":"Lifestyle and biological factors influence the relationship between mental health and low-grade inflammation.","volume":"85","author":"Gialluisi","year":"2020","journal-title":"Brain Behav. Immun."},{"key":"B31","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1007\/s00213-014-3687-y","article-title":"Neurochemistry of major depression: a study using magnetic resonance spectroscopy.","volume":"232","author":"Godlewska","year":"2015","journal-title":"Psychopharmacology"},{"key":"B32","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1017\/S1138741600006466","article-title":"Factor structure of the Perceived Stress Scale (PSS) in a sample from Mexico.","volume":"10","author":"Gonz\u00e1lez Ram\u00edrez","year":"2007","journal-title":"Span. J. Psychol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1016\/s2007-4719(14)70387-4","article-title":"Propiedades psicom\u00e9tricas de la Escala de Apoyo Social y Familiar y de Amigos (AFA-R) en una muestra de estudiantes.","volume":"4","author":"Gonz\u00e1lez Ram\u00edrez","year":"2014","journal-title":"Acta Investig. Psicol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"201","DOI":"10.4103\/ipj.ipj_22_18","article-title":"Immunological changes in depression.","volume":"26","author":"Goyal","year":"2017","journal-title":"Ind. Psychiatry J."},{"key":"B35","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.bbi.2015.12.003","article-title":"Deficiencies of the T and natural killer cell system in major depressive disorder: t regulatory cell defects are associated with inflammatory monocyte activation.","volume":"54","author":"Grosse","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"B36","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.pnpbp.2015.11.012","article-title":"Innate and adaptive immunity in the development of depression: an update on current knowledge and technological advances.","volume":"66","author":"Haapakoski","year":"2016","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"B37","first-page":"27","article-title":"Percepci\u00f3n de estr\u00e9s en universitarios, su impacto en el desempe\u00f1o acad\u00e9mico, afrontamiento y apoyo familiar.","volume":"3","author":"Halgravez Perea","year":"2016","journal-title":"Rev. Mex. Estomatol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1111\/j.2044-8341.1959.tb00467.x","article-title":"The assessment of anxiety states by rating.","volume":"32","author":"Hamilton","year":"1959","journal-title":"Br. J. Med. Psychol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"120","DOI":"10.2174\/1570159X11666131120232135","article-title":"Association of oxidative stress to the genesis of anxiety: implications for possible therapeutic interventions.","volume":"12","author":"Hassan","year":"2014","journal-title":"Curr. Neuropharmacol."},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2018.02780","article-title":"Coping with depressive symptoms in young adults: perceived social support protects against depressive symptoms only under moderate levels of stress.","volume":"9","author":"Ioannou","year":"2019","journal-title":"Front. Psychol."},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1186\/s12991-018-0201-7","article-title":"The relation between immunologic variables and symptom factors in patients with major depressive disorder.","volume":"17","author":"Jeon","year":"2018","journal-title":"Ann. Gen. Psychiatry"},{"key":"B42","doi-asserted-by":"publisher","first-page":"149","DOI":"10.4067\/s0717-92272015000300002","article-title":"Academic stress in students from department of health of the University of Los Lagos Osorno.","volume":"53","author":"Jerez-Mendoza","year":"2015","journal-title":"Rev. Chil. Neuro-Psiquiat."},{"key":"B43","doi-asserted-by":"publisher","first-page":"4251","DOI":"10.1177\/0300060519859145","article-title":"Emotional exhaustion, burnout, and perceived stress in dental students.","volume":"47","author":"Jim\u00e9nez-Ortiz","year":"2019","journal-title":"J. Int. Med. Res."},{"key":"B44","first-page":"18","article-title":"Validity of rosenberg\u2019s self-esteem scale on college students from Mexico City.","volume":"5","author":"Jurado C\u00e1rdenas","year":"2015","journal-title":"Latin Am. J. Behav. Med."},{"key":"B45","first-page":"26","article-title":"La estandarizacion del inventario de depresion de Beck para los residentes de la Ciudad de M\u00e9xico.","volume":"21","author":"Jurado","year":"1998","journal-title":"Salud Mental"},{"key":"B46","doi-asserted-by":"publisher","first-page":"799","DOI":"10.4103\/jfmpc.jfmpc_103_18","article-title":"The relationship between gender, age, anxiety, depression, and academic achievement among teenagers.","volume":"8","author":"Khesht-Masjedi","year":"2019","journal-title":"J. Family Med. Prim. Care"},{"key":"B47","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.2147\/NDT.S83577","article-title":"Stress, anxiety, and depression among medical students in a multiethnic setting.","volume":"11","author":"Kulsoom","year":"2015","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.4257","article-title":"Depression, anxiety and stress among final-year medical students.","volume":"11","author":"Kumar","year":"2019","journal-title":"Cureus"},{"key":"B49","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1002\/jclp.22295","article-title":"Depressive symptoms and suicidal ideation in college students: the mediating and moderating roles of hopelessness, alcohol problems, and social support.","volume":"72","author":"Lamis","year":"2016","journal-title":"J. Clin. Psychol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.neulet.2014.03.056","article-title":"In vivo 1H MRS study of potential associations between glutathione, oxidative stress and anhedonia in major depressive disorder.","volume":"569","author":"Lapidus","year":"2014","journal-title":"Neurosci. Lett."},{"key":"B51","doi-asserted-by":"publisher","first-page":"129","DOI":"10.25115\/ejrep.v17i47.2226","article-title":"Stress, self-efficacy, academic achievement and resilience in emerging adults.","volume":"17","author":"Le\u00f3n Hern\u00e1ndez","year":"2019","journal-title":"Rev. Electron. Investig. Psicoeduc."},{"key":"B52","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1016\/j.neubiorev.2011.12.005","article-title":"Mechanistic explanations how cell-mediated immune activation, inflammation and oxidative and nitrosative stress pathways and their sequels and concomitants play a role in the pathophysiology of unipolar depression.","volume":"36","author":"Leonard","year":"2012","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B53","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.psyneuen.2016.11.031","article-title":"Oxidative stress, inflammation and treatment response in major depression.","volume":"76","author":"Lindqvist","year":"2017","journal-title":"Psychoneuroendocrinology"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph16162864","article-title":"Changes in undergraduate students\u2019 psychological well-being as they experience university life.","volume":"16","author":"Liu","year":"2019","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"B55","doi-asserted-by":"publisher","first-page":"8","DOI":"10.22201\/facmed.20075057e.2020.35.20205","article-title":"Academic stress in dental students: association with social support, positive thinking and psychological well-being.","volume":"9","author":"Luna","year":"2020","journal-title":"Investig. Educ. Med."},{"key":"B56","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.biopsych.2019.11.017","article-title":"Peripheral blood cell-stratified subgroups of inflamed depression.","volume":"88","author":"Lynall","year":"2020","journal-title":"Biol. Psychiatry"},{"key":"B57","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1017\/S0029665117002026","article-title":"Nutritional psychiatry: the present state of the evidence.","volume":"76","author":"Marx","year":"2017","journal-title":"Proc. Nutr. Soc."},{"key":"B58","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1016\/j.bbi.2020.07.037","article-title":"Anxiety and depression in COVID-19 survivors: role of inflammatory and clinical predictors.","volume":"89","author":"Mazza","year":"2020","journal-title":"Brain Behav. Immun"},{"key":"B59","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1177\/2470547017692328","article-title":"Neurobiological and systemic effects of chronic stress.","volume":"1","author":"McEwen","year":"2017","journal-title":"Chronic Stress"},{"key":"B60","doi-asserted-by":"publisher","first-page":"454","DOI":"10.20344\/amp.9996","article-title":"Anxiety, depression and academic performance: a study amongst Portuguese medical students versus non-medical students.","volume":"31","author":"Moreira de Sousa","year":"2018","journal-title":"Acta Med. Port."},{"key":"B61","year":"2021","journal-title":"Normal Blood Values."},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-017-1382-3","article-title":"Prevalence and factors associated with depression among medical students in Cameroon: a cross-sectional study.","volume":"17","author":"Ngasa","year":"2017","journal-title":"BMC Psychiatry"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1080\/16549716.2018.1477470","article-title":"How different contexts of social capital are associated with self-rated health among Lithuanian high-school students.","volume":"11","author":"Novak","year":"2018","journal-title":"Glob. Health Action"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/6183757","article-title":"Stress among Portuguese medical students: a national cross-sectional study.","volume":"2020","author":"Oura","year":"2020","journal-title":"J. Environ. Public Health"},{"key":"B65","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.jpsychires.2019.10.012","article-title":"Immune response to stress induction as a predictor of cognitive-behavioral therapy outcomes in adolescent mood disorders: a pilot study.","volume":"120","author":"Pearlstein","year":"2020","journal-title":"J. Psychiatr. Res."},{"key":"B66","doi-asserted-by":"publisher","first-page":"259","DOI":"10.3109\/13651501.2015.1082598","article-title":"Depressive symptoms and social demographic, stress and health risk behaviour among university students in 26 low-, middle- and high-income countries.","volume":"19","author":"Peltzer","year":"2015","journal-title":"Int. J. Psychiatry Clin. Pract."},{"key":"B67","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1111\/jcap.12142","article-title":"Psychophysiological manifestations associated with stress in students of a public university in Mexico.","volume":"29","author":"Pozos-Radillo","year":"2016","journal-title":"J. Child Adolesc. Psychiatr. Nurs."},{"key":"B68","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/BF00898416","article-title":"Measures of perceived social support from friends and from family: three validation studies.","volume":"11","author":"Procidano","year":"1983","journal-title":"Am. J. Community Psychol."},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17197001","article-title":"The prevalence of depression, anxiety and stress and their associated factors in college students.","volume":"17","author":"Ram\u00f3n-Arbu\u00e9s","year":"2020","journal-title":"Int. J. Environm. Res. Public Health"},{"key":"B70","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1093\/clinchem\/42.7.1100","article-title":"Long-term stability of blood glutathione and cysteine in humans.","volume":"42","author":"Richie","year":"1996","journal-title":"Clin. Chem."},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-016-0810-0","article-title":"Anxiety and depression in Nepal: prevalence, comorbidity and associations.","volume":"16","author":"Risal","year":"2016","journal-title":"BMC Psychiatry"},{"key":"B72","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1016\/j.jad.2018.11.083","article-title":"Major depressive disorder in Mexican medical students and associated factors: a focus on current and past abuse experiences.","volume":"245","author":"Romo-Nava","year":"2019","journal-title":"J. Affect. Disord."},{"key":"B73","first-page":"3","article-title":"Ansiedad, depresi\u00f3n y modos de afrontamiento en estudiantes preuniversitarios.","volume":"3","author":"Rosas-Santiago","year":"2016","journal-title":"Salud Adm."},{"key":"B74","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1515\/9781400876136-019","author":"Rosenberg","year":"1965","journal-title":"Society And The Adolescent Self-Image."},{"key":"B75","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1124\/jpet.116.237503","article-title":"Oxidative stress and the central nervous system.","volume":"360","author":"Salim","year":"2017","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B76","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1708\/2891.29157","article-title":"Anxiety, depression and risk consumption of alcohol in a sample of university students.","volume":"53","author":"Santangelo","year":"2018","journal-title":"Riv. Psichiatr."},{"key":"B77","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1002\/da.22987","article-title":"Interpersonal life stress, inflammation, and depression in adolescence: testing social signal transduction theory of depression.","volume":"37","author":"Slavich","year":"2020","journal-title":"Depress. Anxiety"},{"key":"B78","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/j.pnpbp.2012.10.006","article-title":"Immune changes and neurotransmitters: possible interactions in depression?","volume":"48","author":"Sperner-Unterweger","year":"2014","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"B79","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.jad.2017.04.042","article-title":"Severity of anxiety\u2013but not depression\u2013is associated with oxidative stress in Major Depressive Disorder.","volume":"219","author":"Steenkamp","year":"2017","journal-title":"J. Affect. Disord."},{"key":"B80","doi-asserted-by":"publisher","first-page":"41","DOI":"10.29105\/respyn17.4-5","article-title":"Depression, anxiety and stress in new students entering to higher education.","volume":"17","author":"Tijerina Gonz\u00e1lez","year":"2018","journal-title":"RESPYN"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0188187","article-title":"Health assessment of French university students and risk factors associated with mental health disorders.","volume":"12","author":"Tran","year":"2017","journal-title":"PLoS One"},{"key":"B82","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/j.imbio.2014.02.010","article-title":"Reference ranges of lymphocyte subsets in healthy adults and adolescents with special mention of T cell maturation subsets in adults of South Florida.","volume":"219","author":"Valiathan","year":"2014","journal-title":"Immunobiology"},{"key":"B83","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.pnpbp.2017.02.017","article-title":"Oxidative stress and brain morphology in individuals with depression, anxiety and healthy controls.","volume":"76","author":"van Velzen","year":"2017","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"B84","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.17179\/excli2017-480","article-title":"The impact of stress on body function: a review.","volume":"16","author":"Yaribeygi","year":"2017","journal-title":"EXCLI J."},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare6040147","article-title":"Health contributing factors in higher education students: the importance of family and friends.","volume":"6","author":"Yubero","year":"2018","journal-title":"Healthcare"}],"container-title":["Frontiers in Psychology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpsyg.2021.666347\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T06:30:31Z","timestamp":1641364231000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpsyg.2021.666347\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,5]]},"references-count":84,"alternative-id":["10.3389\/fpsyg.2021.666347"],"URL":"https:\/\/doi.org\/10.3389\/fpsyg.2021.666347","relation":{},"ISSN":["1664-1078"],"issn-type":[{"value":"1664-1078","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,5]]},"article-number":"666347"}}