{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:25:39Z","timestamp":1753892739617,"version":"3.41.2"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T00:00:00Z","timestamp":1733875200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Psychol."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the prevalence of depression, anxiety, insomnia, and somatic symptom disorder (SSD) in patients with benign and malignant sinonasal tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Pretreatment patients with sinonasal tumors were prospectively recruited on the rhinology ward of a tertiary hospital from July 2021 to March 2022. The electronic questionnaire which contains the rhinological symptom scale, the 22-item Sinonasal Outcome Test (SNOT-22) Scale, the Patient Health Questionnaire-9 (PHQ-9), the Generalized Anxiety Disorder-7 (GAD-7), the Insomnia Severity Index (ISI), and the Patient Health Questionnaire-15 (PHQ-15) was filled out by patients at admission. The associations between the scores of symptom\/SNOT-22 and psychometric tests were assessed by the Pearson correlation coefficient (<jats:italic>r<\/jats:italic>) and simple linear regression. The receiver operating characteristic (ROC) analysis was used to evaluate the performance of the SNOT-22 score in predicting psychiatric disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirteen patients with benign sinonasal tumors and 15 patients with malignant sinonasal tumors were recruited. The benign and malignant groups did not differ significantly regarding symptomatology and mental wellbeing. Of the total patients, 9 were at risk of depression (PHQ-9\u202f&amp;gt;\u202f4), 10 were at risk of anxiety (GAD-7\u202f&amp;gt;\u202f4), 11 were at risk of insomnia (ISI\u202f&amp;gt;\u202f7), and 11 were at risk of SSD (PHQ-15\u202f&amp;gt;\u202f4). The overall symptom, facial pain\/pressure, postnasal drip, and SNOT-22 scores were positively associated with scores of psychometric tests. Patients with a high SNOT-22 score (&amp;gt;18) are likely to be affected by comorbid psychiatric disorders. When interpreting the results of this study, it should be noted that screening tools, not diagnostic tools, were used to identify psychiatric risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Depression, anxiety, insomnia, and SSD are prevalent in patients with sinonasal tumors. Otolaryngologists should have a low threshold to ask the patient about psychiatric symptoms, especially for patients with an SNOT-22 score\u202f&amp;gt;\u202f18.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fpsyg.2024.1444522","type":"journal-article","created":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T04:47:58Z","timestamp":1733892478000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Psychiatric disorders in patients with benign and malignant sinonasal tumors: a prospective cross-sectional study"],"prefix":"10.3389","volume":"15","author":[{"given":"Guang-Ye","family":"Zhan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-Fang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong-Fang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Hui","family":"Wen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Ping","family":"Wen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,12,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"3921","DOI":"10.1007\/s00520-019-05244-8","article-title":"Hospital anxiety and depression scale (HADS) accuracy in cancer patients","volume":"28","author":"Annunziata","year":"2020","journal-title":"Support Care Cancer"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/s1389-9457(00)00065-4","article-title":"Validation of the insomnia severity index as an outcome measure for insomnia research","volume":"2","author":"Bastien","year":"2001","journal-title":"Sleep Med."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1002\/alr.22398","article-title":"Sinonasal quality-of-life outcomes after endoscopic endonasal skull base surgery","volume":"9","author":"Bhenswala","year":"2019","journal-title":"Int. Forum Allergy Rhinol."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1097\/moo.0000000000000774","article-title":"Quality of life in sinonasal tumors: an up-to-date review","volume":"30","author":"Chow","year":"2022","journal-title":"Curr. Opin. Otolaryngol. Head Neck Surg."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"151","DOI":"10.2500\/ajra.2015.29.4137","article-title":"Comparative analysis of quality-of-life metrics after endoscopic surgery for sinonasal neoplasms","volume":"29","author":"Deckard","year":"2015","journal-title":"Am. J. Rhinol. Allergy"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1001\/jama.249.6.751","article-title":"The prevalence of psychiatric disorders among cancer patients","volume":"249","author":"Derogatis","year":"1983","journal-title":"JAMA"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"137","DOI":"10.4103\/2229-3485.86879","article-title":"Patient-reported outcomes: a new era in clinical research","volume":"2","author":"Deshpande","year":"2011","journal-title":"Perspect. Clin. Res."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1002\/alr.23261","article-title":"Predictive factors for decreased baseline quality of life in patients with sinonasal malignancies","volume":"14","author":"Fleseriu","year":"2023","journal-title":"Int. Forum Allergy Rhinol."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1002\/lary.26833","article-title":"Sinonasal quality of life after endoscopic resection of malignant sinonasal and skull base tumors","volume":"128","author":"Glicksman","year":"2018","journal-title":"Laryngoscope"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/j.trecan.2024.05.008","article-title":"Reconceptualizing mental health in cancer survivorship","volume":"10","author":"Haywood","year":"2024","journal-title":"Trends Cancer"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"107","DOI":"10.4172\/2161-119x.1000107","article-title":"Psychological manifestation of patients with Sinonasal tumors: An Obsc ured and commonly neglected aspect of the disease","volume":"1","author":"James Fasunla","year":"2011","journal-title":"Otolaryngology"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1186\/1471-244x-13-91","article-title":"Standardization of a screening instrument (PHQ-15) for somatization syndromes in the general population","volume":"13","author":"Kocalevent","year":"2013","journal-title":"BMC Psychiatry"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1186\/s12888-020-02953-x","article-title":"Sense of coherence, mental well-being and perceived preoperative hospital and surgery related stress in surgical patients with malignant, benign, and no neoplasms","volume":"20","author":"Krampe","year":"2020","journal-title":"BMC Psychiatry"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1046\/j.1525-1497.2001.016009606.x","article-title":"The PHQ-9: validity of a brief depression severity measure","volume":"16","author":"Kroenke","year":"2001","journal-title":"J. Gen. Intern. Med."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1097\/00006842-200203000-00008","article-title":"The PHQ-15: validity of a new measure for evaluating the severity of somatic symptoms","volume":"64","author":"Kroenke","year":"2002","journal-title":"Psychosom. Med."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1186\/s12916-024-03451-7","article-title":"Association of depressive symptoms and sleep disturbances with survival among US adult cancer survivors","volume":"22","author":"Lan","year":"2024","journal-title":"BMC Med."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1055\/s-0039-1679889","article-title":"Mental health disorders associated with Sinonasal and Skull Base malignancies: a large cohort study","volume":"81","author":"Lee","year":"2020","journal-title":"J. Neurol. Surg. Skull. Base"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"l1476","DOI":"10.1136\/bmj.l1476","article-title":"Accuracy of patient health Questionnaire-9 (PHQ-9) for screening to detect major depression: individual participant data meta-analysis","volume":"365","author":"Levis","year":"2019","journal-title":"BMJ"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1097\/MLR.0b013e318160d093","article-title":"Validation and standardization of the generalized anxiety disorder screener (GAD-7) in the general population","volume":"46","author":"L\u00f6we","year":"2008","journal-title":"Med. Care"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1200\/jco.23.01465","article-title":"Psychological outcomes in adolescent and young adult Cancer survivors","volume":"42","author":"McGrady","year":"2024","journal-title":"J. Clin. Oncol."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1093\/sleep\/34.5.601","article-title":"The insomnia severity index: psychometric indicators to detect insomnia cases and evaluate treatment response","volume":"34","author":"Morin","year":"2011","journal-title":"Sleep"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.coms.2023.03.002","article-title":"Malignant and Nonmalignant Sinonasal Tumors","volume":"35","author":"Nagornaya","year":"2023","journal-title":"Oral Maxillofac. Surg. Clin. North Am."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1200\/jco.23.01615","article-title":"Mental disorders among adolescents and young adults with Cancer: a Canadian population-based and sibling cohort study","volume":"42","author":"Oberoi","year":"2024","journal-title":"J. Clin. Oncol."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1053\/smrv.2002.0186","article-title":"Epidemiology of insomnia: what we know and what we still need to learn","volume":"6","author":"Ohayon","year":"2002","journal-title":"Sleep Med. Rev."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"E2212-e 2221","DOI":"10.1002\/lary.29339","article-title":"Quality of life outcomes in patients with Sinonasal malignancy after definitive treatment","volume":"131","author":"Philips","year":"2021","journal-title":"Laryngoscope"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1002\/alr.22486","article-title":"Incidence, risk factors, and outcomes of endoscopic sinus surgery after endoscopic skull-base surgery","volume":"10","author":"Shah","year":"2020","journal-title":"Int. Forum Allergy Rhinol."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1186\/s12888-020-02613-0","article-title":"Normative data and psychometric properties of the patient health Questionnaire-9 in a nationally representative Korean population","volume":"20","author":"Shin","year":"2020","journal-title":"BMC Psychiatry"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1001\/archinte.166.10.1092","article-title":"A brief measure for assessing generalized anxiety disorder: the GAD-7","volume":"166","author":"Spitzer","year":"2006","journal-title":"Arch. Intern. Med."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"1309702","DOI":"10.3389\/fpsyt.2024.1309702","article-title":"Incidence and risk factors for psychological distress in adult female patients with breast cancer: a systematic review and meta-analysis","volume":"15","author":"Tao","year":"2024","journal-title":"Front. Psych."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1370\/afm.985","article-title":"Detecting somatoform disorders in primary care with the PHQ-15","volume":"7","author":"van Ravesteijn","year":"2009","journal-title":"Ann. Fam. Med."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"1408762","DOI":"10.3389\/fpsyt.2024.1408762","article-title":"Research progress on the psychological burden and intervention measures in cancer patients","volume":"15","author":"Wang","year":"2024","journal-title":"Front. Psych."}],"container-title":["Frontiers in Psychology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpsyg.2024.1444522\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T04:48:01Z","timestamp":1733892481000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpsyg.2024.1444522\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,11]]},"references-count":31,"alternative-id":["10.3389\/fpsyg.2024.1444522"],"URL":"https:\/\/doi.org\/10.3389\/fpsyg.2024.1444522","relation":{},"ISSN":["1664-1078"],"issn-type":[{"type":"electronic","value":"1664-1078"}],"subject":[],"published":{"date-parts":[[2024,12,11]]},"article-number":"1444522"}}