{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T14:11:31Z","timestamp":1779199891577,"version":"3.51.4"},"reference-count":54,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T00:00:00Z","timestamp":1727395200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Fibromyalgia (FM) is characterized by widespread chronic pain. Although pain is the main symptom, approximately 90% of patients have depression. This study aimed to analyze the effects of Resistance Training (RT) with low and high intensity on depression in patients with FM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty-eight women with FM and 31 healthy women were allocated to the low-intensity, high-intensity, preferred-intensity, and control groups. The patients underwent 8 weeks of supervised RT, with two sessions per week of approximately 1 h. The low-intensity resistance training group (LIRT) performed two sets of 12 maximum repetitions. The high-intensity resistance training group (HIRT) performed four sets with six maximum repetitions, and the preferred intensity group (PI) performed three sets, with eight to 12 repetitions, according to the patient\u2019s tolerance. The healthy control group did not perform any type of exercise. Depression was assessed using the Beck depression inventory before the start of the intervention, after 4 and 8\u2009weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>FM patients have higher levels of depression than women without the disease. After 4\u2009weeks, there was a difference in depressive symptoms between the HIRT and LIRT (<jats:italic>p<\/jats:italic>\u2009=\u20090.048), and the PI and LIRT (<jats:italic>p<\/jats:italic>\u2009=\u20090.048).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Prescribing RT with low or high intensity did not significantly reduce depression in patients with FM after 8\u2009weeks, however, analyses between groups after 4\u2009weeks indicated that low-intensity training is more effective than high-intensity training. The prescription of RT exercise to FM could vary among low, high, and preferred intensity, following the patient\u2019s tolerance for pain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical trial registration<\/jats:title><jats:p><jats:ext-link>https:\/\/ensaiosclinicos.gov.br\/rg\/RBR-74pcmw<\/jats:ext-link>, RBR-74pcmw.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpsyg.2024.1400590","type":"journal-article","created":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T04:53:51Z","timestamp":1727412831000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["The impact of exercise intensity on depression in fibromyalgia: a randomized controlled trial"],"prefix":"10.3389","volume":"15","author":[{"given":"Guilherme Torres","family":"Vilarino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danilo Reis","family":"Coimbra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrique Pereira","family":"Neiva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandro","family":"Andrade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,9,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1149268","DOI":"10.3389\/FNEUR.2023.1149268","article-title":"Effects of strength training in fibromyalgia on balance, neuromuscular performance, and symptomatic analysis: a 12-week study protocol","volume":"14","author":"Albuquerque","year":"2023","journal-title":"Front. 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Disord."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1016\/j.pmrj.2018.09.032","article-title":"Resistance training improves quality of life and associated factors in patients with fibromyalgia syndrome","volume":"11","author":"Andrade","year":"2019","journal-title":"PM R"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"101195","DOI":"10.1016\/j.ctcp.2020.101195","article-title":"Preferred exercise and mental health of the patients with fibromyalgia syndrome","volume":"40","author":"Andrade","year":"","journal-title":"Complement. Ther. Clin. Pract."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1177\/1359105317751615","article-title":"The relationship between sleep quality and fibromyalgia symptoms","volume":"25","author":"Andrade","year":"","journal-title":"J. Health Psychol."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.jneuroim.2017.12.007","article-title":"Acute effects of physical exercises on the inflammatory markers of patients with fibromyalgia syndrome: A systematic review","volume":"316","author":"Andrade","year":"","journal-title":"J. Neuroimmunol."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"13s","DOI":"10.1590\/S1518-8787.2016050006117","article-title":"Prevalence of self-medication in Brazil and associated factors","volume":"50","author":"Arrais","year":"2016","journal-title":"Rev. Saude Publica"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"663","DOI":"10.23736\/s1973-9087.17.04876-6","article-title":"Muscle stretching exercises and resistance training in fibromyalgia: which is better? A three-arm randomized controlled trial","volume":"54","author":"Assump\u00e7\u00e3o","year":"2018","journal-title":"Eur. J. Phys. Rehabil. Med."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1865","DOI":"10.1016\/j.apmr.2020.05.022","article-title":"Effectiveness of high-intensity interval training vs moderate-intensity continuous training in patients with fibromyalgia: A pilot randomized controlled trial","volume":"101","author":"Atan","year":"2020","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1177\/13591053231172288","article-title":"Effects of resistance training on sleep of patients with fibromyalgia: A systematic review","volume":"28","author":"Bastos","year":"2023","journal-title":"J. Health Psychol."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1001\/archpsyc.1961.01710120031004","article-title":"An inventory for measuring depression","volume":"4","author":"Beck","year":"1961","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2012\/426130","article-title":"Fibromyalgia syndrome: etiology, pathogenesis, diagnosis, and treatment","volume":"2012","author":"Bellato","year":"2012","journal-title":"Pain Res. Treat."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1007\/s00296-007-0484-5","article-title":"Effects of muscle strengthening versus aerobic exercise program in fibromyalgia","volume":"28","author":"Bircan","year":"2008","journal-title":"Rheumatol. Int."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"e000166","DOI":"10.1136\/rmdopen-2015-000166","article-title":"Prevalence of rheumatic and musculoskeletal diseases and their impact on health-related quality of life, physical function and mental health in Portugal: results from epi Reuma Pt-a national health survey","volume":"2","author":"Branco","year":"2016","journal-title":"RMD Open"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1016\/j.jpain.2015.06.004","article-title":"Bidirectional association between depression and fibromyalgia syndrome: A Nationwide longitudinal study","volume":"16","author":"Chang","year":"2015","journal-title":"J. Pain"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1038\/bjc.2014.612","article-title":"Randomised controlled trial on the effectiveness of home-based walking exercise on anxiety, depression and cancer-related symptoms in patients with lung cancer","volume":"112","author":"Chen","year":"2014","journal-title":"Br. J. Cancer"},{"key":"ref19","doi-asserted-by":"crossref","DOI":"10.4324\/9780203771587","volume-title":"Statistical power analysis for the behavioral sciences","author":"Cohen","year":"2013"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"CD004366","DOI":"10.1002\/14651858.CD004366.pub6","article-title":"Exercise for depression: some benefits but better trials are needed","volume":"2013","author":"Cooney","year":"2013","journal-title":"Saudi Med. J."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"2432","DOI":"10.1001\/jama.2014.4930","article-title":"Exercise for depression","volume":"311","author":"Cooney","year":"2014","journal-title":"J. Am. Med. Assoc."},{"key":"ref22","doi-asserted-by":"publisher","first-page":"152060","DOI":"10.1016\/J.SEMARTHRIT.2022.152060","article-title":"The economic burden of fibromyalgia: A systematic literature review","volume":"56","author":"D\u2019Onghia","year":"2022","journal-title":"Semin. Arthritis Rheum."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.3389\/fphys.2018.01097","article-title":"Prescribed versus preferred intensity resistance exercise in fibromyalgia pain","volume":"9","author":"da Cunha Ribeiro","year":"2018","journal-title":"Front. Physiol."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"175","DOI":"10.3758\/BF03193146","article-title":"G*power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences","volume":"39","author":"Faul","year":"2007","journal-title":"Behav. Res. Methods"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"e90767","DOI":"10.1371\/journal.pone.0090767","article-title":"Strengthening exercises improve symptoms and quality of life but do not change autonomic modulation in fibromyalgia: A randomized clinical trial","volume":"9","author":"Gavi","year":"2014","journal-title":"PLoS One"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/S0140-6736(24)00909-7","article-title":"Effect of a self-guided digital behavioral therapy for fibromyalgia: a phase III, multicenter randomized controlled trial (PROSPER-FM)","volume":"404","author":"Gendreau","year":"2024","journal-title":"Lancet"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-244X-14-187","article-title":"Pain, not chronic disease, is associated with the recurrence of depressive and anxiety disorders","volume":"14","author":"Gerrits","year":"2014","journal-title":"BMC Psychiatry"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1001\/JAMAPSYCHIATRY.2018.0572","article-title":"Association of Efficacy of resistance exercise training with depressive symptoms: Meta-analysis and Meta-regression analysis of randomized clinical trials","volume":"75","author":"Gordon","year":"2018","journal-title":"JAMA Psychiatry"},{"key":"ref29","first-page":"453","article-title":"Validation of a Portuguese version of the Beck depression inventory and state-trait anxiety inventory in Brazilian subjects","volume":"29","author":"Gorenstein","year":"1996","journal-title":"Braz. J. Med. Biol. Res."},{"key":"ref30","first-page":"245","article-title":"Invent\u00e1rio de depress\u00e3o de Beck: propriedades psicom\u00e9tricas da vers\u00e3o em portugu\u00eas","volume":"25","author":"Gorenstein","year":"1998","journal-title":"Rev. Psiquiatr. Cl\u00edn."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1136\/ard.60.1.21","article-title":"Strength training induced adaptations in neuromuscular function of premenopausal women with fibromyalgia: comparison with healthy women","volume":"60","author":"H\u00e4kkinen","year":"2001","journal-title":"Ann. Rheum. Dis."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"953","DOI":"10.2165\/00007256-200131140-00001","article-title":"Prescription of resistance training for healthy populations","volume":"31","author":"Hass","year":"2001","journal-title":"Sports Med."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1007\/978-3-319-59963-2_11","article-title":"Fibromyalgia","volume":"1","author":"H\u00e4user","year":"2015","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.ejpain.2009.01.006","article-title":"Guidelines on the management of fibromyalgia syndrome - A systematic review","volume":"14","author":"H\u00e4user","year":"2010","journal-title":"Eur. J. Pain"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1249\/01.MSS.0000121945.36635.61","article-title":"Fundamentals of resistance training: progression and exercise prescription","volume":"36","author":"Kraemer","year":"2004","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref36","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1186\/s12891-016-1027-6","article-title":"Fibromyalgia-related costs and loss of productivity: a substantial societal burden","volume":"17","author":"Lacasse","year":"2016","journal-title":"BMC Musculoskelet. Disord."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1136\/annrheumdis-2016-209724","article-title":"EULAR revised recommendations for the management of fibromyalgia","volume":"76","author":"Macfarlane","year":"2017","journal-title":"Ann. Rheum. Dis."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"1482","DOI":"10.1080\/09638288.2016.1202335","article-title":"The relation of social support and depression in patients with chronic low back pain","volume":"39","author":"McKillop","year":"2017","journal-title":"Disabil. Rehabil."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1192\/bjp.bp.114.150516","article-title":"Physical exercise for late-life major depression","volume":"207","author":"Murri","year":"2015","journal-title":"Br. J. Psychiatry"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/J.SEMARTHRIT.2017.04.003","article-title":"Exercise and physical activity in systemic lupus erythematosus: A systematic review with meta-analyses","volume":"47","author":"O\u2019Dwyer","year":"2017","journal-title":"Semin. Arthritis Rheum."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.jpsychires.2016.02.023","article-title":"Exercise as a treatment for depression: A meta-analysis adjusting for publication bias","volume":"77","author":"Schuch","year":"2016","journal-title":"J. Psychiatr. Res."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1136\/bmj.c332","article-title":"CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials","volume":"340","author":"Schulz","year":"2010","journal-title":"BMJ (Online)"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.ctim.2019.07.006","article-title":"Effect of yoga on the quality of life of patients with rheumatic diseases: systematic review with meta-analysis","volume":"46","author":"Sieczkowska","year":"2019","journal-title":"Complement. Ther. 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Gerontol. Ser. A"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.jsams.2013.03.010","article-title":"Exercise and the treatment of depression: A review of the exercise program variables","volume":"17","author":"Stanton","year":"2014","journal-title":"J. Sci. Med. 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Rheumatol."},{"key":"ref51","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/S11845-022-03205-5","article-title":"Effects of resistance training on the physical symptoms and functional capacity of patients with fibromyalgia: a systematic review and meta-analysis of randomized clinical trials","volume":"192","author":"Vilarino","year":"","journal-title":"Ir. J. Med. Sci."},{"key":"ref52","doi-asserted-by":"publisher","first-page":"122","DOI":"10.4081\/reumatismo.2022.1452","article-title":"Can different degrees of resistance training improve mood states in patients with fibromyalgia? 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