{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:23:45Z","timestamp":1753892625529,"version":"3.41.2"},"reference-count":34,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T00:00:00Z","timestamp":1681948800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychol."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>It has been frequently suggested that overall genomic heterozygosity and, particularly, heterozygosity of loci on the so-called major histocompatibility complex (MHC), which is responsible for the recognition of foreign substances\/ pathogens and the recognition of self and non-self, is associated with better health and better resistance to infections and parasites. It has further been speculated that such a potentially beneficial heterozygosity can be detected through body odor and facial attractiveness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>On the basis of genome wide SNP data (713,014 SNPs) of participants from the Wisconsin Longitudinal Study, we therefore investigated whether homozygosity either on the MHC (measured as inbreeding coefficient) or genome-wide (measured as runs of homozygosity and inbreeding coefficient) is associated with rated facial attractiveness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Although we found that the genome-wide average length of homozygous segments and the genome-wide inbreeding coefficient are significantly negatively associated with some measures of facial attractiveness, if corrected for multiple testing, any significant association was no longer formally significant after correction. In addition, the variance in facial attractiveness explained by the genome wide homozygosity is very low (&amp;lt;0.15%). We did not find any significant association between the inbreeding coefficient on the MHC and facial attractiveness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>We only find a weak association of genome- wide heterozygosity and facial attractiveness.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpsyg.2023.1009962","type":"journal-article","created":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T19:43:29Z","timestamp":1682019809000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Facial attractiveness is only weakly linked to genome\u2013wide heterozygosity"],"prefix":"10.3389","volume":"14","author":[{"given":"Martin","family":"Fieder","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Huber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,4,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1007\/s10519-013-9610-1","article-title":"Association between autozygosity and major depression: Stratification due to religious assortment","volume":"43","author":"Abdellaoui","year":"2013","journal-title":"Behav. Genet."},{"year":"2021","author":"Benjamin","key":"ref2"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1046\/j.1420-9101.2003.00531.x","article-title":"MHC studies in nonmodel vertebrates: What have we learned about natural selection in 15 years?","volume":"16","author":"Bernatchez","year":"2003","journal-title":"J. Evol. Biol."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1038\/nrg.2017.109","article-title":"Runs of homozygosity: Windows into population history and trait architecture","volume":"19","author":"Ceballos","year":"2018","journal-title":"Nat. Rev. Genet."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-019-12283-6","article-title":"Associations of autozygosity with a broad range of human phenotypes","volume":"10","author":"Clark","year":"2019","journal-title":"Nat. Commun."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"e640","DOI":"10.1371\/journal.pone.0000640","article-title":"Common HLA alleles associated with health, but not with facial attractiveness","volume":"2","author":"Coetzee","year":"2007","journal-title":"PLoS One"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"20201800","DOI":"10.1098\/rspb.2020.1800","article-title":"Marriage does not relate to major histocompatibility complex: A genetic analysis based on 3691 couples","volume":"287","author":"Croy","year":"2020","journal-title":"Proc. R. Soc. B"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"20182664","DOI":"10.1098\/rspb.2018.2664","article-title":"Genomic evidence for MHC disassortative mating in humans","volume":"286","author":"Dandine-Roulland","year":"2019","journal-title":"Proc. R. Soc. B"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1757","DOI":"10.2307\/2640438","article-title":"Heterosis and outbreeding depression in interpopulation crosses spanning a wide range of divergence","volume":"53","author":"Edmands","year":"1999","journal-title":"Evolution"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/j.psyneuen.2008.10.007","article-title":"MHC-correlated mate choice in humans: A review","volume":"34","author":"Havli\u010dek","year":"2009","journal-title":"Psychoneuroendocrinology"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"20190260","DOI":"10.1098\/rstb.2019.0260","article-title":"Major histocompatibility complex-associated odour preferences and human mate choice: Near and far horizons","volume":"375","author":"Havl\u00ed\u010dek","year":"2020","journal-title":"Philos. Trans. R. Soc. 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Commun."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2164-12-460","article-title":"Detecting autozygosity through runs of homozygosity: A comparison of three autozygosity detection algorithms","volume":"12","author":"Howrigan","year":"2011","journal-title":"BMC Genomics"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"e1007973","DOI":"10.1371\/journal.pgen.1007973","article-title":"Genome-wide association study reveals sex-specific genetic architecture of facial attractiveness","volume":"15","author":"Hu","year":"2019","journal-title":"PLoS Genet."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"147470491401200","DOI":"10.1177\/147470491401200514","article-title":"Effects of parental socio-economic conditions on facial attractiveness","volume":"12","author":"Huber","year":"2014","journal-title":"Evol. Psychol."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1016\/j.evolhumbehav.2009.03.006","article-title":"Physical attractiveness and reproductive success in humans: Evidence from the late 20th century United States","volume":"30","author":"Jokela","year":"2009","journal-title":"Evol. Hum. Behav."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1038\/nature14618","article-title":"Directional dominance on stature and cognition in diverse human populations","volume":"523","author":"Joshi","year":"2015","journal-title":"Nature"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"5151","DOI":"10.1111\/mec.12934","article-title":"A quantitative review of MHC-based mating preference: The role of diversity and dissimilarity","volume":"23","author":"Kamiya","year":"2014","journal-title":"Mol. Ecol."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1534\/genetics.111.130922","article-title":"Quantification of inbreeding due to distant ancestors and its detection using dense single nucleotide polymorphism data","volume":"189","author":"Keller","year":"2011","journal-title":"Genetics"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/978-94-009-0077-6_9","article-title":"MHC polymorphism and parasites","volume-title":"Infection, polymorphism and evolution","author":"Klein","year":"1997"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.evolhumbehav.2015.08.003","article-title":"Facial averageness and genetic quality: Testing heritability, genetic correlation with attractiveness, and the paternal age effect","volume":"37","author":"Lee","year":"2016","journal-title":"Evol. Hum. Behav."},{"key":"ref22","doi-asserted-by":"publisher","first-page":"2473","DOI":"10.1111\/j.1558-5646.2008.00478.x","article-title":"Genetic diversity revealed in human faces","volume":"62","author":"Lie","year":"2008","journal-title":"Evolution"},{"volume-title":"An introduction to statistical genetic data analysis","year":"2020","author":"Mills","key":"ref23"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"11260","DOI":"10.1073\/pnas.162006499","article-title":"MHC heterozygosity confers a selective advantage against multiple-strain infections","volume":"99","author":"Penn","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1016\/j.evolhumbehav.2012.05.005","article-title":"Cues to fertility: Perceived attractiveness and facial shape predict reproductive success","volume":"33","author":"Pfl\u00fcger","year":"2012","journal-title":"Evol. Hum. Behav."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"53","DOI":"10.3390\/genes9010053","article-title":"MHC-dependent mate selection within 872 spousal pairs of European ancestry from the health and retirement study","volume":"9","author":"Qiao","year":"2018","journal-title":"Genes"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.evolhumbehav.2004.09.002","article-title":"MHC-heterozygosity and human facial attractiveness","volume":"26","author":"Roberts","year":"2005","journal-title":"Evol. Hum. Behav."},{"volume-title":"Produced and distributed by the University of Wisconsin with funding from the National Institute of aging (Grant numbers R01AG009775, R01AG033285 and Ro1AG041868)","year":"2021","key":"ref28"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1093\/beheco\/arg043","article-title":"Major histocompatibility complex genes, symmetry, and body scent attractiveness in men and women","volume":"14","author":"Thornhill","year":"2003","journal-title":"Behav. Ecol."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1126\/science.1088293","article-title":"Parasite selection for immunogenetic optimality","volume":"301","author":"Wegner","year":"2003","journal-title":"Science"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"73","DOI":"10.2147\/RRB.S58514","article-title":"Examining the evidence for major histocompatibility complex-dependent mate selection in humans and nonhuman primates","volume":"6","author":"Winternitz","year":"2015","journal-title":"Res. Rep. Biol."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1111\/mec.13920","article-title":"Patterns of MHC-dependent mate selection in humans and nonhuman primates: A meta-analysis","volume":"26","author":"Winternitz","year":"2017","journal-title":"Mol. Ecol."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/j.evolhumbehav.2018.04.001","article-title":"More than skin deep: Major histocompatibility complex (MHC)-based attraction among Asian American speed-daters","volume":"39","author":"Wu","year":"2018","journal-title":"Evol. Hum. Behav."},{"key":"ref34","doi-asserted-by":"publisher","first-page":"1633","DOI":"10.1073\/pnas.1808659116","article-title":"Facial masculinity does not appear to be a condition-dependent male ornament and does not reflect MHC heterozygosity in humans","volume":"116","author":"Zaidi","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. 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