{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T10:32:30Z","timestamp":1790850750719,"version":"4.1.0"},"reference-count":85,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T00:00:00Z","timestamp":1673827200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971787 and 82072109"],"award-info":[{"award-number":["81971787 and 82072109"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Post-traumatic stress disorder (PTSD) has various risk factors, complex pathogenesis, and diverse symptoms, and is often comorbid with other injuries and diseases, making forensic diagnosis difficult.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>To explore the current research status and trends of PTSD, we used the Web of Science Core Collection databases to screen PTSD-related literature published between 2010 and 2021 and CiteSpace to perform bibliometric analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In recent years, PTSD-related research has grown steadily. The countries and institutions with the most research results were the United States and England, and King\u2019s College London and Boston University, respectively. Publications were identified from 2,821 different journals, including 13 forensic-related journals, but the journal distribution was relatively scattered and there was a lack of professional core journals. Keyword co-occurrence and clustering identified many hot topics; \u201crat model,\u201d \u201cmental health,\u201d and \u201csatisfaction\u201d were the topics most likely to have a clear effect on future research. Analysis extracted nine turning points from the literature that suggested that neural network centers, the hypothalamic\u2013pituitary\u2013adrenal axis, and biomarkers were new research directions. It was found that COVID-19 can cause severe psychological stress and induce PTSD, but the relationship needs further study. The literature on stress response areas and biomarkers has gradually increased over time, but specific systemic neural brain circuits and biomarkers remain to be determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There is a need to expand the collection of different types of biological tissue samples from patients with different backgrounds, screen PTSD biomarkers and molecular targets using multi-omics and molecular biology techniques, and establish PTSD-related molecular networks. This may promote a systematic understanding of the abnormal activation of neural circuits in patients with PTSD and help to establish a personalized, accurate, and objective forensic diagnostic standard.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpsyg.2022.1074999","type":"journal-article","created":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T04:50:33Z","timestamp":1673844633000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Bibliometric analysis of post-traumatic stress disorder in forensic medicine: Research trends, hot spots, and prospects"],"prefix":"10.3389","volume":"13","author":[{"given":"Weihao","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingmin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huihuang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weibo","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Cong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,1,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1097\/FBP.0000000000000460","article-title":"The predator odor avoidance model of post-traumatic stress disorder in rats","volume":"30","author":"Albrechet-Souza","year":"2019","journal-title":"Behav. Pharmacol."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1038\/s41586-019-0931-y","article-title":"Neural circuits underlying a psychotherapeutic regimen for fear disorders","volume":"566","author":"Baek","year":"2019","journal-title":"Nature"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"E8472","DOI":"10.1073\/pnas.1617824113","article-title":"Alterations in the neuropeptide galanin system in major depressive disorder involve levels of transcripts, methylation, and peptide","volume":"113","author":"Barde","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"17","DOI":"10.3390\/ijerph17239096","article-title":"Investigating the psychological impact of COVID-19 among healthcare workers: a meta-analysis","volume":"17","author":"Batra","year":"2020","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"e218","DOI":"10.1093\/milmed\/usy226","article-title":"Common data elements in the assessment of military-related PTSD research applied in the consortium to alleviate PTSD","volume":"184","author":"Ben","year":"2019","journal-title":"Mil. Med."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1016\/j.phrs.2016.07.024","article-title":"The endocannabinoid system and post traumatic stress disorder (PTSD): from preclinical findings to innovative therapeutic approaches in clinical settings","volume":"111","author":"Berardi","year":"2016","journal-title":"Pharmacol. Res."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"113","DOI":"10.3389\/fnbeh.2019.00113","article-title":"Stress across generations: DNA methylation as a potential mechanism underlying intergenerational effects of stress in both post-traumatic stress disorder and pre-clinical predator stress rodent models","volume":"13","author":"Bhattacharya","year":"2019","journal-title":"Front. Behav. Neurosci."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.4088\/JCP.09m05106blu","article-title":"Corticotropin-releasing factor, interleukin-6, brain-derived neurotrophic factor, insulin-like growth factor-1, and substance P in the cerebrospinal fluid of civilians with posttraumatic stress disorder before and after treatment with paroxetine","volume":"72","author":"Bonne","year":"2011","journal-title":"J. Clin. Psychiatry"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1503\/jpn.170021","article-title":"Mindfulness-based treatments for posttraumatic stress disorder: a review of the treatment literature and neurobiological evidence","volume":"43","author":"Boyd","year":"2018","journal-title":"J. Psychiatry Neurosci."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1037\/a0018113","article-title":"Intrusive images in psychological disorders: characteristics, neural mechanisms, and treatment implications","volume":"117","author":"Brewin","year":"2010","journal-title":"Psychol. Rev."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"e12643","DOI":"10.1111\/gbb.12643","article-title":"Sex differences: transcriptional signatures of stress exposure in male and female brains","volume":"19","author":"Brivio","year":"2020","journal-title":"Genes Brain Behav."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1017\/S0033291716002026","article-title":"Post-traumatic stress disorder associated with natural and human-made disasters in the world mental health surveys","volume":"47","author":"Bromet","year":"2017","journal-title":"Psychol. Med."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1136\/jramc-2017-000876","article-title":"Psychological resilience and post-traumatic growth in disaster-exposed organisations: overview of the literature","volume":"166","author":"Brooks","year":"2020","journal-title":"BMJ Mil. Health."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1177\/00258024211019624","article-title":"The right to mourn: post-traumatic stress and the forensic pathologist","volume":"61","author":"Byard","year":"2021","journal-title":"Med. Sci. Law"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"3022282110496","DOI":"10.1177\/00302228211049683","article-title":"Losing a loved one during the covid-19 pandemic: an on-line survey looking at the effects on traumatic stress, coping and post-traumatic growth","author":"Carson","year":"2021","journal-title":"Omega (Westport)."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1192\/bjo.2021.3","article-title":"Post-traumatic stress disorder symptoms in COVID-19 survivors: online population survey","volume":"7","author":"Chamberlain","year":"2021","journal-title":"B. J.Psychol. Open."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/j.bbi.2020.04.049","article-title":"A multinational, multicentre study on the psychological outcomes and associated physical symptoms amongst healthcare workers during COVID-19 outbreak","volume":"88","author":"Chew","year":"2020","journal-title":"Brain Behav. Immun."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"114353","DOI":"10.1016\/j.psychres.2021.114353","article-title":"Risk of post-traumatic stress symptoms in hospitalized and non-hospitalized COVID-19 recovered patients. A cross-sectional study","volume":"308","author":"Craparo","year":"2022","journal-title":"Psychiatry Res."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1503\/jpn.090175","article-title":"Switching between executive and default mode networks in posttraumatic stress disorder: alterations in functional connectivity","volume":"35","author":"Daniels","year":"2010","journal-title":"J. Psychiatry Neurosci."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/j.ecl.2013.05.004","article-title":"Endocrine aspects of post-traumatic stress disorder and implications for diagnosis and treatment","volume":"42","author":"Daskalakis","year":"2013","journal-title":"Endocrinol. Metab. Clin. N. Am."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1016\/j.dsx.2020.05.035","article-title":"Psychosocial impact of COVID-19","volume":"14","author":"Dubey","year":"2020","journal-title":"Diabetes Metab. Syndr."},{"key":"ref22","doi-asserted-by":"publisher","first-page":"1783","DOI":"10.1016\/S0140-6736(10)60672-1","article-title":"What are the consequences of deployment to Iraq and Afghanistan on the mental health of the UK armed forces? A cohort study","volume":"375","author":"Fear","year":"2010","journal-title":"Lancet"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1080\/00140139.2021.1974103","article-title":"The impaired healing hypothesis: a mechanism by which psychosocial stress and personal characteristics increase MSD risk?","volume":"65","author":"Gallagher","year":"2022","journal-title":"Ergonomics"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1111\/j.1471-4159.2009.06462.x","article-title":"Transcriptional expression of serotonergic regulators in laser-captured microdissected dorsal raphe neurons of subjects with major depressive disorder: sex-specific differences","volume":"112","author":"Goswami","year":"2010","journal-title":"J. Neurochem."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1093\/bmb\/ldv014","article-title":"Latest developments in post-traumatic stress disorder: diagnosis and treatment","volume":"114","author":"Greenberg","year":"2015","journal-title":"Br. Med. Bull."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1177\/0706743719895341","article-title":"A cross-sectional study of the relationship between previous military experience and mental health disorders in currently serving public safety personnel in Canada","volume":"65","author":"Groll","year":"2020","journal-title":"Can. J. Psychiatr."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/2045-5380-2-9","article-title":"Quantitative meta-analysis of neural activity in posttraumatic stress disorder","volume":"2","author":"Hayes","year":"2012","journal-title":"Biol. Mood Anxiety Disord."},{"key":"ref28","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.pnpbp.2018.11.003","article-title":"Neuroimaging research in posttraumatic stress disorder - focus on amygdala, hippocampus and prefrontal cortex","volume":"90","author":"Henigsberg","year":"2019","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.expneurol.2011.12.041","article-title":"Introduction: stress and neurological disease","volume":"233","author":"Herman","year":"2012","journal-title":"Exp. Neurol."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1586\/ern.10.198","article-title":"Functional neuroimaging studies of post-traumatic stress disorder","volume":"11","author":"Hughes","year":"2011","journal-title":"Expert. Rev. Neurother."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"1891734","DOI":"10.1080\/20008198.2021.1891734","article-title":"Probable post-traumatic stress disorder and harmful alcohol use among male members of the British police forces and the British armed forces: a comparative study","volume":"12","author":"Irizar","year":"2021","journal-title":"Eur. J. Psychotraumatol."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"337","DOI":"10.31887\/DCNS.2015.17.3\/akaczkurkin","article-title":"Cognitive-behavioral therapy for anxiety disorders: an update on the empirical evidence","volume":"17","author":"Kaczkurkin","year":"2015","journal-title":"Dialogues Clin. Neurosci."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.psyneuen.2018.12.226","article-title":"Allele-specific DNA methylation level of FKBP5 is associated with post-traumatic stress disorder","volume":"103","author":"Kang","year":"2019","journal-title":"Psychoneuroendocrinology"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"231","DOI":"10.24869\/psyd.2021.231","article-title":"Post-traumatic stress disorder and affecting factors in pregnant women in the COVID-19 pandemic","volume":"33","author":"Kara","year":"2021","journal-title":"Psychiatr. Danub."},{"key":"ref35","doi-asserted-by":"publisher","first-page":"3947","DOI":"10.21037\/apm-20-1829","article-title":"Correlation between monoamine neurotransmitter and cytokine levels and the occurrence of post-traumatic stress disorder among operating room nurses","volume":"9","author":"Ke","year":"2020","journal-title":"Ann. Palliat. Med."},{"key":"ref36","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1002\/mpr.1359","article-title":"Twelve-month and lifetime prevalence and lifetime morbid risk of anxiety and mood disorders in the United States","volume":"21","author":"Kessler","year":"2012","journal-title":"Int. J. Methods Psychiatr. Res."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1002\/wps.20150","article-title":"How well can post-traumatic stress disorder be predicted from pre-trauma risk factors? An exploratory study in the WHO world mental health surveys","volume":"13","author":"Kessler","year":"2014","journal-title":"World Psychiatry"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.pnpbp.2018.06.008","article-title":"A review on inflammatory cytokine-induced alterations of the brain as potential neural biomarkers in post-traumatic stress disorder","volume":"91","author":"Kim","year":"2019","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"9","DOI":"10.3390\/antiox9020107","article-title":"Inflammation in post-traumatic stress disorder (PTSD): a review of potential correlates of PTSD with a neurological perspective","volume":"9","author":"Kim","year":"2020","journal-title":"Antioxidants (Basel)."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1101\/lm.037291.114","article-title":"Stress effects on the hippocampus: a critical review","volume":"22","author":"Kim","year":"2015","journal-title":"Learn. Mem."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"9","DOI":"10.3390\/brainsci9100254","article-title":"Endocannabinoids and Fear-related behavior in mice selectively bred for high or low alcohol preference","volume":"9","author":"Kirchhoff","year":"2019","journal-title":"Brain Sci."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1111\/1556-4029.12606","article-title":"Failings of trauma-specific and related psychological tests in detecting post-traumatic stress disorder in forensic settings","volume":"60","author":"Kleinman","year":"2015","journal-title":"J. Forensic Sci."},{"key":"ref43","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1007\/s11916-000-0008-4","article-title":"Comorbidity of post-traumatic stress disorder and chronic pain: implications for clinical and forensic assessment","volume":"4","author":"Kulich","year":"2000","journal-title":"Curr. Rev. Pain"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1055\/s-2006-947837","article-title":"Metabolic syndrome and the endocrine stress system","volume":"38","author":"Lamounier-Zepter","year":"2006","journal-title":"Horm. Metab. Res."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1007\/s11886-016-0798-6","article-title":"Mental stress and ventricular arrhythmias","volume":"18","author":"Lampert","year":"2016","journal-title":"Curr. Cardiol. Rep."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1007\/s11682-020-00303-9","article-title":"Individuals with the post-traumatic stress disorder process emotions in subcortical regions irrespective of cognitive engagement: a meta-analysis of cognitive and emotional interface","volume":"15","author":"Lee","year":"2021","journal-title":"Brain Imaging Behav."},{"key":"ref47","doi-asserted-by":"publisher","first-page":"18","DOI":"10.3390\/ijerph18020771","article-title":"COVID-19 stress and mental health of students in locked-down colleges","volume":"18","author":"Li","year":"2021","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"105330","DOI":"10.1016\/j.compbiomed.2022.105330","article-title":"A bibliometric analysis of the cause of sudden unexplained death in forensic medicine: research trends, hot spots and prospects","volume":"144","author":"Li","year":"2022","journal-title":"Comput. Biol. Med."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1177\/1359105320937057","article-title":"Post-traumatic stress disorder and psychological distress in Chinese youths following the COVID-19 emergency","volume":"25","author":"Liang","year":"2020","journal-title":"J. Health Psychol."},{"key":"ref50","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1111\/cns.13431","article-title":"COVID-19 and post-traumatic stress disorder: a vicious circle involving immunosuppression","volume":"26","author":"Liang","year":"2020","journal-title":"CNS Neurosci. Ther."},{"key":"ref51","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1192\/bjp.bp.117.205955","article-title":"Trauma and psychotic experiences: transnational data from the world mental health survey","volume":"211","author":"McGrath","year":"2017","journal-title":"Br. J. Psychiatry"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1192\/bjp.bp.116.197640","article-title":"Childhood adversities and post-traumatic stress disorder: evidence for stress sensitisation in the world mental health surveys","volume":"211","author":"McLaughlin","year":"2017","journal-title":"Br. J. Psychiatry"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1016\/j.biopsych.2009.06.026","article-title":"Neurobiological basis of failure to recall extinction memory in posttraumatic stress disorder","volume":"66","author":"Milad","year":"2009","journal-title":"Biol. Psychiatry"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"22","DOI":"10.3390\/ijms22115964","article-title":"Glucocorticoid signaling and epigenetic alterations in stress-related disorders","volume":"22","author":"Mourtzi","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"ref55","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1038\/mp.2009.29","article-title":"Mental disorders, comorbidity and suicidal behavior: results from the National Comorbidity Survey Replication","volume":"15","author":"Nock","year":"2010","journal-title":"Mol. Psychiatry"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.neubiorev.2012.10.013","article-title":"Exaggerated neurobiological sensitivity to threat as a mechanism linking anxiety with increased risk for diseases of aging","volume":"37","author":"O'Donovan","year":"2013","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref57","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s40560-020-0427-8","article-title":"Impact of the stress ulcer prophylactic protocol on reducing the unnecessary administration of stress ulcer medications and gastrointestinal bleeding: a single-center, retrospective pre-post study","volume":"8","author":"Ogasawara","year":"2020","journal-title":"J. Intensive Care"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1038\/nrn3339","article-title":"Biological studies of post-traumatic stress disorder","volume":"13","author":"Pitman","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"key":"ref60","volume-title":"QS World University Rankings 2023","year":"2022"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1111\/acps.12418","article-title":"Intrinsic connectivity networks in post-traumatic stress disorder during sub-and supraliminal processing of threat-related stimuli","volume":"132","author":"Rabellino","year":"2015","journal-title":"Acta Psychiatr. Scand."},{"key":"ref62","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1038\/nature09856","article-title":"Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor","volume":"470","author":"Ressler","year":"2011","journal-title":"Nature"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"6953156","DOI":"10.1155\/2017\/6953156","article-title":"Integrated stress response as a therapeutic target for CNS injuries","volume":"2017","author":"Romero-Ramirez","year":"2017","journal-title":"Biomed. Res. Int."},{"key":"ref64","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1038\/mp.2015.230","article-title":"The effects of stress on brain and adrenal stem cells","volume":"21","author":"Rubin","year":"2016","journal-title":"Mol. Psychiatry"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"e58150","DOI":"10.1371\/journal.pone.0058150","article-title":"In search of the trauma memory: a meta-analysis of functional neuroimaging studies of symptom provocation in posttraumatic stress disorder (PTSD)","volume":"8","author":"Sartory","year":"2013","journal-title":"PLoS One"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1017\/S0033291717001593","article-title":"Post-traumatic stress disorder associated with sexual assault among women in the WHO world mental health surveys","volume":"48","author":"Scott","year":"2018","journal-title":"Psychol. Med."},{"key":"ref67","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1038\/npp.2009.83","article-title":"The neurocircuitry of fear, stress, and anxiety disorders","volume":"35","author":"Shin","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1002\/ajmg.b.31212","article-title":"Differential immune system DNA methylation and cytokine regulation in post-traumatic stress disorder","volume":"156","author":"Smith","year":"2011","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"ref69","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/j.jad.2021.08.044","article-title":"Impact of the COVID-19 pandemic on older adults living in long-term care centers in Thailand, and risk factors for post-traumatic stress, depression, and anxiety","volume":"295","author":"Srifuengfung","year":"2021","journal-title":"J. Affect. Disord."},{"key":"ref70","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1097\/PSY.0b013e318273bf33","article-title":"Neural dysregulation in posttraumatic stress disorder: evidence for disrupted equilibrium between salience and default mode brain networks","volume":"74","author":"Sripada","year":"2012","journal-title":"Psychosom. Med."},{"key":"ref71","doi-asserted-by":"publisher","first-page":"827","DOI":"10.4103\/1673-5374.232477","article-title":"Inhibition of endoplasmic reticulum stress alleviates secondary injury after traumatic brain injury","volume":"13","author":"Tan","year":"2018","journal-title":"Neural Regen. Res."},{"key":"ref72","doi-asserted-by":"publisher","first-page":"2405","DOI":"10.3969\/j.issn.1673-5374.2013.26.001","article-title":"Brain structure in post-traumatic stress disorder: a voxel-based morphometry analysis","volume":"8","author":"Tan","year":"2013","journal-title":"Neural Regen. Res."},{"key":"ref73","doi-asserted-by":"publisher","first-page":"100789","DOI":"10.1016\/j.yfrne.2019.100789","article-title":"Stress and drug abuse-related disorders: the promising therapeutic value of neurosteroids focus on pregnenolone-progesterone-allopregnanolone pathway","volume":"55","author":"Tomaselli","year":"2019","journal-title":"Front. Neuroendocrinol."},{"key":"ref74","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.nbd.2011.01.014","article-title":"Reduced somatostatin in subgenual anterior cingulate cortex in major depression","volume":"42","author":"Tripp","year":"2011","journal-title":"Neurobiol. Dis."},{"key":"ref75","volume-title":"King's College London in United Kingdom - US News Best Global Universities","year":"2022"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.biopsych.2011.10.026","article-title":"Glucocorticoid receptor pathway components predict posttraumatic stress disorder symptom development: a prospective study","volume":"71","author":"van Zuiden","year":"2012","journal-title":"Biol. Psychiatry"},{"key":"ref77","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.bbi.2020.04.028","article-title":"A longitudinal study on the mental health of general population during the COVID-19 epidemic in China","volume":"87","author":"Wang","year":"2020","journal-title":"Brain Behav. Immun."},{"key":"ref78","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.jad.2020.08.001","article-title":"Impact of COVID-19 pandemic on mental health in the general population: a systematic review","volume":"277","author":"Xiong","year":"2020","journal-title":"J. Affect. Disord."},{"key":"ref79","doi-asserted-by":"publisher","first-page":"15057","DOI":"10.1038\/nrdp.2015.57","article-title":"Post-traumatic stress disorder","volume":"1","author":"Yehuda","year":"2015","journal-title":"Nat. Rev. Dis. Primers."},{"key":"ref80","doi-asserted-by":"publisher","first-page":"190","DOI":"10.3389\/fncel.2019.00190","article-title":"Endoplasmic reticulum stress is involved in stress-induced hypothalamic neuronal injury in rats via the PERK-ATF4-CHOP and IRE1-ASK1-JNK pathways","volume":"13","author":"Yi","year":"2019","journal-title":"Front. Cell. Neurosci."},{"key":"ref81","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1017\/S0033291720002949","article-title":"Stress-related cognitive style is related to volumetric change of the hippocampus and FK506 binding protein 5 polymorphism in post-traumatic stress disorder","volume":"52","author":"Yun","year":"2022","journal-title":"Psychol. Med."},{"key":"ref82","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1016\/j.yexcr.2012.01.006","article-title":"Endoplasmic reticulum stress contributes to CRH-induced hippocampal neuron apoptosis","volume":"318","author":"Zhang","year":"2012","journal-title":"Exp. Cell Res."},{"key":"ref83","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.physbeh.2014.04.014","article-title":"Endoplasmic reticulum stress is involved in restraint stress-induced hippocampal apoptosis and cognitive impairments in rats","volume":"131","author":"Zhang","year":"2014","journal-title":"Physiol. Behav."},{"key":"ref84","doi-asserted-by":"publisher","first-page":"17","DOI":"10.3390\/ijerph17072381","article-title":"Impact of the COVID-19 pandemic on mental health and quality of life among local residents in Liaoning province, China: a cross-sectional study","volume":"17","author":"Zhang","year":"2020","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"ref85","doi-asserted-by":"publisher","first-page":"844","DOI":"10.5137\/1019-5149.JTN.8723-13.1","article-title":"Altered neurotransmitter levels with post-traumatic stress disorder","volume":"24","author":"Zhang","year":"2014","journal-title":"Turk. Neurosurg."}],"container-title":["Frontiers in Psychology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpsyg.2022.1074999\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T04:50:38Z","timestamp":1673844638000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpsyg.2022.1074999\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,16]]},"references-count":85,"alternative-id":["10.3389\/fpsyg.2022.1074999"],"URL":"https:\/\/doi.org\/10.3389\/fpsyg.2022.1074999","relation":{},"ISSN":["1664-1078"],"issn-type":[{"value":"1664-1078","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,16]]},"article-number":"1074999"}}