{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:26:01Z","timestamp":1791840361086,"version":"4.3.4"},"reference-count":109,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T00:00:00Z","timestamp":1718841600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychol."],"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>To map studies assessing both clinical high risk for psychosis (CHR-P) and borderline personality disorder (BPD) in clinical samples, focusing on clinical\/research\/preventive paradigms and proposing informed research recommendations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a PRISMA-ScR\/JBI-compliant scoping review (protocol: <jats:ext-link>https:\/\/osf.io\/8mz7a<\/jats:ext-link>) of primary research studies (cross-sectional\/longitudinal designs) using valid measures\/criteria to assess CHR-P and BPD (threshold\/subthreshold) in clinical samples, reporting on CHR-P\/psychotic symptoms and personality disorder(s) in the title\/abstract\/keywords, identified in Web of Science\/PubMed\/(EBSCO)PsycINFO until 23\/08\/2023.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>33 studies were included and categorized into four themes reflecting their respective clinical\/research\/preventive paradigm: (i) BPD as a comorbidity in CHR-P youth (<jats:italic>k<\/jats:italic> =\u200920), emphasizing early detection and intervention in psychosis; (ii) attenuated psychosis syndrome (APS) as a comorbidity among BPD inpatients (<jats:italic>k<\/jats:italic> =\u20092), with a focus on hospitalized adolescents\/young adults admitted for non-psychotic mental disorders; (iii) mixed samples (<jats:italic>k<\/jats:italic> =\u20097), including descriptions of early intervention services and referral pathways; (iv) transdiagnostic approaches (<jats:italic>k<\/jats:italic> =\u20094) highlighting \u201cclinical high at risk mental state\u201d (CHARMS) criteria to identify a pluripotent risk state for severe mental disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The scoping review reveals diverse approaches to clinical care for CHR-P and BPD, with no unified treatment strategies. Recommendations for future research should focus on: (i) exploring referral pathways across early intervention clinics to promote timely intervention; (ii) enhancing early detection strategies in innovative settings such as emergency departments; (iii) improving mental health literacy to facilitate help-seeking behaviors; (iv) analysing comorbid disorders as complex systems to better understand and target early psychopathology; (v) investigating prospective risk for BPD; (vi) developing transdiagnostic interventions; (vii) engaging youth with lived experience of comorbidity to gain insight on their subjective experience; (viii) understanding caregiver burden to craft family-focused interventions; (ix) expanding research in underrepresented regions such as Africa and Asia, and; (x) evaluating the cost-effectiveness of early interventions to determine scalability across different countries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Systematic Review Registration<\/jats:title><jats:p><jats:ext-link>https:\/\/osf.io\/8mz7a<\/jats:ext-link>.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpsyg.2024.1381864","type":"journal-article","created":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T15:49:31Z","timestamp":1718898571000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Harmonizing early intervention strategies: scoping review of clinical high risk for psychosis and borderline personality disorder"],"prefix":"10.3389","volume":"15","author":[{"given":"Gabriele","family":"Lo Buglio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommaso","family":"Boldrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Polari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia","family":"Fiorentino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barnaby","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Solmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vittorio","family":"Lingiardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Tanzilli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,6,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1192\/bjp.2018.298","article-title":"Cost-effectiveness of early intervention in psychosis: systematic review","volume":"215","author":"Aceituno","year":"2019","journal-title":"Br. 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