{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T18:33:07Z","timestamp":1782585187413,"version":"3.54.5"},"reference-count":57,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,1,5]],"date-time":"2024-01-05T00:00:00Z","timestamp":1704412800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychol."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>With the rapid increase in the population over 65\u2009years old, research on healthy aging has become one of the priorities in the research community, looking for a cost-effective method to prevent or delay symptoms of mild cognitive disorder or dementia. Studies indicate that cognitive reserve theory could be beneficial in this regard. The aim of this study was to investigate the potential relationship between lifestyle socio-behavioral proxies of cognitive reserve and cortical regions in adults with no subjective cognitive decline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Overall, 58 participants, aged 65\u201385\u2009years, were included in the data analysis (<jats:italic>M\u2009<\/jats:italic>=\u200971.83, SD\u2009=\u20095.02, 20.7% male). Cognitive reserve proxies were measured using the Cognitive Reserve Index questionnaire, while cortical volumes were obtained with the Siemens 1.5\u2009T Avanto MRI scanner and further mapped using the Desikan-Killiany-Tourville (DKT) Atlas. Estimated intracranial volume and age were used as covariates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results indicated that higher occupational complexity was associated with larger cortical volume in the left middle temporal gyrus, the left and right inferior temporal gyrus, and the left inferior parietal lobule, while a combined proxy (the total CRI score) showed a positive relationship with the volume of left middle temporal gyrus and inferior parietal lobule, and pars orbitalis in the right hemisphere.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>These results might indicate that more complex occupational activities and overall more intellectually and socially active life-style could contribute to better brain health, especially in regions known to be more vulnerable to Alzheimer\u2019s disease.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpsyg.2023.1308434","type":"journal-article","created":{"date-parts":[[2024,1,5]],"date-time":"2024-01-05T05:42:50Z","timestamp":1704433370000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Relationship between lifestyle proxies of cognitive reserve and cortical regions in older adults"],"prefix":"10.3389","volume":"14","author":[{"given":"Kristine","family":"\u0160neidere","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nauris","family":"Zdanovskis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Mondini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ainars","family":"Stepens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,1,5]]},"reference":[{"key":"ref1","year":""},{"key":"ref2","doi-asserted-by":"publisher","first-page":"34","DOI":"10.3389\/FNINS.2019.00034\/BIBTEX","article-title":"Desikan-Killiany-Tourville atlas compatible version of m-CRIB neonatal parcellated whole brain atlas: the m-Crib 2.0","volume":"13","author":"Alexander","year":"2019","journal-title":"Front. Neurosci."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1615","DOI":"10.1080\/23279095.2021.1872079","article-title":"Cognitive reserve and brain maintenance in aging and dementia: an integrative review","volume":"29","author":"Alvares Pereira","year":"2022","journal-title":"Appl. Neuropsychol. Adult"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1016\/j.neuroimage.2013.06.053","article-title":"Relationships between years of education and gray matter volume, metabolism and functional connectivity in healthy elders","volume":"83","author":"Arenaza-Urquijo","year":"2013","journal-title":"NeuroImage"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1111\/opo.12131","article-title":"When to use the Bonferroni correction","volume":"34","author":"Armstrong","year":"2014","journal-title":"Ophthalmic Physiol. 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Neuropsychol."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1186\/s13195-021-00870-z","article-title":"Verbal intelligence is a more robust cross-sectional measure of cognitive reserve than level of education in healthy older adults","volume":"13","author":"Boyle","year":"2021","journal-title":"Alzheimer\u2019s Res. Ther."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1159\/000452276","article-title":"An international evaluation of cognitive reserve and memory changes in early old age in 10 European countries","volume":"48","author":"Cadar","year":"2017","journal-title":"Neuroepidemiology"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1780","DOI":"10.1007\/S00415-020-10331-6","article-title":"Effect of cognitive reserve on structural and functional MRI measures in healthy subjects: a multiparametric assessment","volume":"268","author":"Conti","year":"2021","journal-title":"J. Neurol."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1038\/NRN3963","article-title":"Rethinking segregation and integration: contributions of whole-brain modelling","volume":"16","author":"Deco","year":"2015","journal-title":"Nat. Rev. Neurosci."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1207988","DOI":"10.3389\/fpsyg.2023.1207988","article-title":"Resting-state functional connectivity is modulated by cognitive reserve in early Parkinson\u2019s disease","volume":"14","author":"Di Tella","year":"2023","journal-title":"Front. Psychol."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"835","DOI":"10.5604\/12321966.1129943","article-title":"Biological psychological and social determinants of old age: bio-psycho-social aspects of human aging","volume":"21","author":"Dziechcia\u017c","year":"2014","journal-title":"Ann. Agric. Environ. Med."},{"key":"ref15","article-title":"Life expectancy across EU regions in 2020","year":"2022"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1382","DOI":"10.1038\/s41598-020-80866-1","article-title":"The developmental trajectories of executive function from adolescence to old age","volume":"11","author":"Ferguson","year":"2021","journal-title":"Sci. Rep."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/J.TICS.2018.01.010","article-title":"How to characterize the function of a brain region","volume":"22","author":"Genon","year":"2018","journal-title":"Trends Cogn. Sci."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"4185","DOI":"10.1007\/s10072-022-05985-1","article-title":"Effect of cognitive reserve on cognitive function in Parkinson\u2019s disease","volume":"43","author":"Gu","year":"2022","journal-title":"Neurol. 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Disord."},{"key":"ref21","year":""},{"key":"ref22","doi-asserted-by":"publisher","first-page":"e0219851","DOI":"10.1371\/journal.pone.0219851","article-title":"Measuring cognitive reserve (CR) \u2013 A systematic review of measurement properties of CR questionnaires for the adult population","volume":"14","author":"Kartschmit","year":"2019","journal-title":"PLoS One"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1002\/ANA.410230206","article-title":"Clinical, pathological, and neurochemical changes in dementia: a subgroup with preserved mental status and numerous neocortical plaques","volume":"23","author":"Katzman","year":"1988","journal-title":"Ann. Neurol."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1515\/TNSCI-2017-0018","article-title":"The arcuate fasciculus network and verbal deficits in psychosis","volume":"8","author":"Kenney","year":"2017","journal-title":"Transl. 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Funct."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1007\/s00234-012-1005-0","article-title":"Education increases reserve against Alzheimer\u2019s disease-evidence from structural MRI analysis","volume":"54","author":"Liu","year":"2012","journal-title":"Neuroradiology"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/S0140-6736(20)30367-6\/ATTACHMENT\/CEE43A30-904B-4A45-A4E5-AFE48804398D\/MMC1.PDF","article-title":"Dementia prevention, intervention, and care: 2020 report of the lancet commission","volume":"396","author":"Livingston","year":"2020","journal-title":"Lancet"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"e50940","DOI":"10.1371\/JOURNAL.PONE.0050940","article-title":"Active cognitive lifestyle is associated with positive cognitive health transitions and compression of morbidity from age sixty-five","volume":"7","author":"Marioni","year":"2012","journal-title":"PLoS One"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"3310","DOI":"10.1002\/HBM.23242","article-title":"The functional connectome of cognitive reserve","volume":"37","author":"Marques","year":"2016","journal-title":"Hum. 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