{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:02:59Z","timestamp":1792605779465,"version":"4.5.0"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T00:00:00Z","timestamp":1674000000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychol."],"abstract":"<jats:p>Patients with ATTR cardiac amyloidosis (ATTR-CA) face rare disease that could negatively influence psychological well-being with consequences on the course of the disease and quality of life. However, to date, no study analyzed the prevalence of anxiety and depression in patients with ATTR-CA and which clinical and sociodemographic characteristics are linked with these psychopathological conditions. A total of 109 consecutive patients (83% males) aged 62\u201390\u2009years with ATTR-CA were recruited. In order to better understand the prevalence of anxiety and depression in ATTR-CA, a control group composed by 33 individuals equaling gender, education, and age were recruited. The level of anxiety and depression was measured using the Italian version of the Hospital Anxiety and Depression Scale (HADS). Sociodemographic and clinic characteristics were registered. Almost half of patients (49%) reported a clinical level of depression or anxiety, or both. ATTR-CA patients reported higher levels of anxiety and depression than control group. Results showed that older patients with ATTR-CA, especially females, with more advanced disease could be more at risk to develop an anxious disorder. Furthermore, being a woman, and presenting with a greater severity of symptoms, would appear to be a risk factor for developing a depressive disorder. Overall, these results highlighted the high presence of anxiety and depression in ATTR-CA patients, suggesting to physicians to pay attention to the psychological well-being of ATTR-CA patients. In fact, a psychological support for patients with high level of psychopathological disease could reduce disease burden and improve quality of life in ATTR-CA population.<\/jats:p>","DOI":"10.3389\/fpsyg.2022.1066224","type":"journal-article","created":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T01:00:25Z","timestamp":1674003625000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":19,"title":["Prevalence of anxiety and depression symptoms in a sample of outpatients with ATTR cardiac amyloidosis"],"prefix":"10.3389","volume":"13","author":[{"given":"Martina","family":"Smorti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Ponti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Soffio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Argir\u00f2","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Perfetto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattia","family":"Zampieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlotta","family":"Mazzoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Tomberli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Allinovi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Di Mario","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iacopo","family":"Olivotto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Cappelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,1,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"e000881","DOI":"10.1136\/openhrt-2018-000881","article-title":"Role of cardiovascular imaging for the diagnosis and prognosis of cardiac amyloidosis","volume":"5","author":"Agha","year":"2018","journal-title":"Open Heart"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"e13598","DOI":"10.1111\/eci.13598","article-title":"Quality of life assessment in amyloid transthyretin (ATTR) amyloidosis","volume":"51","author":"Aimo","year":"2021","journal-title":"Eur. 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Heart J."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1016\/j.jacc.2016.06.033","article-title":"Natural history of wild-type transthyretin cardiac amyloidosis and risk stratification using a novel staging system","volume":"68","author":"Grogan","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1477-7525-12-84","article-title":"Confirmatory bifactor analysis of the hospital anxiety and depression scale in an Italian community sample","volume":"12","author":"Iani","year":"2014","journal-title":"Health Qual. Life Outcomes"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1177\/1747493019896958","article-title":"Frequency of anxiety after stroke: an updated systematic review and meta-analysis of observational studies","volume":"15","author":"Knapp","year":"2020","journal-title":"Int. J. 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Heart J."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1080\/13506129.2016.1208081","article-title":"Depression and anxiety in patients with AL amyloidosis as assessed by the SF-36 questionnaire: experience in 1226 patients","volume":"23","author":"Shu","year":"2016","journal-title":"Amyloid"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/j.hroo.2021.06.001","article-title":"Anxiety and depression in inherited channelopathy patients with implantable cardioverter-defibrillators","volume":"2","author":"Singh","year":"2021","journal-title":"Heart Rhythm."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"123","DOI":"10.3109\/13506129.2012.687420","article-title":"Anxiety and depression among AL amyloidosis patients: the role of cardiac symptoms","volume":"19","author":"Smorti","year":"2012","journal-title":"Amyloid"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1080\/13548506.2013.802357","article-title":"Depression and cardiac symptoms among AL amyloidosis patients: the mediating role of coping strategies","volume":"19","author":"Smorti","year":"2014","journal-title":"Psychol. Health Med."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1177\/1474515114566737","article-title":"Anxiety and depression among amyloid light-chain cardiac amyloidosis patients: the role of life satisfaction","volume":"15","author":"Smorti","year":"2016","journal-title":"Eur. J. Cardiovasc. Nurs."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1007\/s40120-018-0106-z","article-title":"Characterizing the high disease burden of transthyretin amyloidosis for patients and caregivers","volume":"7","author":"Stewart","year":"2018","journal-title":"Neurol. Therapy"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.ijcard.2021.04.023","article-title":"Changes in the perceived epidemiology of amyloidosis: 20 year-experience from a tertiary referral Centre in Tuscany","volume":"335","author":"Zampieri","year":"2021","journal-title":"Int. J. Cardiol."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1111\/j.1600-0447.1983.tb09716.x","article-title":"The hospital anxiety and depression scale","volume":"67","author":"Zigmond","year":"1983","journal-title":"Acta Psychiatr. 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